Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

(2015) Paolo Bernardi et al.   PHYSIOLOGICAL REVIEWS

Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy

(2014) J Q Kwong et al.   CELL DEATH AND DIFFERENTIATION

NIM811, a cyclophilin inhibitor without immunosuppressive activity, is beneficial in collagen VI congenital muscular dystrophy models

(2014) A. Zulian et al.   HUMAN MOLECULAR GENETICS

F-ATPase ofDrosophila melanogasterForms 53-Picosiemen (53-pS) Channels Responsible for Mitochondrial Ca2+-induced Ca2+Release

(2014) Sophia von Stockum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the Mitochondrial Permeability Transition Pore by the Outer Membrane Does Not Involve the Peripheral Benzodiazepine Receptor (Translocator Protein of 18 kDa (TSPO))

(2014) Justina Šileikytė et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Channel Formation by Yeast F-ATP Synthase and the Role of Dimerization in the Mitochondrial Permeability Transition

(2014) Michela Carraro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cinnamic Anilides as New Mitochondrial Permeability Transition Pore Inhibitors Endowed with Ischemia-Reperfusion Injury Protective Effect in Vivo

(2014) Daniele Fancelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition

(2014) Manuel Gutiérrez-Aguilar et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The role of ligand efficiency metrics in drug discovery

(2014) Andrew L. Hopkins et al.   NATURE REVIEWS DRUG DISCOVERY

Melanocytes from Patients Affected by Ullrich Congenital Muscular Dystrophy and Bethlem Myopathy have Dysfunctional Mitochondria That Can be Rescued with Cyclophilin Inhibitors

(2014) Alessandra Zulian et al.   Frontiers in Aging Neuroscience

What is the nature of the mitochondrial permeability transition poreand What is it Not?

(2013) Detlef Siemen et al.   IUBMB LIFE

Serine Hydrolase Inhibitors Block Necrotic Cell Death by Preventing Calcium Overload of the Mitochondria and Permeability Transition Pore Formation

(2013) Bogeon Yun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptide-based carbon nanotubes for mitochondrial targeting

(2013) Alessia Battigelli et al.   Nanoscale

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mitochondrial permeability transition pore: a mystery solved?

(2013) Paolo Bernardi   Frontiers in Physiology

Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle

(2013) E.P. Taddeo et al.   Molecular Metabolism

Quantification of birefringence readily measures the level of muscle damage in zebrafish

(2012) Joachim Berger et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Small-molecular inhibitors of Ca2+-induced mitochondrial permeability transition (MPT) derived from muscle relaxant dantrolene

(2012) Shinpei Murasawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Activation of the mitochondrial permeability transition pore modulates Ca2+ responses to physiological stimuli in adult neurons

(2011) Anna Barsukova et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mitochondrial calcium and its regulation in neurodegeneration induced by oxidative stress

(2011) Anna G. Barsukova et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cyclosporine A in Ullrich Congenital Muscular Dystrophy: Long-Term Results

(2011) Luciano Merlini et al.   Oxidative Medicine and Cellular Longevity

High Throughput Microplate Respiratory Measurements Using Minimal Quantities Of Isolated Mitochondria

(2011) George W. Rogers et al.   PLoS One

The mitochondrial permeability transition from yeast to mammals

(2010) Luca Azzolin et al.   FEBS LETTERS

Observations on screening-based research and some concerning trends in the literature

(2010) Jonathan B Baell   Future Medicinal Chemistry

Zebrafish models of collagen VI-related myopathies

(2010) W.R. Telfer et al.   HUMAN MOLECULAR GENETICS

Regulation of the Inner Membrane Mitochondrial Permeability Transition by the Outer Membrane Translocator Protein (Peripheral Benzodiazepine Receptor)

(2010) Justina Šileikytė et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting cyclophilin D and the mitochondrial permeability transition enhances  -cell survival and prevents diabetes in Pdx1 deficiency

(2010) K. Fujimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characteristics and possible functions of mitochondrial Ca2+ transport mechanisms

(2009) Thomas E. Gunter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The cyclophilin inhibitor Debio 025 normalizes mitochondrial function, muscle apoptosis and ultrastructural defects inCol6a1−/−myopathic mice

(2009) T Tiepolo et al.   BRITISH JOURNAL OF PHARMACOLOGY

The mitochondrial permeability transition pore in motor neurons: Involvement in the pathobiology of ALS mice

(2009) Lee J. Martin et al.   EXPERIMENTAL NEUROLOGY

Genetic ablation of cyclophilin D rescues mitochondrial defects and prevents muscle apoptosis in collagen VI myopathic mice

(2009) Elena Palma et al.   HUMAN MOLECULAR GENETICS

Exon skipping mutations in collagen VI are common and are predictive for severity and inheritance

(2008) A.K. Lampe et al.   HUMAN MUTATION

The Mitochondrial Phosphate Carrier Interacts with Cyclophilin D and May Play a Key Role in the Permeability Transition

(2008) Anna W. C. Leung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

(2008) Douglas P Millay et al.   NATURE MEDICINE

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Mitochondria: The Hub of Cellular Ca2+ Signaling

(2008) György Szabadkai et al.   PHYSIOLOGY

Cyclosporin A corrects mitochondrial dysfunction and muscle apoptosis in patients with collagen VI myopathies

(2008) Luciano Merlini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA