Molecular basis of high viscosity in concentrated antibody solutions: Strategies for high concentration drug product development

Aggregate structure, morphology and the effect of aggregation mechanisms on viscosity at elevated protein concentrations

(2015) Gregory V. Barnett et al.   BIOPHYSICAL CHEMISTRY

Critical Examination of the Colloidal Particle Model of Globular Proteins

(2015) Prasad S. Sarangapani et al.   BIOPHYSICAL JOURNAL

The Fallacy of Misplaced Concreteness

(2015) John Prausnitz   BIOPHYSICAL JOURNAL

A multiscale view of therapeutic protein aggregation: A colloid science perspective

(2015) Lucrèce Nicoud et al.   Biotechnology Journal

Calculation of injection forces for highly concentrated protein solutions

(2015) Ingo Fischer et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

SDA 7: A modular and parallel implementation of the simulation of diffusional association software

(2015) Michael Martinez et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Mechanism of Reversible Self-Association of a Monoclonal Antibody: Role of Electrostatic and Hydrophobic Interactions

(2015) Reza Esfandiary et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Computational tool for the early screening of monoclonal antibodies for their viscosities

(2015) Neeraj J Agrawal et al.   mAbs

Rational design of viscosity reducing mutants of a monoclonal antibody: Hydrophobicversuselectrostatic inter-molecular interactions

(2015) Pilarin Nichols et al.   mAbs

Viscosity-Lowering Effect of Amino Acids and Salts on Highly Concentrated Solutions of Two IgG1 Monoclonal Antibodies

(2015) Shujing Wang et al.   MOLECULAR PHARMACEUTICS

2014 FDA drug approvals

(2015) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Innovation in biologic new molecular entities: 1986–2014

(2015) Kathleen L. Miller et al.   NATURE REVIEWS DRUG DISCOVERY

Intermolecular Interactions and the Viscosity of Highly Concentrated Monoclonal Antibody Solutions

(2015) Elaheh Binabaji et al.   PHARMACEUTICAL RESEARCH

Impact of aggregate formation on the viscosity of protein solutions

(2015) Lucrèce Nicoud et al.   Soft Matter

A multiscale view of therapeutic protein aggregation: A colloid science perspective

(2015) Lucrèce Nicoud et al.   Biotechnology Journal

The pH and Concentration Dependence of Protein-Protein Interactions, Conformation, and Viscosity in Crowded Protein Solutions

(2015) Prasad Sarangapani et al.   BIOPHYSICAL JOURNAL

Plasmonic measurements of monoclonal antibody self-association using self-interaction nanoparticle spectroscopy

(2014) Jayapriya Jayaraman et al.   BIOTECHNOLOGY AND BIOENGINEERING

Protein aggregation, particle formation, characterization & rheology

(2014) Samiul Amin et al.   CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

Rheological characterization and injection forces of concentrated protein formulations: An alternative predictive model for non-Newtonian solutions

(2014) Andrea Allmendinger et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Molecular Simulations of the Pairwise Interaction of Monoclonal Antibodies

(2014) Mauro Lapelosa et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Highly Viscous Antibody Solutions Are a Consequence of Network Formation Caused by Domain–Domain Electrostatic Complementarities: Insights from Coarse-Grained Simulations

(2014) Patrick M. Buck et al.   MOLECULAR PHARMACEUTICS

Specific Decrease in Solution Viscosity of Antibodies by Arginine for Therapeutic Formulations

(2014) Naoto Inoue et al.   MOLECULAR PHARMACEUTICS

Concentration Dependent Viscosity of Monoclonal Antibody Solutions: Explaining Experimental Behavior in Terms of Molecular Properties

(2014) Li Li et al.   PHARMACEUTICAL RESEARCH

In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

(2014) Vikas K. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From molecular dynamics to Brownian dynamics

(2014) R. Erban   PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Coarse-Graining Methods for Computational Biology

(2013) Marissa G. Saunders et al.   Annual Review of Biophysics

The Shape of Protein Crowders is a Major Determinant of Protein Diffusion

(2013) Jessica Balbo et al.   BIOPHYSICAL JOURNAL

Do Clustering Monoclonal Antibody Solutions Really Have a Concentration Dependence of Viscosity?

(2013) Jai A. Pathak et al.   BIOPHYSICAL JOURNAL

Perspective on the Martini model

(2013) Siewert J. Marrink et al.   CHEMICAL SOCIETY REVIEWS

Arginine and lysine reduce the high viscosity of serum albumin solutions for pharmaceutical injection

(2013) Naoto Inoue et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Polar Solvents Decrease the Viscosity of High Concentration IgG1 Solutions Through Hydrophobic Solvation and Interaction: Formulation and Biocompatibility Considerations

(2013) Tim J. Kamerzell et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Cosolute Effects on the Chemical Potential and Interactions of an IgG1 Monoclonal Antibody at High Concentrations

(2013) Thomas M. Scherer   JOURNAL OF PHYSICAL CHEMISTRY B

The Role of Amino Acid Sequence in the Self-Association of Therapeutic Monoclonal Antibodies: Insights from Coarse-Grained Modeling

(2013) Anuj Chaudhri et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Monoclonal Antibody Self-Association, Cluster Formation, and Rheology at High Concentrations

(2013) Wayne G. Lilyestrom et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Probing antibody internal dynamics with fluorescence anisotropy and molecular dynamics simulations

(2013) Ekaterine Kortkhonjia et al.   mAbs

Weak Interactions Govern the Viscosity of Concentrated Antibody Solutions: High-Throughput Analysis Using the Diffusion Interaction Parameter

(2012) Brian D. Connolly et al.   BIOPHYSICAL JOURNAL

Coarse-grained molecular simulations of large biomolecules

(2012) Shoji Takada   CURRENT OPINION IN STRUCTURAL BIOLOGY

Comparison of Subcutaneous and Intravenous Administration of Trastuzumab: A Phase I/Ib Trial in Healthy Male Volunteers and Patients With HER2-Positive Breast Cancer

(2012) Chris Wynne et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Proximity energies: a framework for understanding concentrated solutions

(2012) Tom Laue   JOURNAL OF MOLECULAR RECOGNITION

Characterization of protein rheology and delivery forces for combination products

(2012) Nitin Rathore et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Atomic Detail Brownian Dynamics Simulations of Concentrated Protein Solutions with a Mean Field Treatment of Hydrodynamic Interactions

(2012) Paolo Mereghetti et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Coarse-Grained Modeling of the Self-Association of Therapeutic Monoclonal Antibodies

(2012) Anuj Chaudhri et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structure-Activity Relationship for Hydrophobic Salts as Viscosity-Lowering Excipients for Concentrated Solutions of Monoclonal Antibodies

(2012) Zheng Guo et al.   PHARMACEUTICAL RESEARCH

Recombinant human hyaluronidase PH20 (rHuPH20) facilitates subcutaneous infusions of large volumes of immunoglobulin in a swine model

(2012) David W. Kang et al.   Drug Delivery and Translational Research

Coarse-Grained (Multiscale) Simulations in Studies of Biophysical and Chemical Systems

(2011) Shina C.L. Kamerlin et al.   Annual Review of Physical Chemistry

Taking immunogenicity assessment of therapeutic proteins to the next level

(2011) I.C. Büttel et al.   BIOLOGICALS

Development of high concentration protein biopharmaceuticals: The use of platform approaches in formulation development

(2011) Nicholas W. Warne   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Arginine and the Hofmeister Series: The Role of Ion–Ion Interactions in Protein Aggregation Suppression

(2011) Curtiss P. Schneider et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Establishing a Link Between Amino Acid Sequences and Self-Associating and Viscoelastic Behavior of Two Closely Related Monoclonal Antibodies

(2011) Sandeep Yadav et al.   PHARMACEUTICAL RESEARCH

Behavior of Monoclonal Antibodies: Relation Between the Second Virial Coefficient (B 2) at Low Concentrations and Aggregation Propensity and Viscosity at High Concentrations

(2011) Shuntaro Saito et al.   PHARMACEUTICAL RESEARCH

Effect of Sugar Molecules on the Viscosity of High Concentration Monoclonal Antibody Solutions

(2011) Feng He et al.   PHARMACEUTICAL RESEARCH

Construction, MD Simulation, and Hydrodynamic Validation of an All-Atom Model of a Monoclonal IgG Antibody

(2010) J. Paul Brandt et al.   BIOPHYSICAL JOURNAL

Factors Affecting the Viscosity in High Concentration Solutions of Different Monoclonal Antibodies

(2010) Sandeep Yadav et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Predictive tools for stabilization of therapeutic proteins

(2010) Vladimir Voynov et al.   mAbs

Development trends for human monoclonal antibody therapeutics

(2010) Aaron L. Nelson et al.   NATURE REVIEWS DRUG DISCOVERY

Formulation and manufacturability of biologics

(2009) Steven J Shire   CURRENT OPINION IN BIOTECHNOLOGY

Specific interactions in high concentration antibody solutions resulting in high viscosity

(2009) Sandeep Yadav et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Design of therapeutic proteins with enhanced stability

(2009) N. Chennamsetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences

(2008) Huan-Xiang Zhou et al.   Annual Review of Biophysics