Denaturing and Native Mass Spectrometric Analytics for Biotherapeutic Drug Discovery Research: Historical, Current, and Future Personal Perspectives
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Denaturing and Native Mass Spectrometric Analytics for Biotherapeutic Drug Discovery Research: Historical, Current, and Future Personal Perspectives
Authors
Keywords
-
Journal
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Volume -, Issue -, Pages -
Publisher
American Chemical Society (ACS)
Online
2021-04-23
DOI
10.1021/jasms.1c00036
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Rational selection of building blocks for the assembly of bispecific antibodies
- (2021) Danyang Gong et al. mAbs
- Heterogeneity of Glycan Processing on Trimeric SARS-CoV-2 Spike Protein Revealed by Charge Detection Mass Spectrometry
- (2021) Lohra M. Miller et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Intact Protein Mass Spectrometry of Cell Culture Harvest Guides Cell Line Development for Trispecific Antibodies
- (2020) Fateme Tousi et al. ANALYTICAL CHEMISTRY
- In-depth analysis of monoclonal antibodies using microfluidic capillary electrophoresis and native mass spectrometry
- (2020) Sara Carillo et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Effect of difluoroacetic acid and biological matrices on the development of a liquid chromatography–triple quadrupole mass spectrometry method for determination of intact growth factor proteins
- (2020) Katarína Maráková et al. JOURNAL OF SEPARATION SCIENCE
- Multiplexed mass spectrometry of individual ions improves measurement of proteoforms and their complexes
- (2020) Jared O. Kafader et al. NATURE METHODS
- Rapid online buffer exchange for screening of proteins, protein complexes and cell lysates by native mass spectrometry
- (2020) Zachary L. VanAernum et al. Nature Protocols
- High Mass Analysis with a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: From Inorganic Salt Clusters to Antibody Conjugates and Beyond
- (2020) Iain D. G. Campuzano et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Multispecific drugs herald a new era of biopharmaceutical innovation
- (2020) Raymond J. Deshaies NATURE
- Combining native and ‘omics’ mass spectrometry to identify endogenous ligands bound to membrane proteins
- (2020) Joseph Gault et al. NATURE METHODS
- Resolving heterogeneous macromolecular assemblies by Orbitrap-based single-particle charge detection mass spectrometry
- (2020) Tobias P. Wörner et al. NATURE METHODS
- High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry
- (2020) William S. Sawyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Site-specific glycan analysis of the SARS-CoV-2 spike
- (2020) Yasunori Watanabe et al. SCIENCE
- The Utility of Native MS for Understanding the Mechanism of Action of Repurposed Therapeutics in COVID-19: Heparin as a Disruptor of the SARS-CoV-2 Interaction with Its Host Cell Receptor
- (2020) Yang Yang et al. ANALYTICAL CHEMISTRY
- Discovery of Potent Charge-Reducing Molecules for Native Ion Mobility Mass Spectrometry Studies
- (2020) Jixing Lyu et al. ANALYTICAL CHEMISTRY
- Ultrahigh-Throughput ESI-MS: Sampling pushed to six Samples per Second by Acoustic Ejection Mass Spectrometry
- (2020) Tim Häbe et al. ANALYTICAL CHEMISTRY
- Inter-laboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry
- (2020) Kristina Srzentic et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Advances in oligonucleotide drug delivery
- (2020) Thomas C. Roberts et al. NATURE REVIEWS DRUG DISCOVERY
- Advancing Mass Spectrometry Technology in cGMP Environments
- (2020) Da Ren TRENDS IN BIOTECHNOLOGY
- Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy
- (2020) Rebecca Beveridge et al. ACS Central Science
- Intact and subunit-specific analysis of bispecific antibodies by sheathless CE-MS
- (2020) Christoph Gstöttner et al. ANALYTICA CHIMICA ACTA
- Bispecific antibodies targeting dual tumor-associated antigens in cancer therapy
- (2020) Shuyu Huang et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- SARS-CoV-2 vaccines in development
- (2020) Florian Krammer NATURE
- COVID-19 antibodies on trial
- (2020) Laura DeFrancesco NATURE BIOTECHNOLOGY
- Antibody–Drug Conjugates: The Last Decade
- (2020) Nicolas Joubert et al. Pharmaceuticals
- Use of Ultra-short Columns for Therapeutic Protein Separations, Part 2: Designing the Optimal Column Dimension for Reversed-Phase Liquid Chromatography
- (2020) Szabolcs Fekete et al. ANALYTICAL CHEMISTRY
- Use of Ultrashort Columns for Therapeutic Protein Separations. Part 1: Theoretical Considerations and Proof of Concept
- (2020) Szabolcs Fekete et al. ANALYTICAL CHEMISTRY
- Purification of guanine-quadruplex using monolithic stationary phase under ion-exchange conditions
- (2020) Artaches A. Kazarian et al. JOURNAL OF CHROMATOGRAPHY A
- Pushing the limits of native MS: Online SEC-native MS for structural biology applications
- (2020) Evolène Deslignière et al. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
- Quantification of siRNA-Antibody Conjugates in Biological Matrices by Triplex-Forming Oligonucleotide ELISA
- (2019) Sara C. Humphreys et al. Nucleic Acid Therapeutics
- In-solution enrichment identifies peptide inhibitors of protein–protein interactions
- (2019) Fayçal Touti et al. Nature Chemical Biology
- Recommendations for reporting ion mobility Mass Spectrometry measurements
- (2019) Valérie Gabelica et al. MASS SPECTROMETRY REVIEWS
- The impact of standard accelerated stability conditions on antibody higher order structure as assessed by mass spectrometry
- (2019) Richard A. Kerr et al. mAbs
- Acoustic Mist Ionization Platform for Direct and Contactless Ultrahigh-Throughput Mass Spectrometry Analysis of Liquid Samples
- (2019) Ian Sinclair et al. ANALYTICAL CHEMISTRY
- Simple Approach for Improved LC–MS Analysis of Protein Biopharmaceuticals via Modification of Desolvation Gas
- (2019) Shunhai Wang et al. ANALYTICAL CHEMISTRY
- Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics
- (2019) Sokullu et al. Pharmaceutics
- Native and Denaturing MS Protein Deconvolution for Biopharma: Monoclonal Antibodies and Antibody–Drug Conjugates to Polydisperse Membrane Proteins and Beyond
- (2019) Iain D. G. Campuzano et al. ANALYTICAL CHEMISTRY
- Elucidating heavy/light chain pairing preferences to facilitate the assembly of bispecific IgG in single cells
- (2019) Kamal Kishore Joshi et al. mAbs
- Best practices and benchmarks for intact protein analysis for top-down mass spectrometry
- (2019) Daniel P. Donnelly et al. NATURE METHODS
- Bispecific antibodies: a mechanistic review of the pipeline
- (2019) Aran F. Labrijn et al. NATURE REVIEWS DRUG DISCOVERY
- Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye
- (2019) Whitney Shatz et al. PLoS One
- Conceptual Approaches to Modulating Antibody Effector Functions and Circulation Half-Life
- (2019) Kevin O. Saunders Frontiers in Immunology
- Historical, Current and Future Developments of Traveling Wave Ion Mobility Mass Spectrometry: A Personal Perspective
- (2019) Iain D.G. Campuzano et al. TRAC-TRENDS IN ANALYTICAL CHEMISTRY
- Proton Transfer Charge Reduction Enables High-Throughput Top-Down Analysis of Large Proteoforms
- (2019) Romain Huguet et al. ANALYTICAL CHEMISTRY
- Native Hydrophobic Interaction Chromatography Hyphenated to Mass Spectrometry for Characterization of Monoclonal Antibody Minor Variants
- (2019) Bingchuan Wei et al. ANALYTICAL CHEMISTRY
- PROTACs as Potential Therapeutic Agents for Cancer Drug Resistance
- (2019) Xiuyun Sun et al. BIOCHEMISTRY
- Direct measurement of light and heavy antibody chains using ion mobility and middle-down mass spectrometry
- (2019) Rafael D. Melani et al. mAbs
- The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
- (2019) Jude Canon et al. NATURE
- Enhanced Sequence Coverage of Large Proteins by Combining Ultraviolet Photodissociation with Proton Transfer Reactions
- (2019) James D. Sanders et al. ANALYTICAL CHEMISTRY
- Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors
- (2019) Brian A. Lanman et al. JOURNAL OF MEDICINAL CHEMISTRY
- Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes
- (2018) Kyle L. Fort et al. ANALYST
- Improving Mass Spectral Quality of Monoclonal Antibody Middle-Up LC-MS Analysis by Shifting the Protein Charge State Distribution
- (2018) Wei Ding et al. ANALYTICAL CHEMISTRY
- An Online Four-Dimensional HIC×SEC-IM×MS Methodology for Proof-of-Concept Characterization of Antibody Drug Conjugates
- (2018) Anthony Ehkirch et al. ANALYTICAL CHEMISTRY
- Crosstalk between phosphorylation and O-GlcNAcylation: friend or foe
- (2018) Saar A. M. van der Laarse et al. FEBS Journal
- Where Do Recent Small Molecule Clinical Development Candidates Come From?
- (2018) Dean G. Brown et al. JOURNAL OF MEDICINAL CHEMISTRY
- Parsimonious Charge Deconvolution for Native Mass Spectrometry
- (2018) Marshall Bern et al. JOURNAL OF PROTEOME RESEARCH
- Investigation of Sequence Clipping and Structural Heterogeneity of an HIV Broadly Neutralizing Antibody by a Comprehensive LC-MS Analysis
- (2018) Vera B. Ivleva et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Native mass spectrometry combined with enzymatic dissection unravels glycoform heterogeneity of biopharmaceuticals
- (2018) Therese Wohlschlager et al. Nature Communications
- Membrane protein structural biology in the era of single particle cryo-EM
- (2018) Yifan Cheng CURRENT OPINION IN STRUCTURAL BIOLOGY
- A systematic approach for analysis and characterization of mispairing in bispecific antibodies with asymmetric architecture
- (2018) Chunlei Wang et al. mAbs
- Discovery, characterization, and remediation of a C-terminal Fc-extension in proteins expressed in CHO cells
- (2018) Christopher S. Spahr et al. mAbs
- Direct quality control of glycoengineered erythropoietin variants
- (2018) Tomislav Čaval et al. Nature Communications
- Rapid LC–MS Method for Accurate Molecular Weight Determination of Membrane and Hydrophobic Proteins
- (2018) Jennifer L. Lippens et al. ANALYTICAL CHEMISTRY
- A Novel Online Four-Dimensional SEC×SEC-IM×MS Methodology for Characterization of Monoclonal Antibody Size Variants
- (2018) Anthony Ehkirch et al. ANALYTICAL CHEMISTRY
- Quantitative Determination of Protein–Ligand Affinity by Size Exclusion Chromatography Directly Coupled to High-Resolution Native Mass Spectrometry
- (2018) Chengfeng Ren et al. ANALYTICAL CHEMISTRY
- Charge variant native mass spectrometry benefits mass precision and dynamic range of monoclonal antibody intact mass analysis
- (2018) Aaron O. Bailey et al. mAbs
- Comprehensive characterisation of the heterogeneity of adalimumab via charge variant analysis hyphenated on-line to native high resolution Orbitrap mass spectrometry
- (2018) Florian Füssl et al. mAbs
- Expression vector-derived heterogeneity in a therapeutic IgG4 monoclonal antibody
- (2018) Douglas S. Rehder et al. mAbs
- Charge variants characterization of a monoclonal antibody by ion exchange chromatography coupled on-line to native mass spectrometry: Case study after a long-term storage at +5 °C
- (2017) Y. Leblanc et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Fourier Transform-Ion Cyclotron Resonance Mass Spectrometry as a Platform for Characterizing Multimeric Membrane Protein Complexes
- (2017) Jennifer L. Lippens et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Submicrometer Emitter ESI Tips for Native Mass Spectrometry of Membrane Proteins in Ionic and Nonionic Detergents
- (2017) Anna C. Susa et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- High-resolution mass spectrometry confirms the presence of a hydroxyproline (Hyp) post-translational modification in the GGGGP linker of an Fc-fusion protein
- (2017) Chris Spahr et al. mAbs
- Identification of small molecules using accurate mass MS/MS search
- (2017) Tobias Kind et al. MASS SPECTROMETRY REVIEWS
- Strategies and challenges for the next generation of antibody–drug conjugates
- (2017) Alain Beck et al. NATURE REVIEWS DRUG DISCOVERY
- Biophysical properties of the clinical-stage antibody landscape
- (2017) Tushar Jain et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of Small-Molecule Noncovalent Binders Utilizing SAMDI Technology
- (2017) Erica C. VanderPorten et al. SLAS Discovery
- Rapid quantitation of monoclonal antibody N-glyco-occupancy and afucosylation using mass spectrometry
- (2016) Suli Liu et al. ANALYTICAL BIOCHEMISTRY
- Recent applications of light scattering measurement in the biological and biopharmaceutical sciences
- (2016) Allen P. Minton ANALYTICAL BIOCHEMISTRY
- Characterization of Cysteinylation and Trisulfide Bonds in a Recombinant Monoclonal Antibody
- (2016) Adriana Kita et al. ANALYTICAL CHEMISTRY
- Characterization of Chain Pairing Variants of Bispecific IgG Expressed in a Single Host Cell by High-Resolution Native and Denaturing Mass Spectrometry
- (2016) Luis Schachner et al. ANALYTICAL CHEMISTRY
- Fourier Analysis Method for Analyzing Highly Congested Mass Spectra of Ion Populations with Repeated Subunits
- (2016) Sean P. Cleary et al. ANALYTICAL CHEMISTRY
- Native MS Analysis of Bacteriorhodopsin and an Empty Nanodisc by Orthogonal Acceleration Time-of-Flight, Orbitrap and Ion Cyclotron Resonance
- (2016) Iain D. G. Campuzano et al. ANALYTICAL CHEMISTRY
- Characterization and Higher-Order Structure Assessment of an Interchain Cysteine-Based ADC: Impact of Drug Loading and Distribution on the Mechanism of Aggregation
- (2016) Jianxin Guo et al. BIOCONJUGATE CHEMISTRY
- Determination of critical quality attributes for monoclonal antibodies using quality by design principles
- (2016) Nadja Alt et al. BIOLOGICALS
- Antibody-drug conjugates—an emerging class of cancer treatment
- (2016) Nikolaos Diamantis et al. BRITISH JOURNAL OF CANCER
- Engineering an IgG Scaffold Lacking Effector Function with Optimized Developability
- (2016) Frederick W. Jacobsen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Intact mass analysis of monoclonal antibodies by capillary electrophoresis—Mass spectrometry
- (2016) Mei Han et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Analysis of antibody-drug conjugates by comprehensive on-line two-dimensional hydrophobic interaction chromatography x reversed phase liquid chromatography hyphenated to high resolution mass spectrometry. I − Optimization of separation conditions
- (2016) Morgan Sarrut et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Analysis of antibody-drug conjugates by comprehensive on-line two-dimensional hydrophobic interaction chromatography x reversed phase liquid chromatography hyphenated to high resolution mass spectrometry. II- Identification of sub-units for the characterization of even and odd load drug species
- (2016) Morgan Sarrut et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Examining the Heterogeneous Genome Content of Multipartite Viruses BMV and CCMV by Native Mass Spectrometry
- (2016) Michiel van de Waterbeemd et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Development of a Magnetic Microbead Affinity Selection Screen (MagMASS) Using Mass Spectrometry for Ligands to the Retinoid X Receptor-α
- (2016) Michael D. Rush et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Native MS and ECD Characterization of a Fab–Antigen Complex May Facilitate Crystallization for X-ray Diffraction
- (2016) Ying Zhang et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Negative Ions Enhance Survival of Membrane Protein Complexes
- (2016) Idlir Liko et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Native Mass Spectrometry: What is in the Name?
- (2016) Aneika C. Leney et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Cysteinylation of a monoclonal antibody leads to its inactivation
- (2016) Troy McSherry et al. mAbs
- Precise quantification of mixtures of bispecific IgG produced in single host cells by liquid chromatography-Orbitrap high-resolution mass spectrometry
- (2016) Yiyuan Yin et al. mAbs
- Molecular basis of high viscosity in concentrated antibody solutions: Strategies for high concentration drug product development
- (2016) Dheeraj S. Tomar et al. mAbs
- Rapid, semi-automated protein terminal characterization using ISDetect
- (2016) Corey E Bakalarski et al. NATURE BIOTECHNOLOGY
- High-resolution mass spectrometry of small molecules bound to membrane proteins
- (2016) Joseph Gault et al. NATURE METHODS
- Structural Characterization of a Monoclonal Antibody–Maytansinoid Immunoconjugate
- (2015) Quanzhou Luo et al. ANALYTICAL CHEMISTRY
- Deconvolution Method for Specific and Nonspecific Binding of Ligand to Multiprotein Complex by Native Mass Spectrometry
- (2015) Shenheng Guan et al. ANALYTICAL CHEMISTRY
- Bayesian Deconvolution of Mass and Ion Mobility Spectra: From Binary Interactions to Polydisperse Ensembles
- (2015) Michael T. Marty et al. ANALYTICAL CHEMISTRY
- Tandem Native Mass-Spectrometry on Antibody–Drug Conjugates and Submillion Da Antibody–Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector
- (2015) Andrey Dyachenko et al. ANALYTICAL CHEMISTRY
- Characterization of the direct interaction between KcsA-Kv1.3 and its inhibitors
- (2015) Han Xu et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Enhancing the performance of LC-MS for intact protein analysis by counteracting the signal suppression effects of trifluoroacetic acid during electrospray
- (2015) Jin Chen et al. CHEMICAL COMMUNICATIONS
- Surface Plasmon Resonance (SPR) Biosensors in Pharmaceutical Analysis
- (2015) Andreea Olaru et al. CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
- Human cell lines for biopharmaceutical manufacturing: history, status, and future perspectives
- (2015) Jennifer Dumont et al. CRITICAL REVIEWS IN BIOTECHNOLOGY
- Fc glycans of therapeutic antibodies as critical quality attributes
- (2015) Dietmar Reusch et al. GLYCOBIOLOGY
- Improved Peak Detection and Deconvolution of Native Electrospray Mass Spectra from Large Protein Complexes
- (2015) Jonathan Lu et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry
- (2015) Markus Haberger et al. mAbs
- Heavy and light chain pairing of bivalent quadroma and knobs-into-holes antibodies analyzed by UHR-ESI-QTOF mass spectrometry
- (2015) Wolfgang Schaefer et al. mAbs
- Discovery and characterization of hydroxylysine in recombinant monoclonal antibodies
- (2015) Qing Xie et al. mAbs
- Mechanisms of action of therapeutic antibodies for cancer
- (2015) J.M. Redman et al. MOLECULAR IMMUNOLOGY
- ProSight Lite: Graphical software to analyze top-down mass spectrometry data
- (2015) Ryan T. Fellers et al. PROTEOMICS
- Absorption mode Fourier transform mass spectrometry with no baseline correction using a novel asymmetric apodization function
- (2015) David P. A. Kilgour et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- Therapeutic antibodies: their mechanisms of action and the pathological findings they induce in toxicity studies
- (2015) Masami Suzuki et al. Journal of Toxicologic Pathology
- Statistical Modeling of the Drug Load Distribution on Trastuzumab Emtansine (Kadcyla), a Lysine-Linked Antibody Drug Conjugate
- (2014) Michael T. Kim et al. BIOCONJUGATE CHEMISTRY
- Enhanced Fourier transform for Orbitrap mass spectrometry
- (2014) Oliver Lange et al. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
- What Protein Charging (and Supercharging) Reveal about the Mechanism of Electrospray Ionization
- (2014) Rachel R. Ogorzalek Loo et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Separation of mAbs molecular variants by analytical hydrophobic interaction chromatography HPLC: overview and applications
- (2014) Mark Haverick et al. mAbs
- Assessment of chemical modifications of sites in the CDRs of recombinant antibodies
- (2014) Markus Haberger et al. mAbs
- Membrane proteins bind lipids selectively to modulate their structure and function
- (2014) Arthur Laganowsky et al. NATURE
- Determination of Protein–Ligand Binding Constants of a Cooperatively Regulated Tetrameric Enzyme Using Electrospray Mass Spectrometry
- (2013) Dragana Cubrilovic et al. ACS Chemical Biology
- Effects of Polarity on the Structures and Charge States of Native-Like Proteins and Protein Complexes in the Gas Phase
- (2013) Samuel J. Allen et al. ANALYTICAL CHEMISTRY
- From Protein Complexes to Subunit Backbone Fragments: A Multi-stage Approach to Native Mass Spectrometry
- (2013) Mikhail E. Belov et al. ANALYTICAL CHEMISTRY
- Top-Down Structural Analysis of an Intact Monoclonal Antibody by Electron Capture Dissociation-Fourier Transform Ion Cyclotron Resonance-Mass Spectrometry
- (2013) Yuan Mao et al. ANALYTICAL CHEMISTRY
- Development of a Native Nanoelectrospray Mass Spectrometry Method for Determination of the Drug-to-Antibody Ratio of Antibody–Drug Conjugates
- (2013) Jia Chen et al. ANALYTICAL CHEMISTRY
- Ion Mobility Analysis of Molecular Dynamics
- (2013) Thomas Wyttenbach et al. Annual Review of Physical Chemistry
- Separation of intact proteins by using polyhedral oligomeric silsesquioxane based hybrid monolithic capillary columns
- (2013) Zheyi Liu et al. JOURNAL OF CHROMATOGRAPHY A
- Interpretation and Deconvolution of Nanodisc Native Mass Spectra
- (2013) Michael T. Marty et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Site-specific antibody drug conjugates for cancer therapy
- (2013) Siler Panowski et al. mAbs
- In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap
- (2013) Sara Rosati et al. mAbs
- Mass spectrometry of intact membrane protein complexes
- (2013) Arthur Laganowsky et al. Nature Protocols
- Maturing antibody–drug conjugate pipeline hits 30
- (2013) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences
- (2013) Riccardo Torosantucci et al. PHARMACEUTICAL RESEARCH
- Antibody–drug conjugates:
- (2013) Stephen Ornes PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural MS Pulls Its Weight
- (2013) M. Sharon SCIENCE
- Characterization of Therapeutic Antibodies and Related Products
- (2012) Alain Beck et al. ANALYTICAL CHEMISTRY
- Massign: An Assignment Strategy for Maximizing Information from the Mass Spectra of Heterogeneous Protein Assemblies
- (2012) Nina Morgner et al. ANALYTICAL CHEMISTRY
- Native Intact Mass Determination of Antibodies Conjugated with Monomethyl Auristatin E and F at Interchain Cysteine Residues
- (2012) John F. Valliere-Douglass et al. ANALYTICAL CHEMISTRY
- Toward Full Peptide Sequence Coverage by Dual Fragmentation Combining Electron-Transfer and Higher-Energy Collision Dissociation Tandem Mass Spectrometry
- (2012) Christian K. Frese et al. ANALYTICAL CHEMISTRY
- Fc-fusion proteins: new developments and future perspectives
- (2012) Daniel M. Czajkowsky et al. EMBO Molecular Medicine
- Charge detection mass spectrometry for single ions with a limit of detection of 30 charges
- (2012) Nathan C. Contino et al. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
- Charge Detection Mass Spectrometry with Resolved Charge States
- (2012) Nathan C. Contino et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- High-sensitivity Orbitrap mass analysis of intact macromolecular assemblies
- (2012) Rebecca J Rose et al. NATURE METHODS
- Post-translational modification: nature's escape from genetic imprisonment and the basis for dynamic information encoding
- (2012) Sudhakaran Prabakaran et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- Structural Analysis of Intact Monoclonal Antibodies by Electron Transfer Dissociation Mass Spectrometry
- (2011) Yury O. Tsybin et al. ANALYTICAL CHEMISTRY
- Tunable Degradation of Maleimide–Thiol Adducts in Reducing Environments
- (2011) Aaron D. Baldwin et al. BIOCONJUGATE CHEMISTRY
- Mass spectrometry: come of age for structural and dynamical biology
- (2011) Justin LP Benesch et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Automated Protein–Ligand Interaction Screening by Mass Spectrometry
- (2011) Hannah J. Maple et al. JOURNAL OF MEDICINAL CHEMISTRY
- Intact protein analysis in the biopharmaceutical field
- (2011) Aline Staub et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Identification of Amino Acid Residues Responsible for the Release of Free Drug from an Antibody–Drug Conjugate Utilizing Lysine–Succinimidyl Ester Chemistry
- (2011) Hung-Wei Chih et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Phase Correction of Fourier Transform Ion Cyclotron Resonance Mass Spectra Using MatLab
- (2011) Yulin Qi et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Profiling of integral membrane proteins and their post translational modifications using high-resolution mass spectrometry
- (2011) Puneet Souda et al. METHODS
- Ligand-Binding Mass Spectrometry to Study Biotransformation of Fusion Protein Drugs and Guide Immunoassay Development: Strategic Approach and Application to Peptibodies Targeting the Thrombopoietin Receptor
- (2010) Michael P. Hall et al. AAPS Journal
- Recent advances of capillary electrophoresis in pharmaceutical analysis
- (2010) Leena Suntornsuk ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Electron transfer dissociation with supplemental activation to differentiate aspartic and isoaspartic residues in doubly charged peptide cations
- (2010) Wai Yi Kelly Chan et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Cell culture processes for monoclonal antibody production
- (2010) Feng Li et al. mAbs
- Detection of intact megaDalton protein assemblies of vanillyl-alcohol oxidase by mass spectrometry
- (2010) Willem J. H. Van Berkel et al. PROTEIN SCIENCE
- Identification of Aspartic and Isoaspartic Acid Residues in Amyloid β Peptides, Including Aβ1−42, Using Electron−Ion Reactions
- (2009) Nadezda P. Sargaeva et al. ANALYTICAL CHEMISTRY
- Ultraviolet Photodissociation: Developments towards Applications for Mass-Spectrometry-Based Proteomics
- (2009) Tony Ly et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Mass spectrometry in the analysis of N-linked and O-linked glycans
- (2009) Simon J North et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Computational analysis of membrane proteins: the largest class of drug targets
- (2009) Yalini Arinaminpathy et al. DRUG DISCOVERY TODAY
- Residual counter ions can stabilise a large protein complex in the gas phase
- (2009) Joanna Freeke et al. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
- Structural characterization of intact antibodies by high-resolution LTQ Orbitrap mass spectrometry
- (2009) Jennifer Zhang et al. JOURNAL OF MASS SPECTROMETRY
- Analysis of reduced monoclonal antibodies using size exclusion chromatography coupled with mass spectrometry
- (2009) Hongcheng Liu et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- MALDI produced ions inspected with a linear ion trap-orbitrap hybrid mass analyzer
- (2009) Kerstin Strupat et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Mass measurement and top-down HPLC/MS analysis of intact monoclonal antibodies on a hybrid linear quadrupole ion trap-orbitrap mass spectrometer
- (2009) Pavel V. Bondarenko et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- Electrospray ionization quadrupole ion-mobility time-of-flight mass spectrometry as a tool to distinguish the lot-to-lot heterogeneity in N-glycosylation profile of the therapeutic monoclonal antibody trastuzumab
- (2009) Carola W. N. Damen et al. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
- A general protocol for the crystallization of membrane proteins for X-ray structural investigation
- (2009) Zachary E R Newby et al. Nature Protocols
- The HER-2 Receptor and Breast Cancer: Ten Years of Targeted Anti-HER-2 Therapy and Personalized Medicine
- (2009) J. S. Ross et al. ONCOLOGIST
- Mass Spectrometry of Self-Assembled Monolayers: A New Tool for Molecular Surface Science
- (2008) Milan Mrksich ACS Nano
- Top-down N-terminal sequencing of Immunoglobulin subunits with electrospray ionization time of flight mass spectrometry
- (2008) Da Ren et al. ANALYTICAL BIOCHEMISTRY
- Gas-Phase Proton-Transfer Chemistry Coupled with TOF Mass Spectrometry and Ion Mobility-MS for the Facile Analysis of Poly(ethylene glycols) and PEGylated Polypeptide Conjugates
- (2008) Dhanashri Bagal et al. ANALYTICAL CHEMISTRY
- Stability and Shape of Hepatitis B Virus Capsids In Vacuo
- (2008) Charlotte Uetrecht et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Biomolecule Analysis by Ion Mobility Spectrometry
- (2008) Brian C. Bohrer et al. Annual Review of Analytical Chemistry
- A rapid, sensitive and economical assessment of monoclonal antibody conformational stability by intrinsic tryptophan fluorescence spectroscopy
- (2008) Patrick Garidel et al. Biotechnology Journal
- Terminal sugars of Fc glycans influence antibody effector functions of IgGs
- (2008) T Shantha Raju CURRENT OPINION IN IMMUNOLOGY
- Structural and Functional Characterization of Disulfide Isoforms of the Human IgG2 Subclass
- (2008) Thomas M. Dillon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ion mobility-mass spectrometry
- (2008) Abu B. Kanu et al. JOURNAL OF MASS SPECTROMETRY
- Ion mobility–mass spectrometry analysis of large protein complexes
- (2008) Brandon T Ruotolo et al. Nature Protocols
- Determination of N-glycosylation sites and site heterogeneity in a monoclonal antibody by electrospray quadrupole ion-mobility time-of-flight mass spectrometry
- (2007) Petra Olivova et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started