Spastin mutations impair coordination between lipid droplet dispersion and reticulum

The Rice SPOTTED LEAF4 (SPL4) Encodes a Plant Spastin That Inhibits ROS Accumulation in Leaf Development and Functions in Leaf Senescence

(2019) Giha Song et al.   Frontiers in Plant Science

KIF1A variants are a frequent cause of autosomal dominant hereditary spastic paraplegia

(2019) Maartje Pennings et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The Inner Nuclear Membrane Is a Metabolically Active Territory that Generates Nuclear Lipid Droplets

(2018) Anete Romanauska et al.   CELL

Lipid Droplet, a Key Player in Host-Parasite Interactions

(2018) Adriana Lima Vallochi et al.   Frontiers in Immunology

Distinct patterns of skeletal muscle mitochondria fusion, fission and mitophagy upon duration of exercise training

(2018) Yoan Arribat et al.   Acta Physiologica

BMP- and neuropilin 1-mediated motor axon navigation relies on spastin alternative translation

(2018) Nicolas Jardin et al.   DEVELOPMENT

Functional differences of short and long isoforms of spastin harboring missense mutation

(2018) Clément Plaud et al.   Disease Models & Mechanisms

GTP hydrolysis promotes disassembly of the atlastin crossover dimer during ER fusion

(2018) James Winsor et al.   JOURNAL OF CELL BIOLOGY

Lipid Droplets in Cancer: Guardians of Fat in a Stressful World

(2018) Toni Petan et al.   MOLECULES

Developmentally regulated H2Av buffering via dynamic sequestration to lipid droplets in Drosophila embryos

(2018) Matthew Richard Johnson et al.   eLife

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Moving out but keeping in touch: contacts between endoplasmic reticulum and lipid droplets

(2018) Veijo T Salo et al.   CURRENT OPINION IN CELL BIOLOGY

Mutant spastin proteins promote deficits in axonal transport through an isoform-specific mechanism involving casein kinase 2 activation

(2017) Lanfranco Leo et al.   HUMAN MOLECULAR GENETICS

Pet10p is a yeast perilipin that stabilizes lipid droplets and promotes their assembly

(2017) Qiang Gao et al.   JOURNAL OF CELL BIOLOGY

The why, when and how of lipid droplet diversity

(2017) Abdou Rachid Thiam et al.   JOURNAL OF CELL SCIENCE

Lipid Droplets in Health and Disease

(2017) Gizem Onal et al.   Lipids in Health and Disease

Applying systems-level spectral imaging and analysis to reveal the organelle interactome

(2017) Alex M. Valm et al.   NATURE

Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease

(2017) Dhaval Patel et al.   Oxidative Medicine and Cellular Longevity

Kinesin-dependent mechanism for controlling triglyceride secretion from the liver

(2017) Priyanka Rai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zebrafish lipid droplets regulate embryonic ATP homeostasis to power early development

(2017) Asmita Dutta et al.   Open Biology

Tau and tauopathies

(2016) Thomas Arendt et al.   BRAIN RESEARCH BULLETIN

Seipin regulates ER–lipid droplet contacts and cargo delivery

(2016) Veijo T Salo et al.   EMBO JOURNAL

Lipid droplet–mediated ER homeostasis regulates autophagy and cell survival during starvation

(2016) Ariadna P. Velázquez et al.   JOURNAL OF CELL BIOLOGY

Temporal control of bidirectional lipid-droplet motion inDrosophiladepends on the ratio of kinesin-1 and its co-factor Halo

(2016) Gurpreet K. Arora et al.   JOURNAL OF CELL SCIENCE

BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks

(2016) Carlos M. Guardia et al.   Cell Reports

Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network

(2016) Songyu Wang et al.   eLife

A transgenic zebrafish model for monitoring xbp1 splicing and endoplasmic reticulum stress in vivo

(2015) Junling Li et al.   MECHANISMS OF DEVELOPMENT

Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology

(2015) Bethany R. Cartwright et al.   MOLECULAR BIOLOGY OF THE CELL

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

(2015) Marina Vietri et al.   NATURE

AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation

(2015) Albert Herms et al.   Nature Communications

Spastin Binds to Lipid Droplets and Affects Lipid Metabolism

(2015) Chrisovalantis Papadopoulos et al.   PLoS Genetics

Hereditary spastic paraplegia: Clinical-genetic characteristics and evolving molecular mechanisms

(2014) Temistocle Lo Giudice et al.   EXPERIMENTAL NEUROLOGY

Functional Mutation Analysis Provides Evidence for a Role of REEP1 in Lipid Droplet Biology

(2014) Julia Falk et al.   HUMAN MUTATION

Protrudin Regulates Endoplasmic Reticulum Morphology and Function Associated with the Pathogenesis of Hereditary Spastic Paraplegia

(2014) Yutaka Hashimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic Mutation of Spastin Has Gain-of-Function Effects on Microtubule Dynamics

(2014) J. M. Solowska et al.   JOURNAL OF NEUROSCIENCE

The rice (Oryza sativa L.) LESION MIMIC RESEMBLING, which encodes an AAA-type ATPase, is implicated in defense response

(2014) Rym Fekih et al.   MOLECULAR GENETICS AND GENOMICS

Microtubules Contribute to Tubule Elongation and Anchoring of Endoplasmic Reticulum, Resulting in High Network Complexity in Arabidopsis

(2014) T. Hamada et al.   PLANT PHYSIOLOGY

Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms

(2013) John K. Fink   ACTA NEUROPATHOLOGICA

Arl6IP1 has the ability to shape the mammalian ER membrane in a reticulon-like fashion

(2013) Yasunori Yamamoto et al.   BIOCHEMICAL JOURNAL

A spastic paraplegia mouse model reveals REEP1-dependent ER shaping

(2013) Christian Beetz et al.   JOURNAL OF CLINICAL INVESTIGATION

A Conserved Role for Atlastin GTPases in Regulating Lipid Droplet Size

(2013) Robin W. Klemm et al.   Cell Reports

Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice

(2012) C. Fassier et al.   Disease Models & Mechanisms

Alleviation of seipinopathy-related ER stress by triglyceride storage

(2012) M. Holtta-Vuori et al.   HUMAN MOLECULAR GENETICS

Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12

(2012) Gladys Montenegro et al.   JOURNAL OF CLINICAL INVESTIGATION

Alternative Splicing of Spg7, a Gene Involved in Hereditary Spastic Paraplegia, Encodes a Variant of Paraplegin Targeted to the Endoplasmic Reticulum

(2012) Giuseppe Mancuso et al.   PLoS One

Lipid Droplet De Novo Formation and Fission Are Linked to the Cell Cycle in Fission Yeast

(2012) Allan P. Long et al.   TRAFFIC

The AAA ATPase spastin links microtubule severing to membrane modelling

(2011) Jennifer H. Lumb et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

(2011) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

Embryonic Senescence and Laminopathies in a Progeroid Zebrafish Model

(2011) Eriko Koshimizu et al.   PLoS One

Membrane fusion by the GTPase atlastin requires a conserved C-terminal cytoplasmic tail and dimerization through the middle domain

(2011) T. J. Moss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactomic study on interaction between lipid droplets and mitochondria

(2011) Jing Pu et al.   Protein & Cell

Cold exposure reveals two populations of microtubules in pulmonary endothelia

(2010) Cristhiaan D. Ochoa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia

(2010) R. Butler et al.   Disease Models & Mechanisms

Evaluation of loss of function as an explanation for SPG4-based hereditary spastic paraplegia

(2010) J. M. Solowska et al.   HUMAN MOLECULAR GENETICS

Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network

(2010) Seong H. Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Drosophila Atlastin regulates the stability of muscle microtubules and is required for synapse development

(2009) Mihye Lee et al.   DEVELOPMENTAL BIOLOGY

Conserved aromatic and basic amino acid residues in the pore region ofCaenorhabditis elegansspastin play critical roles in microtubule severing

(2009) Yuka Matsushita-Ishiodori et al.   GENES TO CELLS

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover

(2009) Scott W. Eastman et al.   JOURNAL OF CELL BIOLOGY

Role of kinesin-1 and cytoplasmic dynein in endoplasmic reticulum movement in VERO cells

(2009) M. J. Wozniak et al.   JOURNAL OF CELL SCIENCE

Pleiotropic effects of spastin on neurite growth depending on expression levels

(2009) Elena Riano et al.   JOURNAL OF NEUROCHEMISTRY

Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients

(2009) Paul R. Kasher et al.   JOURNAL OF NEUROCHEMISTRY

Expansion of mutation spectrum, determination of mutation cluster regions and predictive structural classification of SPAST mutations in hereditary spastic paraplegia

(2008) Moneef Shoukier et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Quantitative and Functional Analyses of Spastin in the Nervous System: Implications for Hereditary Spastic Paraplegia

(2008) J. M. Solowska et al.   JOURNAL OF NEUROSCIENCE