Analysis of antibody-drug conjugates by comprehensive on-line two-dimensional hydrophobic interaction chromatography x reversed phase liquid chromatography hyphenated to high resolution mass spectrometry. II- Identification of sub-units for the characterization of even and odd load drug species

Title

Analysis of antibody-drug conjugates by comprehensive on-line two-dimensional hydrophobic interaction chromatography x reversed phase liquid chromatography hyphenated to high resolution mass spectrometry. II- Identification of sub-units for the characterization of even and odd load drug species

Authors

Keywords

On-line comprehensive 2DLC, HICxRPLC-QTOF-MS, Quadrupole time-of-flight, Antibody-drug conjugate, ADCs, Odd DARs

Journal

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Volume 1032, Issue -, Pages 91-102

Publisher

Elsevier BV

Online

2016-06-29

DOI

10.1016/j.jchromb.2016.06.049