Discovery of a new mitochondria permeability transition pore (mPTP) inhibitor based on gallic acid

Mitochondrial targeted curcumin exhibits anticancer effects through disruption of mitochondrial redox and modulation of TrxR2 activity

(2017) Sundarraj Jayakumar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Development of a Mitochondriotropic Antioxidant Based on Caffeic Acid: Proof of Concept on Cellular and Mitochondrial Oxidative Stress Models

(2017) José Teixeira et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria

(2017) José Teixeira et al.   Scientific Reports

Computer-aided discovery of biological activity spectra for anti-aging and anti-cancer olive oil oleuropeins

(2016) Bruna Corominas-Faja et al.   Aging-US

Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications

(2015) Nadezda Apostolova et al.   ANTIOXIDANTS & REDOX SIGNALING

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

(2015) D.J.R. Lane et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The mitochondrial permeability transition pore and its role in myocardial ischemia reperfusion injury

(2015) Sang-Bing Ong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

(2015) Paolo Bernardi et al.   PHYSIOLOGICAL REVIEWS

Novel Gallate Triphenylphosphonium Derivatives with Potent Antichagasic Activity

(2015) Leonel A. Cortes et al.   PLoS One

Design, synthesis and biological evaluation of mitochondria targeting theranostic agents

(2014) Song Wu et al.   CHEMICAL COMMUNICATIONS

Mitochondria-targeted Resveratrol Derivatives Act as Cytotoxic Pro-oxidants

(2014) Nicola Sassi et al.   CURRENT PHARMACEUTICAL DESIGN

Antiproliferative and Uncoupling Effects of Delocalized, Lipophilic, Cationic Gallic Acid Derivatives on Cancer Cell Lines. Validation in Vivo in Singenic Mice

(2014) José A. Jara et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial-Targeted Curcuminoids: A Strategy to Enhance Bioavailability and Anticancer Efficacy of Curcumin

(2014) Cheruku Apoorva Reddy et al.   PLoS One

Mitochondrial permeability transition pore is a potential drug target for neurodegeneration

(2013) Valasani Koteswara Rao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Targeting the Mitochondrial Electron Transport Chain Complexes for the Induction of Apoptosis and Cancer Treatment

(2013) Jakub Rohlena et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Targeting mitochondria: Strategies, innovations and challenges

(2013) Marvin Edeas et al.   MITOCHONDRION

Pharmacological approaches to restore mitochondrial function

(2013) Pénélope A. Andreux et al.   NATURE REVIEWS DRUG DISCOVERY

Cytotoxicity of a mitochondriotropic quercetin derivative: Mechanisms

(2012) Nicola Sassi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid scaffold

(2012) JosÉ Teixeira et al.   FREE RADICAL RESEARCH

Antioxidant therapy: Still in search of the ‘magic bullet’

(2012) Sofia Benfeito et al.   MITOCHONDRION

Mitochondrial oxidative stress and the metabolic syndrome

(2012) Andrew M. James et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondrial pharmacology

(2012) Robin A.J. Smith et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Lipophilic Caffeic and Ferulic Acid Derivatives Presenting Cytotoxicity against Human Breast Cancer Cells

(2011) Teresa L. Serafim et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Oxidative stress, mitochondrial permeability transition pore opening and cell death during hypoxia–reoxygenation in adult cardiomyocytes

(2011) Rana Assaly et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Derivatives of Rhodamine 19 as Mild Mitochondria-targeted Cationic Uncouplers

(2011) Yuri N. Antonenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Medicinal Chemistry of ATP Synthase: A Potential Drug Target of Dietary Polyphenols and Amphibian Antimicrobial Peptides

(2010) Zulfiqar Ahmad et al.   CURRENT MEDICINAL CHEMISTRY

Exogenous Antioxidants—Double-Edged Swords in Cellular Redox State: Health Beneficial Effects at Physiologic Doses versus Deleterious Effects at High Doses

(2010) Jaouad Bouayed et al.   Oxidative Medicine and Cellular Longevity

Impact of mitochondriotropic quercetin derivatives on mitochondria

(2009) Lucia Biasutto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding

(2009) Nathan R. Perron et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

A modern approach to the treatment of mitochondrial disease

(2009) Sumit Parikh et al.   Current Treatment Options in Neurology

Gallic acid prevents lysosomal damage in isoproterenol induced cardiotoxicity in Wistar rats

(2009) Ponnian Stanely Mainzen Prince et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Gastroprotective Effect of Ginger Rhizome(Zingiber officinale)Extract: Role of Gallic Acid and Cinnamic Acid in H+, K+-ATPase/H. pyloriInhibition and Anti-Oxidative Mechanism

(2009) Siddaraju M. Nanjundaiah et al.   Evidence-based Complementary and Alternative Medicine

Development of mitochondria-targeted derivatives of resveratrol

(2008) Lucia Biasutto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Mitochondriotropic Derivative of Quercetin: A Strategy to Increase the Effectiveness of Polyphenols

(2008) Andrea Mattarei et al.   CHEMBIOCHEM

Iron Complexation Studies of Gallic Acid

(2008) Ahmed Eid Fazary et al.   JOURNAL OF CHEMICAL AND ENGINEERING DATA

ATP Synthase and the Actions of Inhibitors Utilized To Study Its Roles in Human Health, Disease, and Other Scientific Areas

(2008) S. Hong et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS