Hereditary Spastic Paraplegia and Future Therapeutic Directions: Beneficial Effects of Small Compounds Acting on Cellular Stress

The rapidly evolving view of lysosomal storage diseases

(2021) Giancarlo Parenti et al.   EMBO Molecular Medicine

Resveratrol promotes lysosomal function via ER calcium-dependent TFEB activation to ameliorate lipid accumulation

(2021) Rong Shao et al.   BIOCHEMICAL JOURNAL

ER-Phagy: Quality Control and Turnover of Endoplasmic Reticulum

(2020) Haruka Chino et al.   TRENDS IN CELL BIOLOGY

Axonal Endoplasmic Reticulum Dynamics and Its Roles in Neurodegeneration

(2020) Zeynep Öztürk et al.   Frontiers in Neuroscience

Lipids in the Physiopathology of Hereditary Spastic Paraplegias

(2020) Frédéric Darios et al.   Frontiers in Neuroscience

Efficacy of a Combined Treatment of Botulinum Toxin and Intensive Physiotherapy in Hereditary Spastic Paraplegia

(2020) Gabriella Paparella et al.   Frontiers in Neuroscience

Spastin mutations impair coordination between lipid droplet dispersion and reticulum

(2020) Yoan Arribat et al.   PLoS Genetics

Oxidative Stress-Induced Axon Fragmentation Is a Consequence of Reduced Axonal Transport in Hereditary Spastic Paraplegia SPAST Patient Neurons

(2020) Gautam Wali et al.   Frontiers in Neuroscience

Pharmacokinetics and Metabolism of Naringin and Active Metabolite Naringenin in Rats, Dogs, Humans, and the Differences Between Species

(2020) Yang Bai et al.   Frontiers in Pharmacology

Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis

(2020) Nimesha Tadepalle et al.   Life Science Alliance

TFG is required for autophagy flux and to prevent endoplasmic reticulum stress in CH12 B lymphoma cells

(2020) Tobit D. Steinmetz et al.   Autophagy

Inhibition of ER stress improves progressive motor deficits in a REEP1-null mouse model of hereditary spastic paraplegia

(2020) Bingjie Wang et al.   Biology Open

Lipid Transfer–Dependent Endosome Maturation Mediated by Protrudin and PDZD8 in Neurons

(2020) Michiko Shirane   Frontiers in Cell and Developmental Biology

Lipid Droplet Nucleation

(2020) Abdou Rachid Thiam et al.   TRENDS IN CELL BIOLOGY

Rapamycin: A Bacteria-Derived Immunosuppressant That Has Anti-atherosclerotic Effects and Its Clinical Application

(2019) Yandong Liu et al.   Frontiers in Pharmacology

Management of Hereditary Spastic Paraplegia: A Systematic Review of the Literature

(2019) Marta Bellofatto et al.   Frontiers in Neurology

Neutral Lipid Storage Diseases as Cellular Model to Study Lipid Droplet Function

(2019) Sara Missaglia et al.   Cells

A mouse model for SPG48 reveals a block of autophagic flux upon disruption of adaptor protein complex five

(2019) Mukhran Khundadze et al.   NEUROBIOLOGY OF DISEASE

Methylene Blue Inhibits Formation of Tau Fibrils but not of Granular Tau Oligomers: A Plausible Key to Understanding Failure of a Clinical Trial for Alzheimer’s Disease

(2019) Yoshiyuki Soeda et al.   JOURNAL OF ALZHEIMERS DISEASE

Update on the Genetics of Spastic Paraplegias

(2019) Maxime Boutry et al.   Current Neurology and Neuroscience Reports

ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling

(2019) Wei Zheng et al.   Cell Communication and Signaling

Lysosomal diseases: Overview on current diagnosis and treatment

(2019) Fabiano de Oliveira Poswar et al.   GENETICS AND MOLECULAR BIOLOGY

Flavonoids Regulate Lipid Droplets Biogenesis in Drosophila melanogaster

(2019) Marianna Fantin et al.   Natural Product Communications

Inadequate BiP availability defines endoplasmic reticulum stress

(2019) Milena Vitale et al.   eLife

N‐Acetyl Cysteine Is Associated With Dopaminergic Improvement in Parkinson's Disease

(2019) Daniel A. Monti et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Methylene blue elicits non-genotoxic H2O2 production and protects brain mitochondria from rotenone toxicity

(2019) Artem P. Gureev et al.   Journal of Applied Biomedicine

Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III

(2019) Chi-Lun Chang et al.   JOURNAL OF CELL BIOLOGY

Hereditary spastic paraplegia: from diagnosis to emerging therapeutic approaches

(2019) Samuel Shribman et al.   LANCET NEUROLOGY

Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP patient-specific neurons

(2019) Kristina Rehbach et al.   Scientific Reports

Safety and pharmacokinetics of naringenin: A randomized, controlled, single‐ascending‐dose clinical trial

(2019) Candida J. Rebello et al.   DIABETES OBESITY & METABOLISM

Emerging lysosomal pathways for quality control at the endoplasmic reticulum

(2019) Chiara De Leonibus et al.   FEBS LETTERS

ESCRT-III-associated proteins and spastin inhibit protrudin-dependent polarised membrane traffic

(2019) James W. Connell et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Naringenin complexed with hydroxypropyl-β-cyclodextrin improves the sciatic nerve regeneration through inhibition of p75NTR and JNK pathway

(2019) Marlange A. Oliveira et al.   LIFE SCIENCES

NeurodegenERation: The Central Role for ER Contacts in Neuronal Function and Axonopathy, Lessons From Hereditary Spastic Paraplegias and Related Diseases

(2019) Philippa C. Fowler et al.   Frontiers in Neuroscience

Naringenin Ameliorates Drosophila ReepA Hereditary Spastic Paraplegia-Linked Phenotypes

(2019) Barbara Napoli et al.   Frontiers in Neuroscience

On the Neuroprotective Effects of Naringenin: Pharmacological Targets, Signaling Pathways, Molecular Mechanisms, and Clinical Perspective

(2019) Nouri et al.   Biomolecules

ER morphology and endo-lysosomal crosstalk: Functions and disease implications

(2019) Crystal A. Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Novel compounds for the modulation of mTOR and autophagy to treat neurodegenerative diseases

(2019) David Heras-Sandoval et al.   CELLULAR SIGNALLING

Therapies for rare diseases: therapeutic modalities, progress and challenges ahead

(2019) Erik Tambuyzer et al.   NATURE REVIEWS DRUG DISCOVERY

Microtubules Stabilization by Mutant Spastin Affects ER Morphology and Ca2+ Handling

(2019) Nicola Vajente et al.   Frontiers in Physiology

Efficacy and safety of methylene blue in the treatment of malaria: a systematic review

(2018) G. Lu et al.   BMC Medicine

Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease

(2018) Xiaotian Sun et al.   EXPERIMENTAL NEUROLOGY

Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications

(2018) Aitor Almanza et al.   FEBS Journal

Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions

(2018) Dijin Xu et al.   JOURNAL OF CELL BIOLOGY

Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways

(2018) Jiwon Hwang et al.   TRENDS IN BIOCHEMICAL SCIENCES

A checklist for clinical trials in rare disease: obstacles and anticipatory actions—lessons learned from the FOR-DMD trial

(2018) Rebecca A. Crow et al.   Trials

Beneficial effects of naringenin in liver diseases: Molecular mechanisms

(2018) Erika Hernández-Aquino et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Inhibition of Lysosome Membrane Recycling Causes Accumulation of Gangliosides that Contribute to Neurodegeneration

(2018) Maxime Boutry et al.   Cell Reports

Role of the AP-5 adaptor protein complex in late endosome-to-Golgi retrieval

(2018) Jennifer Hirst et al.   PLOS BIOLOGY

ZFYVE26/SPASTIZIN and SPG11/SPATACSIN mutations in hereditary spastic paraplegia types AR-SPG15 and AR-SPG11 have different effects on autophagy and endocytosis

(2018) Chiara Vantaggiato et al.   Autophagy

Expression of N471D strumpellin leads to defects in the endolysosomal system

(2018) Lin Song et al.   Disease Models & Mechanisms

Miglustat in Niemann-Pick disease type C patients: a review

(2018) Mercè Pineda et al.   Orphanet Journal of Rare Diseases

Pharmacokinetic, pharmacodynamic and formulations aspects of Naringenin: An update

(2018) Ruthvika Joshi et al.   LIFE SCIENCES

Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases

(2018) Giuseppe Tardiolo et al.   MOLECULES

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

N-Acetylcysteine for the Treatment of Psychiatric Disorders: A Review of Current Evidence

(2018) Soo Liang Ooi et al.   Biomed Research International

Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons

(2018) Tatyana Pozner et al.   Frontiers in Neuroscience

Clinical Trial Designs and Measures in Hereditary Spastic Paraplegias

(2018) Brian Trummer et al.   Frontiers in Neurology

Can Co-Activation of Nrf2 and Neurotrophic Signaling Pathway Slow Alzheimer’s Disease?

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proteome Stability as a Key Factor of Genome Integrity

(2017) Sentiljana Gumeni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Defects in ER–endosome contacts impact lysosome function in hereditary spastic paraplegia

(2017) Rachel Allison et al.   JOURNAL OF CELL BIOLOGY

Lipid Droplets in Health and Disease

(2017) Gizem Onal et al.   Lipids in Health and Disease

Methylene blue and its analogues as antidepressant compounds

(2017) Anzelle Delport et al.   METABOLIC BRAIN DISEASE

From Mitochondrial Function to Neuroprotection—an Emerging Role for Methylene Blue

(2017) Donovan Tucker et al.   MOLECULAR NEUROBIOLOGY

Contacts between the endoplasmic reticulum and other membranes in neurons

(2017) Yumei Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hereditary spastic paraplegia: More than an upper motor neuron disease

(2017) L. Parodi et al.   REVUE NEUROLOGIQUE

Protein misfolding, amyotrophic lateral sclerosis and guanabenz: protocol for a phase II RCT with futility design (ProMISe trial)

(2017) Eleonora Dalla Bella et al.   BMJ Open

Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins

(2017) Belgin Yalçın et al.   eLife

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

(2017) Paolo Grumati et al.   eLife

PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz

(2017) Ana Crespillo-Casado et al.   eLife

Naringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis

(2017) Irene Pafumi et al.   Scientific Reports

Late-onset Alzheimer’s disease is associated with inherent changes in bioenergetics profiles

(2017) Kai-C. Sonntag et al.   Scientific Reports

The formation and function of ER-endosome membrane contact sites

(2016) Emily R. Eden   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Seipin regulates ER–lipid droplet contacts and cargo delivery

(2016) Veijo T Salo et al.   EMBO JOURNAL

Hereditary spastic paraplegias: identification of a novel SPG57 variant affecting TFG oligomerization and description of HSP subtypes in Sudan

(2016) Liena E O Elsayed et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

N-acetylcysteine in the treatment of psychiatric disorders: current status and future prospects

(2016) Alessandro Minarini et al.   Expert Opinion on Drug Metabolism & Toxicology

Conserved pharmacological rescue of hereditary spastic paraplegia-related phenotypes across model organisms

(2016) Carl Julien et al.   HUMAN MOLECULAR GENETICS

Reep1null mice reveal a converging role for hereditary spastic paraplegia proteins in lipid droplet regulation

(2016) Benoît Renvoisé et al.   HUMAN MOLECULAR GENETICS

Drug Discovery in Fish, Flies, and Worms

(2016) Kevin Strange   ILAR JOURNAL

Lipid droplet–mediated ER homeostasis regulates autophagy and cell survival during starvation

(2016) Ariadna P. Velázquez et al.   JOURNAL OF CELL BIOLOGY

Beneficial effects of rapamycin in aDrosophilamodel for hereditary spastic paraplegia

(2016) Shiyu Xu et al.   JOURNAL OF CELL SCIENCE

N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data

(2016) Daniel A. Monti et al.   PLoS One

ER stress: Autophagy induction, inhibition and selection

(2015) Harun-Or Rashid et al.   Autophagy

ER-endosome contact sites: molecular compositions and functions

(2015) C. Raiborg et al.   EMBO JOURNAL

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Loss of AP-5 results in accumulation of aberrant endolysosomes: defining a new type of lysosomal storage disease

(2015) Jennifer Hirst et al.   HUMAN MOLECULAR GENETICS

l-Cysteine metabolism and its nutritional implications

(2015) Jie Yin et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Repeated ER–endosome contacts promote endosome translocation and neurite outgrowth

(2015) Camilla Raiborg et al.   NATURE

Structure and function of ER membrane contact sites with other organelles

(2015) Melissa J. Phillips et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11

(2015) Rita-Eva Varga et al.   PLoS Genetics

Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau

(2015) Katja Hochgräfe et al.   Acta Neuropathologica Communications

Loss of Association of REEP2 with Membranes Leads to Hereditary Spastic Paraplegia

(2014) Typhaine Esteves et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ER Contact Sites Define the Position and Timing of Endosome Fission

(2014) Ashley A. Rowland et al.   CELL

Functional Mutation Analysis Provides Evidence for a Role of REEP1 in Lipid Droplet Biology

(2014) Julia Falk et al.   HUMAN MUTATION

Protrudin Regulates Endoplasmic Reticulum Morphology and Function Associated with the Pathogenesis of Hereditary Spastic Paraplegia

(2014) Yutaka Hashimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER stress signaling requires RHD3, a functionally conserved ER-shaping GTPase

(2014) Ya-Shiuan Lai et al.   JOURNAL OF CELL SCIENCE

Small regulators, major consequences - Ca2+ and cholesterol at the endosome-ER interface

(2014) R. van der Kant et al.   JOURNAL OF CELL SCIENCE

Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation

(2014) Jaerak Chang et al.   JOURNAL OF CLINICAL INVESTIGATION

Herp coordinates compartmentalization and recruitment of HRD1 and misfolded proteins for ERAD

(2014) Julia Leitman et al.   MOLECULAR BIOLOGY OF THE CELL

Proteostasis in endoplasmic reticulum—new mechanisms in kidney disease

(2014) Reiko Inagi et al.   Nature Reviews Nephrology

Evidence of TRK-Fused Gene (TFG1) function in the ubiquitin–proteasome system

(2014) Takuya Yagi et al.   NEUROBIOLOGY OF DISEASE

Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis

(2014) H.-Q. Jiang et al.   NEUROSCIENCE

A model for the generation and interconversion of ER morphologies

(2014) Tom Shemesh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal abnormalities in hereditary spastic paraplegia types SPG15 and SPG11

(2014) Benoît Renvoisé et al.   Annals of Clinical and Translational Neurology

The chemistry and biological activities of N-acetylcysteine

(2013) Yuval Samuni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Defective autophagy in spastizin mutated patients with hereditary spastic paraparesis type 15

(2013) Chiara Vantaggiato et al.   BRAIN

Preparation and characterization of inclusion complexes of naringenin with β-cyclodextrin or its derivative

(2013) Li-Juan Yang et al.   CARBOHYDRATE POLYMERS

ER structure and function

(2013) Shuliang Chen et al.   CURRENT OPINION IN CELL BIOLOGY

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

(2013) Florian Wilfling et al.   DEVELOPMENTAL CELL

It may be possible to delay the onset of neurodegenerative diseases with an immunosuppressive drug (rapamycin)

(2013) Ester Aso et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Bidirectional Ca2+signaling occurs between the endoplasmic reticulum and acidic organelles

(2013) Anthony J. Morgan et al.   JOURNAL OF CELL BIOLOGY

Expression of oleosin and perilipins in yeast promotes formation of lipid droplets from the endoplasmic reticulum

(2013) N. Jacquier et al.   JOURNAL OF CELL SCIENCE

Clinical Trials in Rare Disease

(2013) Erika F. Augustine et al.   JOURNAL OF CHILD NEUROLOGY

Minireview: Endoplasmic Reticulum Stress: Control in Protein, Lipid, and Signal Homeostasis

(2013) József Mandl et al.   MOLECULAR ENDOCRINOLOGY

Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo

(2013) Alexandra Vaccaro et al.   NEUROBIOLOGY OF DISEASE

Therapeutic and preventive effects of methylene blue on Alzheimer's disease pathology in a transgenic mouse model

(2013) V. Paban et al.   NEUROPHARMACOLOGY

A Conserved Role for Atlastin GTPases in Regulating Lipid Droplet Size

(2013) Robin W. Klemm et al.   Cell Reports

Reticulon-like-1, the Drosophila orthologue of the Hereditary Spastic Paraplegia gene reticulon 2, is required for organization of endoplasmic reticulum and of distal motor axons

(2012) N. C. O'Sullivan et al.   HUMAN MOLECULAR GENETICS

Direct mobilisation of lysosomal Ca 2+ triggers complex Ca 2+ signals

(2012) Bethan S. Kilpatrick et al.   JOURNAL OF CELL SCIENCE

Endoplasmic Reticulum Stress Is Important for the Manifestations of  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Endoplasmic reticulum dysfunction in neurological disease

(2012) Benoit D Roussel et al.   LANCET NEUROLOGY

Progressive sheet-to-tubule transformation is a general mechanism for endoplasmic reticulum partitioning in dividing mammalian cells

(2012) Maija Puhka et al.   MOLECULAR BIOLOGY OF THE CELL

Naringenin ameliorates Alzheimer’s disease (AD)-type neurodegeneration with cognitive impairment (AD-TNDCI) caused by the intracerebroventricular-streptozotocin in rat model

(2012) M. Badruzzaman Khan et al.   NEUROCHEMISTRY INTERNATIONAL

Methylene blue administration fails to confer neuroprotection in two amyotrophic lateral sclerosis mouse models

(2012) J.-N. Audet et al.   NEUROSCIENCE

Reticulon 3 attenuates the clearance of cytosolic prion aggregates via inhibiting autophagy

(2011) Rui Chen et al.   Autophagy

Rapamycin treatment augments motor neuron degeneration in SOD1G93Amouse model of amyotrophic lateral sclerosis

(2011) Xiaojie Zhang et al.   Autophagy

The size and phospholipid composition of lipid droplets can influence their proteome

(2011) Weihua Fei et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nutritional Antioxidants and Adaptive Cell Responses: An Update

(2011) A. Speciale et al.   CURRENT MOLECULAR MEDICINE

Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease

(2011) M. C. Barone et al.   Disease Models & Mechanisms

Alternative Mitochondrial Electron Transfer as a Novel Strategy for Neuroprotection

(2011) Yi Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A 3D analysis of yeast ER structure reveals how ER domains are organized by membrane curvature

(2011) Matt West et al.   JOURNAL OF CELL BIOLOGY

Spartin recruits PKC-ζ via the PKC-ζ-interacting proteins ZIP1 and ZIP3 to lipid droplets

(2011) Andreas Urbanczyk et al.   JOURNAL OF NEUROCHEMISTRY

TFG-1 function in protein secretion and oncogenesis

(2011) Kristen Witte et al.   NATURE CELL BIOLOGY

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

“Lest we forget you — methylene blue …”

(2011) R. Heiner Schirmer et al.   NEUROBIOLOGY OF AGING

Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway

(2011) Xiumei Huang et al.   NEUROBIOLOGY OF AGING

Glutamatergic medications for the treatment of drug and behavioral addictions

(2011) M. Foster Olive et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

GTP-dependent packing of a three-helix bundle is required for atlastin-mediated fusion

(2011) D. Pendin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue

(2011) Julio C. Rojas et al.   PROGRESS IN NEUROBIOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Tissue-Autonomous Function of Drosophila Seipin in Preventing Ectopic Lipid Droplet Formation

(2011) Yuan Tian et al.   PLoS Genetics

Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets

(2010) Christopher Hooper et al.   BMC BIOLOGY

TOR on the brain

(2010) Michael G. Garelick et al.   EXPERIMENTAL GERONTOLOGY

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Transmembrane domain length is responsible for the ability of a plant reticulon to shape endoplasmic reticulum tubules in vivo

(2010) Nicholas Tolley et al.   PLANT JOURNAL

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Reticulon Short Hairpin Transmembrane Domains Are Used to Shape ER Tubules

(2010) Nesia Zurek et al.   TRAFFIC

Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5

(2009) Thomas L. Edwards et al.   BIOCHEMICAL JOURNAL

Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3

(2009) Fiona M. Menzies et al.   BRAIN

A Class of Dynamin-like GTPases Involved in the Generation of the Tubular ER Network

(2009) Junjie Hu et al.   CELL

Peripheral ER structure and function

(2009) Amber R English et al.   CURRENT OPINION IN CELL BIOLOGY

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover

(2009) Scott W. Eastman et al.   JOURNAL OF CELL BIOLOGY

Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response

(2009) Sebastian Schuck et al.   JOURNAL OF CELL BIOLOGY

Homotypic fusion of ER membranes requires the dynamin-like GTPase Atlastin

(2009) Genny Orso et al.   NATURE

A role for motoneuron subtype–selective ER stress in disease manifestations of FALS mice

(2009) Smita Saxena et al.   NATURE NEUROSCIENCE

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

High absolute bioavailability of methylene blue given as an aqueous oral formulation

(2008) Ingeborg Walter-Sack et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Protein Folding Activity of Ribosomal RNA Is a Selective Target of Two Unrelated Antiprion Drugs

(2008) Déborah Tribouillard-Tanvier et al.   PLoS One

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways

(2007) Hani Atamna et al.   FASEB JOURNAL

(+/−)-Naringenin as large conductance Ca2+-activated K+ (BKCa) channel opener in vascular smooth muscle cells

(2006) S Saponara et al.   BRITISH JOURNAL OF PHARMACOLOGY