The mitochondrial permeability transition pore: an evolving concept critical for cell life and death

Intranasal insulin improves mitochondrial function and attenuates motor deficits in a rat 6‐OHDA model of Parkinson's disease

(2021) Farideh Iravanpour et al.   CNS Neuroscience & Therapeutics

Targeting the mitochondrial permeability transition pore for neuroprotection in a piglet model of neonatal hypoxic‐ischemic encephalopathy

(2021) May W. Chen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Role of Mitochondrial Calcium and the Permeability Transition Pore in Regulating Cell Death

(2020) Tyler M. Bauer et al.   CIRCULATION RESEARCH

Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D

(2020) Runa S.J. Lindblom et al.   CLINICAL SCIENCE

Melatonin Inhibits Formation of Mitochondrial Permeability Transition Pores and Improves Oxidative Phosphorylation of Frozen-Thawed Ram Sperm

(2020) Yi Fang et al.   Frontiers in Endocrinology

Mitochondrial Calcium Regulation of Redox Signaling in Cancer

(2020) Céline Delierneux et al.   Cells

Mitochondrial permeability transition pore is involved in oxidative burst and NETosis of human neutrophils

(2020) Nina Vorobjeva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy

(2020) Kendall B. Wallace et al.   CIRCULATION RESEARCH

Double agents of cell death: novel emerging functions of apoptotic regulators

(2020) Heather M. Lamb   FEBS Journal

Membrane current evoked by mitochondrial Na+–Ca2+ exchange in mouse heart

(2020) Mohammed M. Islam et al.   Journal of Physiological Sciences

Mitochondrial MPTP: A Novel Target of Ethnomedicine for Stroke Treatment by Apoptosis Inhibition

(2020) Yangxin Li et al.   Frontiers in Pharmacology

Targeting the Multiple Physiologic Roles of VDAC With Steroids and Hydrophobic Drugs

(2020) Tatiana K. Rostovtseva et al.   Frontiers in Physiology

Mitochondrial Ca2+ regulation in the etiology of heart failure: physiological and pathophysiological implications

(2020) Hai-xia Xu et al.   ACTA PHARMACOLOGICA SINICA

Maintaining social contacts: The physiological relevance of organelle interactions

(2020) Beatriz S.C. Silva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial ion channels as targets for cardioprotection

(2020) Derek J. Hausenloy et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Melatonin improves cryopreservation of ram sperm by inhibiting mitochondrial permeability transition pore opening

(2020) Yi Fang et al.   REPRODUCTION IN DOMESTIC ANIMALS

Cyclophilin D binds to the acidic C-terminus region of α-Synuclein and affects its aggregation characteristics

(2020) James Torpey et al.   Scientific Reports

Structural insights into the Ca2+-dependent gating of the human mitochondrial calcium uniporter

(2020) Yan Wang et al.   eLife

The very low number of calcium-induced permeability transition pores in the single mitochondrion

(2020) Maria A. Neginskaya et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure and Reconstitution of an MCU–EMRE Mitochondrial Ca2+ Uniporter Complex

(2020) Chongyuan Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca2+uptake

(2020) Horia Vais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion

(2020) Stephen Hurst et al.   Cell Death & Disease

The Unique Cysteine of F-ATP Synthase OSCP Subunit Participates in Modulation of the Permeability Transition Pore

(2020) Michela Carraro et al.   Cell Reports

A phenyl pyrrolidine derivative reveals a dual inhibition mechanism of myocardial mitochondrial permeability transition pore, which is limited by its myocardial distribution.

(2020) mathieu panel et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Electrophysiological properties of the mitochondrial permeability transition pores: Channel diversity and disease implication

(2020) M.A. Neginskaya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore

(2019) Maria A. Neginskaya et al.   Cell Reports

Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

(2019) Ben Zhou et al.   CELL

Progress in understanding mitochondrial calcium uniporter complex‐mediated calcium signalling: A potential target for cancer treatment

(2019) Chaochu Cui et al.   BRITISH JOURNAL OF PHARMACOLOGY

LETM1: Essential for Mitochondrial Biology and Cation Homeostasis?

(2019) Shane Austin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care

(2019) Anna Tarocco et al.   Cell Death & Disease

Grape seed proanthocyanidins ameliorate neuronal oxidative damage by inhibiting GSK-3β-dependent mitochondrial permeability transition pore opening in an experimental model of sporadic Alzheimer’s disease

(2019) Qinru Sun et al.   Aging-US

Mitochondrial Ca2+ Transport: Mechanisms, Molecular Structures, and Role in Cells

(2019) K. N. Belosludtsev et al.   BIOCHEMISTRY-MOSCOW

Small-molecule inhibitors of cyclophilins block opening of the mitochondrial permeability transition pore and protect mice from hepatic ischemia–reperfusion injury

(2019) Mathieu Panel et al.   GASTROENTEROLOGY

Persistence of the permeability transition pore in human mitochondria devoid of an assembled ATP synthase

(2019) Joe Carroll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired NF-κB signalling underlies cyclophilin D-mediated mitochondrial permeability transition pore opening in doxorubicin cardiomyopathy

(2019) Rimpy Dhingra et al.   CARDIOVASCULAR RESEARCH

Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease

(2019) Dominic P. Del Re et al.   PHYSIOLOGICAL REVIEWS

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD

(2019) Jason Karch et al.   Science Advances

ER-Mitochondria Communication in Cells of the Innate Immune System

(2019) Dmitry Namgaladze et al.   Cells

Purified F-ATP synthase forms a Ca2+-dependent high-conductance channel matching the mitochondrial permeability transition pore

(2019) Andrea Urbani et al.   Nature Communications

A mitochondrial megachannel resides in monomeric F1FO ATP synthase

(2019) Nelli Mnatsakanyan et al.   Nature Communications

From the Ca 2+ -activated F 1 F O -ATPase to the mitochondrial permeability transition pore: an overview

(2018) Salvatore Nesci et al.   BIOCHIMIE

Mitochondrial Outer Membrane Channels: Emerging Diversity in Transport Processes

(2018) Thomas Becker et al.   BIOESSAYS

Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia–reperfusion

(2018) Hannah J Whittington et al.   CARDIOVASCULAR RESEARCH

Calcium Signaling and Reactive Oxygen Species in Mitochondria

(2018) Edoardo Bertero et al.   CIRCULATION RESEARCH

Building ER-PM contacts: keeping calm and ready on alarm

(2018) Christopher J Stefan   CURRENT OPINION IN CELL BIOLOGY

Cyclophilin D deficiency attenuates mitochondrial perturbation and ameliorates hepatic steatosis

(2018) Xiaolei Wang et al.   HEPATOLOGY

Discovery of a new mitochondria permeability transition pore (mPTP) inhibitor based on gallic acid

(2018) José Teixeira et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Glycogen synthase kinase-3β opens mitochondrial permeability transition pore through mitochondrial hexokinase II dissociation

(2018) Takamitsu Tanaka et al.   Journal of Physiological Sciences

Inhibitory effect of melatonin on necroptosis via repressing the Ripk3-PGAM5-CypD-mPTP pathway attenuates cardiac microvascular ischemia-reperfusion injury

(2018) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

Melatonin Balance the Autophagy and Apoptosis by Regulating UCP2 in the LPS-Induced Cardiomyopathy

(2018) Pan Pan et al.   MOLECULES

Mitochondrial calcium imbalance in Parkinson’s disease

(2018) Marthe H.R. Ludtmann et al.   NEUROSCIENCE LETTERS

Mitochondrial calcium uptake in organ physiology: from molecular mechanism to animal models

(2018) Cristina Mammucari et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Calcium Dynamics as a Machine for Decoding Signals

(2018) Carlotta Giorgi et al.   TRENDS IN CELL BIOLOGY

The role of endoplasmic reticulum-mitochondria contact sites in the control of glucose homeostasis: an update

(2018) Jennifer Rieusset   Cell Death & Disease

VDAC1 as Pharmacological Target in Cancer and Neurodegeneration: Focus on Its Role in Apoptosis

(2018) Andrea Magrì et al.   Frontiers in Chemistry

Mitochondrial calcium transport and the redox nature of the calcium-induced membrane permeability transition

(2018) Anibal E. Vercesi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discovery of Novel 1,3,8-Triazaspiro[4.5]decane Derivatives That Target the c Subunit of F1/FO-Adenosine Triphosphate (ATP) Synthase for the Treatment of Reperfusion Damage in Myocardial Infarction

(2018) Giampaolo Morciano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Melatonin Uptake by Cells: An Answer to Its Relationship with Glucose?

(2018) Juan C. Mayo et al.   MOLECULES

The machineries, regulation and cellular functions of mitochondrial calcium

(2018) Carlotta Giorgi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease

(2018) María José Pérez et al.   Redox Biology

Toxicity of lupane derivatives on anionic membrane models, isolated rat mitochondria and selected human cell lines: Role of terminal alkyl chains

(2018) Filipa S. Carvalho et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Akt‐mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth

(2018) Saverio Marchi et al.   EMBO JOURNAL

Calcium signalling: A common target in neurological disorders and neurogenesis

(2018) Talita Glaser et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mitochondrial Permeability Transition: A Molecular Lesion with Multiple Drug Targets

(2018) Thomas Briston et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mitochondrial Ca2+ dynamics in cells and suspensions

(2017) Benjamin Wacquier et al.   FEBS Journal

Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: An implication of the therapeutic potential

(2017) Xiaokui Huo et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis

(2017) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

Rotenone decreases ischemia-induced injury by inhibiting mitochondrial permeability transition in mature brains

(2017) Evelina Rekuviene et al.   NEUROSCIENCE LETTERS

Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase

(2017) Jiuya He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase

(2017) Jiuya He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress

(2017) En Huang et al.   Nature Communications

Functional Mitochondria in Health and Disease

(2017) Patries M. Herst et al.   Frontiers in Endocrinology

Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability

(2017) Thomas Briston et al.   Scientific Reports

Quantification of active mitochondrial permeability transition pores using GNX-4975 inhibitor titrations provides insights into molecular identity

(2016) A. P. Richardson et al.   BIOCHEMICAL JOURNAL

The mitochondrial permeability transition pore in AD 2016: An update

(2016) Lucia Biasutto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics

(2016) Dun-Xian Tan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial Ca2+ uptake pathways

(2016) Pia A. Elustondo et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mitochondrial Ca2+ and regulation of the permeability transition pore

(2016) Stephen Hurst et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Physiological roles of the mitochondrial permeability transition pore

(2016) Nelli Mnatsakanyan et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The rise of mitochondria in medicine

(2016) Martin Picard et al.   MITOCHONDRION

Melatonin modulates permeability transition pore and 5-hydroxydecanoate induced KATP channel inhibition in isolated brain mitochondria

(2016) Mohammad Waseem et al.   MITOCHONDRION

Comprehensive analysis of mitochondrial permeability transition pore activity in living cells using fluorescence-imaging-based techniques

(2016) Massimo Bonora et al.   Nature Protocols

Mitochondrial Permeability Transition: New Findings and Persisting Uncertainties

(2016) Valentina Izzo et al.   TRENDS IN CELL BIOLOGY

Identification of a Small Molecule Cyclophilin D Inhibitor for Rescuing Aβ-Mediated Mitochondrial Dysfunction

(2016) Koteswara Rao Valasani et al.   ACS Medicinal Chemistry Letters

MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics

(2016) Dhanendra Tomar et al.   Cell Reports

Nanoparticle-Mediated Targeting of Cyclosporine A Enhances Cardioprotection Against Ischemia-Reperfusion Injury Through Inhibition of Mitochondrial Permeability Transition Pore Opening

(2016) Gentaro Ikeda et al.   Scientific Reports

Calcineurin inhibitors cyclosporine A and tacrolimus induce vascular inflammation and endothelial activation through TLR4 signaling

(2016) Raquel Rodrigues-Diez et al.   Scientific Reports

Calcium signaling as a mediator of cell energy demand and a trigger to cell death

(2015) Gauri Bhosale et al.   Annals of the New York Academy of Sciences

Knockout of cyclophilin D in Ppif−/− mice increases stability of brain mitochondria against Ca2+ stress

(2015) T. Gainutdinov et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

(2015) Sudeshna Roy et al.   ChemMedChem

N-Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

(2015) Sudeshna Roy et al.   ChemMedChem

CypD: The Key to the Death Door

(2015) Shaik Fayaz et al.   CNS & Neurological Disorders-Drug Targets

The mitochondrial permeability transition pore and its role in myocardial ischemia reperfusion injury

(2015) Sang-Bing Ong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury

(2015) Giampaolo Morciano et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitoflash altered by metabolic stress in insulin-resistant skeletal muscle

(2015) Yi Ding et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mitochondrial ATP-Mg/Pi Carrier SCaMC-3/Slc25a23 Counteracts PARP-1-Dependent Fall in Mitochondrial ATP Caused by Excitotoxic Insults in Neurons

(2015) C. B. Rueda et al.   JOURNAL OF NEUROSCIENCE

Daily differential expression of melatonin-related genes and clock genes in rat cumulus-oocyte complex: changes after pinealectomy

(2015) L. A. Coelho et al.   JOURNAL OF PINEAL RESEARCH

Enhanced oxidative stress sensitizes the mitochondrial permeability transition pore to opening in heart from Zucker Fa/fa rats with type 2 diabetes

(2015) Adriana Riojas-Hernández et al.   LIFE SCIENCES

Cyclosporine before PCI in Patients with Acute Myocardial Infarction

(2015) Thien-Tri Cung et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

(2015) Paolo Bernardi et al.   PHYSIOLOGICAL REVIEWS

New functions of mitochondria associated membranes in cellular signaling

(2014) Alexander R. van Vliet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Voltage-dependent anion channels: the wizard of the mitochondrial outer membrane

(2014) Barbara Mertins et al.   BIOLOGICAL CHEMISTRY

HIF-1 reduces ischaemia–reperfusion injury in the heart by targeting the mitochondrial permeability transition pore

(2014) Sang-Ging Ong et al.   CARDIOVASCULAR RESEARCH

The mitochondrial permeability transition pore is a dispensable element for mitochondrial calcium efflux

(2014) Elena De Marchi et al.   CELL CALCIUM

Mitochondrial metabolism directs stemness and differentiation in P19 embryonal carcinoma stem cells

(2014) I Vega-Naredo et al.   CELL DEATH AND DIFFERENTIATION

Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy

(2014) J Q Kwong et al.   CELL DEATH AND DIFFERENTIATION

Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake

(2014) L. Wang et al.   EMBO JOURNAL

Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results

(2014) D. Atar et al.   EUROPEAN HEART JOURNAL

NCLX Protein, but Not LETM1, Mediates Mitochondrial Ca2+Extrusion, Thereby Limiting Ca2+-induced NAD(P)H Production and Modulating Matrix Redox State

(2014) Umberto De Marchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

F-ATPase ofDrosophila melanogasterForms 53-Picosiemen (53-pS) Channels Responsible for Mitochondrial Ca2+-induced Ca2+Release

(2014) Sophia von Stockum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the Mitochondrial Permeability Transition Pore by the Outer Membrane Does Not Involve the Peripheral Benzodiazepine Receptor (Translocator Protein of 18 kDa (TSPO))

(2014) Justina Šileikytė et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Channel Formation by Yeast F-ATP Synthase and the Role of Dimerization in the Mitochondrial Permeability Transition

(2014) Michela Carraro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure Based Design, Synthesis, Pharmacophore Modeling, Virtual Screening, and Molecular Docking Studies for Identification of Novel Cyclophilin D Inhibitors

(2014) Koteswara Rao Valasani et al.   Journal of Chemical Information and Modeling

Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition

(2014) Manuel Gutiérrez-Aguilar et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The destiny of Ca2+ released by mitochondria

(2014) Ayako Takeuchi et al.   Journal of Physiological Sciences

SLC25A23 augments mitochondrial Ca2+ uptake, interacts with MCU, and induces oxidative stress–mediated cell death

(2014) Nicholas E. Hoffman et al.   MOLECULAR BIOLOGY OF THE CELL

MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity

(2014) Maria Patron et al.   MOLECULAR CELL

Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans

(2014) En-Zhi Shen et al.   NATURE

Molecular and functional identification of a mitochondrial ryanodine receptor in neurons

(2014) Regina Jakob et al.   NEUROSCIENCE LETTERS

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

(2014) K. N. Alavian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GNX-4728, a novel small molecule drug inhibitor of mitochondrial permeability transition, is therapeutic in a mouse model of amyotrophic lateral sclerosis

(2014) Lee J. Martin et al.   Frontiers in Cellular Neuroscience

LETM1 in mitochondrial cation transport

(2014) Karin Nowikovsky et al.   Frontiers in Physiology

Dimethylaminopyridine derivatives of lupane triterpenoids cause mitochondrial disruption and induce the permeability transition

(2013) Telma C. Bernardo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Potential role of subunit c of F0F1-ATPase and subunit c of storage body in the mitochondrial permeability transition. Effect of the phosphorylation status of subunit c on pore opening

(2013) Tamara Azarashvili et al.   CELL CALCIUM

Role of the c subunit of the FOATP synthase in mitochondrial permeability transition

(2013) Massimo Bonora et al.   CELL CYCLE

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

Physiologic Functions of Cyclophilin D and the Mitochondrial Permeability Transition Pore

(2013) John W. Elrod et al.   CIRCULATION JOURNAL

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

(2013) Anna Raffaello et al.   EMBO JOURNAL

Functional reconstitution of the mitochondrial Ca2+/H+antiporter Letm1

(2013) Ming-Feng Tsai et al.   JOURNAL OF GENERAL PHYSIOLOGY

Permeability transition pore-mediated mitochondrial superoxide flashes mediate an early inhibitory effect of amyloid beta1−42 on neural progenitor cell proliferation

(2013) Yan Hou et al.   NEUROBIOLOGY OF AGING

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

(2013) Molly Plovanich et al.   PLoS One

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-dependent dissociation of ATP synthase dimers and loss of inner-membrane cristae in mitochondria

(2013) B. Daum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

(2013) Y. Sancak et al.   SCIENCE

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

(2013) Jason Karch et al.   eLife

Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle

(2013) E.P. Taddeo et al.   Molecular Metabolism

Inhibition of complex I regulates the mitochondrial permeability transition through a phosphate-sensitive inhibitory site masked by cyclophilin D

(2012) Bo Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The permeability transition pore as a Ca2+ release channel: New answers to an old question

(2012) Paolo Bernardi et al.   CELL CALCIUM

Redox Signaling in Cardiac Physiology and Pathology

(2012) Joseph R. Burgoyne et al.   CIRCULATION RESEARCH

Physiological Roles of the Permeability Transition Pore

(2012) Catherine Brenner et al.   CIRCULATION RESEARCH

Mitochondria in Control of Cell Fate

(2012) Clifford D.L. Folmes et al.   CIRCULATION RESEARCH

Mitochondrial VDAC1: Function in Cell Life and Death and a Target for Cancer Therapy

(2012) V. Shoshan-Barmatz et al.   CURRENT MEDICINAL CHEMISTRY

Cardioprotective effect of Danshensu against myocardial ischemia/reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation

(2012) Ying Yin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Mitochondrial Permeability Transition Pore Inhibitor Improves Renal Outcomes After Revascularization in Experimental Atherosclerotic Renal Artery Stenosis

(2012) Alfonso Eirin et al.   HYPERTENSION

Molecular Identity and Functional Properties of the Mitochondrial Na+/Ca2+Exchanger

(2012) Raz Palty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Pathophysiology of LETM1

(2012) Karin Nowikovsky et al.   JOURNAL OF GENERAL PHYSIOLOGY

Molecular identities of mitochondrial Ca2+influx mechanism: Updated passwords for accessing mitochondrial Ca2+-linked health and disease

(2012) Jin O-Uchi et al.   JOURNAL OF GENERAL PHYSIOLOGY

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

(2012) Karthik Mallilankaraman et al.   NATURE CELL BIOLOGY

Endoplasmic reticulum–mitochondria contacts: function of the junction

(2012) Ashley A. Rowland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Superoxide Production Negatively Regulates Neural Progenitor Proliferation and Cerebral Cortical Development

(2012) Yan Hou et al.   STEM CELLS

Regulation of mitochondrial function by voltage dependent anion channels in ethanol metabolism and the Warburg effect

(2011) John J. Lemasters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

VDAC, The early days

(2011) Marco Colombini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Drug-induced Cardiac Mitochondrial Toxicity and Protection: From Doxorubicin to Carvedilol

(2011) Goncalo C. Pereira et al.   CURRENT PHARMACEUTICAL DESIGN

The Permeability Transition Pore Controls Cardiac Mitochondrial Maturation and Myocyte Differentiation

(2011) Jennifer R. Hom et al.   DEVELOPMENTAL CELL

Oxidative stress, mitochondrial permeability transition pore opening and cell death during hypoxia–reoxygenation in adult cardiomyocytes

(2011) Rana Assaly et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Uncoupling proteins and the control of mitochondrial reactive oxygen species production

(2011) Ryan J. Mailloux et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective Role of Transient Pore Openings in Calcium Handling by Cardiac Mitochondria

(2011) Paavo Korge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin preserves the transient mitochondrial permeability transition for protection during mitochondrial Ca2+ stress in astrocyte

(2011) Mei-Jie Jou   JOURNAL OF PINEAL RESEARCH

The roles of phosphate and the phosphate carrier in the mitochondrial permeability transition pore

(2011) Pinadda Varanyuwatana et al.   MITOCHONDRION

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Characterization of human VDAC isoforms: A peculiar function for VDAC3?

(2010) Vito De Pinto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial cyclophilin-D as a critical mediator of ischaemic preconditioning

(2010) D. J. Hausenloy et al.   CARDIOVASCULAR RESEARCH

Inhibition of mitochondrial permeability transition to prevent the post-cardiac arrest syndrome: a pre-clinical study

(2010) M. Cour et al.   EUROPEAN HEART JOURNAL

Evaluation of cyclosporine A in a stroke model in the immature rat brain

(2010) Pierre-Louis Leger et al.   EXPERIMENTAL NEUROLOGY

Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels

(2010) Shin-Young Ryu et al.   FEBS LETTERS

Cyclophilin D controls mitochondrial pore–dependent Ca2+ exchange, metabolic flexibility, and propensity for heart failure in mice

(2010) John W. Elrod et al.   JOURNAL OF CLINICAL INVESTIGATION

Melatonin Reduces Apoptosis Induced by Calcium Signaling in Human Leukocytes: Evidence for the Involvement of Mitochondria and Bax Activation

(2010) Javier Espino et al.   JOURNAL OF MEMBRANE BIOLOGY

TRO40303, a New Cardioprotective Compound, Inhibits Mitochondrial Permeability Transition

(2010) S. Schaller et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Endurance training reverts heart mitochondrial dysfunction, permeability transition and apoptotic signaling in long-term severe hyperglycemia

(2010) José Lumini-Oliveira et al.   MITOCHONDRION

Doxorubicin induces mitochondrial permeability transition and contractile dysfunction in the human myocardium

(2010) David Montaigne et al.   MITOCHONDRION

Ca2+ Hot Spots on the Mitochondrial Surface Are Generated by Ca2+ Mobilization from Stores, but Not by Activation of Store-Operated Ca2+ Channels

(2010) Marta Giacomello et al.   MOLECULAR CELL

Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases

(2010) Tara L. Davis et al.   PLOS BIOLOGY

Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening

(2009) Giuseppe Petrosillo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation

(2009) Sylvanie Malouitre et al.   BIOCHEMICAL JOURNAL

Inhibition of mitochondrial permeability transition pore opening: translation to patients

(2009) L. Gomez et al.   CARDIOVASCULAR RESEARCH

Store-operated Ca2+ influx and subplasmalemmal mitochondria

(2009) Marek K. Korzeniowski et al.   CELL CALCIUM

SLP-2 negatively modulates mitochondrial sodium–calcium exchange

(2009) Sandrine Da Cruz et al.   CELL CALCIUM

Effect of Transient and Permanent Permeability Transition Pore Opening on NAD(P)H Localization in Intact Cells

(2009) Jean François Dumas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclophilin D Modulates Mitochondrial F0F1-ATP Synthase by Interacting with the Lateral Stalk of the Complex

(2009) Valentina Giorgio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What is the mitochondrial permeability transition pore?

(2009) Andrew P. Halestrap   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Visualization of melatonin’s multiple mitochondrial levels of protection against mitochondrial Ca2+-mediated permeability transition and beyond in rat brain astrocytes

(2009) Mei-Jie Jou et al.   JOURNAL OF PINEAL RESEARCH

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

(2009) Sonia Gandhi et al.   MOLECULAR CELL

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

(2009) R. Palty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide RNAi Screen Identifies Letm1 as a Mitochondrial Ca2+/H+ Antiporter

(2009) D. Jiang et al.   SCIENCE

Superoxide Flashes in Single Mitochondria

(2008) Wang Wang et al.   CELL

Mitochondrial Ca2+ and the heart

(2008) E DEDKOVA et al.   CELL CALCIUM

The Mitochondrial Phosphate Carrier Interacts with Cyclophilin D and May Play a Key Role in the Permeability Transition

(2008) Anna W. C. Leung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytoplasmic Na+-dependent modulation of mitochondrial Ca2+via electrogenic mitochondrial Na+-Ca2+exchange

(2008) Bongju Kim et al.   JOURNAL OF PHYSIOLOGY-LONDON

Melatonin uptake in prostate cancer cells: intracellular transport versus simple passive diffusion

(2008) David Hevia et al.   JOURNAL OF PINEAL RESEARCH

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction

(2008) Christophe Piot et al.   NEW ENGLAND JOURNAL OF MEDICINE