Resveratrol promotes lysosomal function via ER calcium-dependent TFEB activation to ameliorate lipid accumulation

Resveratrol protects Lactobacillus reuteri against H2O2- induced oxidative stress and stimulates antioxidant defenses through upregulation of the dhaT gene

(2019) Narciza O. Arcanjo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resveratrol protects against nonalcoholic fatty liver disease by improving lipid metabolism and redox homeostasis via the PPARα pathway

(2019) Yujie Huang et al.   Applied Physiology Nutrition and Metabolism

Resveratrol attenuates endothelial oxidative injury by inducing autophagy via the activation of transcription factor EB

(2019) Xi Zhou et al.   Nutrition & Metabolism

Cellular endo‐lysosomal dysfunction in the pathogenesis of non‐alcoholic fatty liver disease

(2019) Jiang Du et al.   LIVER INTERNATIONAL

Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress

(2018) José A. Martina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of resveratrol on lipid profile: An updated systematic review and meta-analysis on randomized clinical trials

(2018) Fahimeh Haghighatdoost et al.   PHARMACOLOGICAL RESEARCH

ER stress regulating protein phosphatase 2A-B56γ, targeted by hepatitis B virus X protein, induces cell cycle arrest and apoptosis of hepatocytes

(2018) Chengyong He et al.   Cell Death & Disease

Resveratrol Sensitizes Carfilzomib-Induced Apoptosis via Promoting Oxidative Stress in Multiple Myeloma Cells

(2018) Qian Li et al.   Frontiers in Pharmacology

Lysosomal Ion Channels as Decoders of Cellular Signals

(2018) Ping Li et al.   TRENDS IN BIOCHEMICAL SCIENCES

In vitro assessment of the indirect antioxidant activity of Sulforaphane in redox imbalance vanadium-induced

(2017) Giuseppa Visalli et al.   NATURAL PRODUCT RESEARCH

Resveratrol ameliorates lipid accumulation in HepG2 cells, associated with down-regulation of lipin1 expression

(2016) Li Ying Tang et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

(2016) Xiaoli Zhang et al.   Nature Communications

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

PI(5)P Regulates Autophagosome Biogenesis

(2015) Mariella Vicinanza et al.   MOLECULAR CELL

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Resveratrol increases antioxidant defenses and decreases proinflammatory cytokines in hippocampal astrocyte cultures from newborn, adult and aged Wistar rats

(2014) Bruna Bellaver et al.   TOXICOLOGY IN VITRO

RRAG GTPases link nutrient availability to gene expression, autophagy and lysosomal biogenesis

(2013) Jose A. Martina et al.   Autophagy

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

A RANKL-PKC -TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts

(2013) M. Ferron et al.   GENES & DEVELOPMENT

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice

(2010) Wen–Xing Ding et al.   GASTROENTEROLOGY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase

(2008) Jing SHANG et al.   ACTA PHARMACOLOGICA SINICA

Beneficial Effects of Resveratrol on Atherosclerosis

(2008) Enguo Fan et al.   JOURNAL OF MEDICINAL FOOD

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE