Melatonin Balance the Autophagy and Apoptosis by Regulating UCP2 in the LPS-Induced Cardiomyopathy

Melatonin increases brown adipose tissue mass and function in Zücker diabetic fatty rats: implications for obesity control

(2018) Gumersindo Fernández Vázquez et al.   JOURNAL OF PINEAL RESEARCH

Protective effects of heme oxygenase-1-transduced bone marrow-derived mesenchymal stem cells on reduced-size liver transplantation: Role of autophagy regulated by the ERK/mTOR signaling pathway

(2017) Raorao Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer

(2017) Guangbo Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cytoprotective Effect of the UCP2-SIRT3 Signaling Pathway by Decreasing Mitochondrial Oxidative Stress on Cerebral Ischemia–Reperfusion Injury

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Crosstalk of autophagy and apoptosis: Involvement of the dual role of autophagy under ER stress

(2017) Shuling Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitochondrial Uncoupling Protein 2 in human cumulus cells is associated with regulating autophagy and apoptosis, maintaining gap junction integrity and progesterone synthesis

(2017) Hongshan Ge et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A randomised trial on the effect of anti-platelet therapy on the systemic inflammatory response in human endotoxaemia

(2017) Dorien Kiers et al.   THROMBOSIS AND HAEMOSTASIS

Sepsis-Induced Cardiomyopathy: Mechanisms and Treatments

(2017) Yan-Cun Liu et al.   Frontiers in Immunology

Autophagy in sepsis: Degradation into exhaustion?

(2016) Jeffery Ho et al.   Autophagy

Uncoupling protein 2 deficiency results in higher neutrophil counts and lower B-cell counts during aging in mice

(2016) Christin Kretzschmar et al.   EXPERIMENTAL HEMATOLOGY

Mitochondrial involvement in myocyte death and heart failure

(2016) Michael J. Goldenthal   HEART FAILURE REVIEWS

Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics

(2016) Dun-Xian Tan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Uncoupling Protein 2 Increases Susceptibility to Lipopolysaccharide-Induced Acute Lung Injury in Mice

(2016) Qin Wang et al.   MEDIATORS OF INFLAMMATION

Mechanism of uncoupling protein 2-mediated myocardial injury in hypothermic preserved rat hearts

(2016) Gai-Ge Chen et al.   Molecular Medicine Reports

Silencing of uncoupling protein 2 by small interfering RNA aggravates mitochondrial dysfunction in cardiomyocytes under septic conditions

(2015) GUILANG ZHENG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis

(2015) Jong-Seok Moon et al.   JOURNAL OF CLINICAL INVESTIGATION

Melatonin reduces hepatic mitochondrial dysfunction in diabetic obese rats

(2015) Ahmad Agil et al.   JOURNAL OF PINEAL RESEARCH

Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto(mito)phagy markers

(2015) I. Marques-Aleixo et al.   NEUROSCIENCE

The Role of Uncoupling Protein 2 During Myocardial Dysfunction in a Canine Model of Endotoxin Shock

(2015) Xiaoting Wang et al.   SHOCK

The Protective Effect of Melatonin on Neural Stem Cell against LPS-Induced Inflammation

(2015) Juhyun Song et al.   Biomed Research International

Beclin 1 knockdown retards re-endothelialization and exacerbates neointimal formation via a crosstalk between autophagy and apoptosis

(2014) Lan-Xiang Ye et al.   ATHEROSCLEROSIS

Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart

(2014) Alexander T. Akhmedov et al.   HEART FAILURE REVIEWS

14-3-3γ protein attenuates lipopolysaccharide-induced cardiomyocytes injury through the Bcl-2 family/mitochondria pathway

(2014) Dan Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Melatonin as a potential therapy for sepsis: a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsis

(2014) Helen F. Galley et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and metabolic regulation: a review

(2014) Miguel Navarro-Alarcón et al.   Food & Function

Uncoupling Protein 2 Regulates Palmitic Acid-Induced Hepatoma Cell Autophagy

(2014) Jiaxin Lou et al.   Biomed Research International

UCP2, a mitochondrial protein regulated at multiple levels

(2013) Massimo Donadelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Melatonin induces browning of inguinal white adipose tissue in Zucker diabetic fatty rats

(2013) Aroa Jiménez-Aranda et al.   JOURNAL OF PINEAL RESEARCH

Expressional profile of cardiac uncoupling protein-2 following myocardial ischemia reperfusion in losartan- and ramiprilat-treated rats

(2013) Fatemeh Safari et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process

(2012) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Insufficient Autophagy Contributes to Mitochondrial Dysfunction, Organ Failure, and Adverse Outcome in an Animal Model of Critical Illness*

(2012) Jan Gunst et al.   CRITICAL CARE MEDICINE

Cardiac-specific overexpression of catalase attenuates lipopolysaccharide-induced myocardial contractile dysfunction: Role of autophagy

(2012) Subat Turdi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin improved rat cardiac mitochondria and survival rate in septic heart injury

(2012) Hongmin Zhang et al.   JOURNAL OF PINEAL RESEARCH

Further Support to the Uncoupling-to-Survive Theory: The Genetic Variation of Human UCP Genes Is Associated with Longevity

(2011) Giuseppina Rose et al.   PLoS One

Animal models of mitochondrial DNA transactions in disease and ageing

(2010) Marcos T. Oliveira et al.   EXPERIMENTAL GERONTOLOGY

Sepsis-induced cardiomyopathy: a review of pathophysiologic mechanisms

(2010) Anthony Flynn et al.   HEART FAILURE REVIEWS

The Role of Uncoupling Protein 2 in the Apoptosis Induced by Free Fatty Acid in Rat Cardiomyocytes

(2010) Nan Li et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Down-regulated energy metabolism genes associated with mitochondria oxidative phosphorylation and fatty acid metabolism in viral cardiomyopathy mouse heart

(2010) Jing Xu et al.   MOLECULAR BIOLOGY REPORTS

p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation

(2010) R. Scherz-Shouval et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis

(2010) Yushan Zhu et al.   Protein & Cell

Targeted expression of uncoupling protein 2 to mouse liver increases the susceptibility to lipopolysaccharide/galactosamine-induced acute liver injury

(2009) Yingli Shang et al.   HEPATOLOGY

Uncoupling protein 2 regulates reactive oxygen species formation in islets and influences susceptibility to diabetogenic action of streptozotocin

(2009) Simon C Lee et al.   JOURNAL OF ENDOCRINOLOGY

Uncoupling protein-2 deficiency provides protection in a murine model of endotoxemic acute liver failure

(2008) Khoi Le Minh et al.   CRITICAL CARE MEDICINE