Journal
JOURNAL OF CELL SCIENCE
Volume 127, Issue 15, Pages 3227-3232Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.147447
Keywords
RHD3; Arabidopsis; Unfolded protein response; IRE1
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Funding
- Chemical Sciences, Geosciences and Biosciences Division, Office of Basic Energy Sciences, Office of Science, US Department of Energy [DE-FG02-91ER20021]
- National Institutes of Health [R01 GM101038]
- National Science Foundation [MCB 1243792]
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Whether structure and function are correlated features of organelles is a fundamental question in cell biology. Here, we have assessed the ability of Arabidopsis mutants with a defective endoplasmic reticulum (ER) structure to invoke the unfolded protein response (UPR), an essential ER signaling pathway. Through molecular and genetic approaches, we show that loss of the ER-shaping GTPase Root Hair Defective 3 (RHD3) specifically disrupts the UPR by interfering with the mRNA splicing function of the master regulator IRE1. These findings establish a new role for RHD3 in the ER and support specificity of the effects of ER-shaping mutations on ER function.
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