Calcium signaling as a mediator of cell energy demand and a trigger to cell death

Distinct mPTP activation mechanisms in ischaemia–reperfusion: contributions of Ca2+, ROS, pH, and inorganic polyphosphate

(2015) Lea K. Seidlmayer et al.   CARDIOVASCULAR RESEARCH

CCDC90A (MCUR1) Is a Cytochrome c Oxidase Assembly Factor and Not a Regulator of the Mitochondrial Calcium Uniporter

(2015) Vincent Paupe et al.   Cell Metabolism

The regulation of neuronal mitochondrial metabolism by calcium

(2015) I. Llorente-Folch et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

(2015) Timothy S. Luongo et al.   Cell Reports

The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart

(2015) Jennifer Q. Kwong et al.   Cell Reports

Unresolved questions from the analysis of mice lacking MCU expression

(2014) Elizabeth Murphy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy

(2014) J Q Kwong et al.   CELL DEATH AND DIFFERENTIATION

Essential Role of Mitochondrial Ca2+Uniporter in the Generation of Mitochondrial pH Gradient and Metabolism-Secretion Coupling in Insulin-releasing Cells

(2014) Xianglan Quan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the Mitochondrial Permeability Transition Pore by the Outer Membrane Does Not Involve the Peripheral Benzodiazepine Receptor (Translocator Protein of 18 kDa (TSPO))

(2014) Justina Šileikytė et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition

(2014) Manuel Gutiérrez-Aguilar et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles

(2014) Zoltán Giricz et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Biomarkers distinguish apoptotic and necrotic cell death during hepatic ischemia/reperfusion injury in mice

(2014) Min Yang et al.   LIVER TRANSPLANTATION

SLC25A23 augments mitochondrial Ca2+ uptake, interacts with MCU, and induces oxidative stress–mediated cell death

(2014) Nicholas E. Hoffman et al.   MOLECULAR BIOLOGY OF THE CELL

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

(2014) K. N. Alavian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remote ischaemic preconditioning involves signalling through the SDF-1α/CXCR4 signalling axis

(2013) Sean M. Davidson et al.   BASIC RESEARCH IN CARDIOLOGY

Mitochondrial permeability transition pore is a potential drug target for neurodegeneration

(2013) Valasani Koteswara Rao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of the c subunit of the FOATP synthase in mitochondrial permeability transition

(2013) Massimo Bonora et al.   CELL CYCLE

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

(2013) Anna Raffaello et al.   EMBO JOURNAL

Mechanisms of Hypoxia Responses in Renal Tissue

(2013) V. H. Haase   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling

(2013) Clare V Logan et al.   NATURE GENETICS

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity

(2013) Nicholas E. Hoffman et al.   Cell Reports

MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

(2012) Karthik Mallilankaraman et al.   CELL

Physiological Roles of the Permeability Transition Pore

(2012) Catherine Brenner et al.   CIRCULATION RESEARCH

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

(2012) Karthik Mallilankaraman et al.   NATURE CELL BIOLOGY

Protective Role of Transient Pore Openings in Calcium Handling by Cardiac Mitochondria

(2011) Paavo Korge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The roles of phosphate and the phosphate carrier in the mitochondrial permeability transition pore

(2011) Pinadda Varanyuwatana et al.   MITOCHONDRION

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

The role of Cyclophilin D in learning and memory

(2010) Akihiro Mouri et al.   HIPPOCAMPUS

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

(2010) Fabiana Perocchi et al.   NATURE

Targeting cyclophilin D and the mitochondrial permeability transition enhances  -cell survival and prevents diabetes in Pdx1 deficiency

(2010) K. Fujimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic ablation of cyclophilin D rescues mitochondrial defects and prevents muscle apoptosis in collagen VI myopathic mice

(2009) Elena Palma et al.   HUMAN MOLECULAR GENETICS

Regulating RISK: a role for JAK-STAT signaling in postconditioning?

(2008) Michael D. Goodman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY