Charge variant native mass spectrometry benefits mass precision and dynamic range of monoclonal antibody intact mass analysis

Charge Variant Analysis of Monoclonal Antibodies Using Direct Coupled pH Gradient Cation Exchange Chromatography to High-Resolution Native Mass Spectrometry

(2018) Florian Füssl et al.   ANALYTICAL CHEMISTRY

Analysis of Proteins, Protein Complexes, and Organellar Proteomes Using Sheathless Capillary Zone Electrophoresis - Native Mass Spectrometry

(2017) Arseniy M. Belov et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Addressing a Common Misconception: Ammonium Acetate as Neutral pH “Buffer” for Native Electrospray Mass Spectrometry

(2017) Lars Konermann   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Characterization of Chain Pairing Variants of Bispecific IgG Expressed in a Single Host Cell by High-Resolution Native and Denaturing Mass Spectrometry

(2016) Luis Schachner et al.   ANALYTICAL CHEMISTRY

Online Hydrophobic Interaction Chromatography–Mass Spectrometry for Top-Down Proteomics

(2016) Bifan Chen et al.   ANALYTICAL CHEMISTRY

Native Mass Spectrometry: What is in the Name?

(2016) Aneika C. Leney et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Precise quantification of mixtures of bispecific IgG produced in single host cells by liquid chromatography-Orbitrap high-resolution mass spectrometry

(2016) Yiyuan Yin et al.   mAbs

Characterization of Intact Protein Conjugates and Biopharmaceuticals Using Ion-Exchange Chromatography with Online Detection by Native Electrospray Ionization Mass Spectrometry and Top-Down Tandem Mass Spectrometry

(2015) Khaja Muneeruddin et al.   ANALYTICAL CHEMISTRY

Native mass spectrometry and ion mobility characterization of trastuzumab emtansine, a lysine-linked antibody drug conjugate

(2015) Julien Marcoux et al.   PROTEIN SCIENCE

Characterization of Small Protein Aggregates and Oligomers Using Size Exclusion Chromatography with Online Detection by Native Electrospray Ionization Mass Spectrometry

(2014) Khaja Muneeruddin et al.   ANALYTICAL CHEMISTRY

Innovative Native MS Methodologies for Antibody Drug Conjugate Characterization: High Resolution Native MS and IM-MS for Average DAR and DAR Distribution Assessment

(2014) François Debaene et al.   ANALYTICAL CHEMISTRY

Boundaries of Mass Resolution in Native Mass Spectrometry

(2014) Philip Lössl et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Detailed mass analysis of structural heterogeneity in monoclonal antibodies using native mass spectrometry

(2014) Sara Rosati et al.   Nature Protocols

Complex mixtures of antibodies generated from a single production qualitatively and quantitatively evaluated by native Orbitrap mass spectrometry

(2013) Natalie J Thompson et al.   mAbs

Performing native mass spectrometry analysis on therapeutic antibodies

(2013) Natalie J. Thompson et al.   METHODS

Exploring an Orbitrap Analyzer for the Characterization of Intact Antibodies by Native Mass Spectrometry

(2012) Sara Rosati et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Improving pH gradient cation-exchange chromatography of monoclonal antibodies by controlling ionic strength

(2012) Liangyi Zhang et al.   JOURNAL OF CHROMATOGRAPHY A

Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies

(2012) Yi Du et al.   mAbs

High-sensitivity Orbitrap mass analysis of intact macromolecular assemblies

(2012) Rebecca J Rose et al.   NATURE METHODS

Multiproduct High-Resolution Monoclonal Antibody Charge Variant Separations by pH Gradient Ion-Exchange Chromatography

(2009) Dell Farnan et al.   ANALYTICAL CHEMISTRY

Dynamics of ions of intact proteins in the Orbitrap mass analyzer

(2009) Alexander Makarov et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Heterogeneity of Monoclonal Antibodies Revealed by Charge-Sensitive Methods

(2008) J. Vlasak et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY