Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: An implication of the therapeutic potential

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

Protective role of melatonin in mitochondrial dysfunction and related disorders

(2015) Giuseppe Paradies et al.   ARCHIVES OF TOXICOLOGY

Sulfation of melatonin: Enzymatic characterization, differences of organs, species and genders, and bioactivity variation

(2015) Xiangge Tian et al.   BIOCHEMICAL PHARMACOLOGY

Molecular insights into proton coupled peptide transport in the PTR family of oligopeptide transporters

(2015) Simon Newstead   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Role of electrostatic interactions for ligand recognition and specificity of peptide transporters

(2015) Rajendra Boggavarapu et al.   BMC BIOLOGY

Pharmacokinetic Interactions Between Herbal Medicines and Prescribed Drugs: Focus on Drug Metabolic Enzymes and Transporters

(2015) Qiang Meng et al.   CURRENT DRUG METABOLISM

Interplay of Drug-Metabolizing Enzymes and Transporters in Drug Absorption and Disposition

(2015) Shaojun Shi et al.   CURRENT DRUG METABOLISM

Melatonin: an inhibitor of breast cancer

(2015) S. M. Hill et al.   ENDOCRINE-RELATED CANCER

Melatonin suppression of aerobic glycolysis (Warburg effect), survival signalling and metastasis in human leiomyosarcoma

(2015) Lulu Mao et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as a treatment for gastrointestinal cancer: a review

(2015) Zhenlong Xin et al.   JOURNAL OF PINEAL RESEARCH

Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation

(2015) Jia-Yi Wei et al.   JOURNAL OF PINEAL RESEARCH

Ceramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells

(2015) Raquel Ordoñez et al.   JOURNAL OF PINEAL RESEARCH

Melatonin uptake through glucose transporters: a new target for melatonin inhibition of cancer

(2015) David Hevia et al.   JOURNAL OF PINEAL RESEARCH

Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia

(2015) Cheng-Shi Xu et al.   Journal of Translational Medicine

Molecular aspects of melatonin (MLT)-mediated therapeutic effects

(2015) Hardeep Singh Tuli et al.   LIFE SCIENCES

Functional Expression of PEPT2 in the Human Distal Lung Epithelial Cell Line NCl-H441

(2015) Mikihisa Takano et al.   PHARMACEUTICAL RESEARCH

Gating Topology of the Proton-Coupled Oligopeptide Symporters

(2015) Philip W. Fowler et al.   STRUCTURE

In meso in situserial X-ray crystallography of soluble and membrane proteins

(2015) Chia-Ying Huang et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A review of melatonin in hepatic ischemia/reperfusion injury and clinical liver disease

(2014) Yue Li et al.   ANNALS OF MEDICINE

Tasimelteon

(2014) Jessica D. Johnsa et al.   ANNALS OF PHARMACOTHERAPY

Melatonin: functions and ligands

(2014) Mahaveer Singh et al.   DRUG DISCOVERY TODAY

Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters

(2014) J. A. Lyons et al.   EMBO REPORTS

Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells

(2014) Yunkyung Hong et al.   JOURNAL OF PINEAL RESEARCH

Antitumour activity of melatonin in a mouse model of human prostate cancer: relationship with hypoxia signalling

(2014) Rita Paroni et al.   JOURNAL OF PINEAL RESEARCH

Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review

(2014) Joaquín J. García et al.   JOURNAL OF PINEAL RESEARCH

A review of melatonin as a suitable antioxidant against myocardial ischemia-reperfusion injury and clinical heart diseases

(2014) Yang Yang et al.   JOURNAL OF PINEAL RESEARCH

Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells

(2014) Zhenlong Yu et al.   Molecular Cancer

Enhancement effect of P-gp inhibitors on the intestinal absorption and antiproliferative activity of bestatin

(2013) Xiaokui Huo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Mechanisms Involved in the Pro-Apoptotic Effect of Melatonin in Cancer Cells

(2013) Carmen Rodriguez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proton-coupled oligopeptide transporter family SLC15: Physiological, pharmacological and pathological implications

(2013) David E. Smith et al.   MOLECULAR ASPECTS OF MEDICINE

Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT

(2013) S. Doki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatic and Intestinal Drug Transporters: Prediction of Pharmacokinetic Effects Caused by Drug-Drug Interactions and Genetic Polymorphisms

(2012) Kenta Yoshida et al.   Annual Review of Pharmacology and Toxicology

Renal Transporters in Drug Development

(2012) Kari M. Morrissey et al.   Annual Review of Pharmacology and Toxicology

A novel enzyme-dependent melatonin metabolite in humans

(2012) Chaoyue Li et al.   JOURNAL OF PINEAL RESEARCH

Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes

(2012) Dun-Xian Tan et al.   JOURNAL OF PINEAL RESEARCH

Melatonin membrane receptors in peripheral tissues: Distribution and functions

(2012) Radomir M. Slominski et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Targeted Inactivation of HDAC2 Restores p16INK4a Activity and Exerts Antitumor Effects on Human Gastric Cancer

(2012) J. K. Kim et al.   MOLECULAR CANCER RESEARCH

Expression Profile and Functional Activity of Peptide Transporters in Prostate Cancer Cells

(2012) Wanyi Tai et al.   MOLECULAR PHARMACEUTICS

Drug Transporters in Drug Efficacy and Toxicity

(2011) M.K. DeGorter et al.   Annual Review of Pharmacology and Toxicology

Melatonin has membrane receptor-independent hypnotic action on neurons: an hypothesis

(2011) James E. Jan et al.   JOURNAL OF PINEAL RESEARCH

Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies

(2011) Michael Wilhelmsen et al.   JOURNAL OF PINEAL RESEARCH

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

(2011) Carmen Venegas et al.   JOURNAL OF PINEAL RESEARCH

Melatonin sensitizes human hepatoma cells to endoplasmic reticulum stress-induced apoptosis

(2011) Lixia Zha et al.   JOURNAL OF PINEAL RESEARCH

Transporter-mediated drug–drug interactions

(2011) Fabian Müller et al.   PHARMACOGENOMICS

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

U373-MG cells express PepT2 and accumulate the fluorescently tagged dipeptide-derivative β-Ala-Lys-Nɛ-AMCA

(2010) Mathias Zimmermann et al.   NEUROSCIENCE LETTERS

Therapeutic implications of renal anionic drug transporters

(2010) Rosalinde Masereeuw et al.   PHARMACOLOGY & THERAPEUTICS

Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line

(2008) Javier Martín-Renedo et al.   JOURNAL OF PINEAL RESEARCH

Melatonin uptake in prostate cancer cells: intracellular transport versus simple passive diffusion

(2008) David Hevia et al.   JOURNAL OF PINEAL RESEARCH