Combining native and ‘omics’ mass spectrometry to identify endogenous ligands bound to membrane proteins

Voltage Rollercoaster Filtering of Low-Mass Contaminants During Native Protein Analysis

(2020) John P. McGee et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Collision Induced Unfolding Classifies Ligands Bound to the Integral Membrane Translocator Protein

(2019) Sarah M. Fantin et al.   ANALYTICAL CHEMISTRY

Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors

(2019) Simon R. Foster et al.   CELL

The G protein-coupled receptors deorphanization landscape

(2018) Céline Laschet et al.   BIOCHEMICAL PHARMACOLOGY

Lipid binding attenuates channel closure of the outer membrane protein OmpF

(2018) Idlir Liko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Validation of ligands in macromolecular structures determined by X-ray crystallography

(2018) Oliver S. Smart et al.   Acta Crystallographica Section D-Structural Biology

Membrane curvature allosterically regulates the phosphatidylinositol cycle, controlling its rate and acyl chain composition of its lipid intermediates

(2018) José Carlos Bozelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

(2018) Hsin-Yung Yen et al.   NATURE

Probing the Dissociation of Protein Complexes by Means of Gas-Phase H/D Exchange Mass Spectrometry

(2018) Ulrik H. Mistarz et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

An engineered thermal-shift screen reveals specific lipid preferences of eukaryotic and prokaryotic membrane proteins

(2018) Emmanuel Nji et al.   Nature Communications

The lipid environment of Escherichia coli Aquaporin Z

(2018) Victoria Schmidt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Fourier Transform-Ion Cyclotron Resonance Mass Spectrometry as a Platform for Characterizing Multimeric Membrane Protein Complexes

(2017) Jennifer L. Lippens et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Structural basis of nucleotide sugar transport across the Golgi membrane

(2017) Joanne L. Parker et al.   NATURE

Top-down characterization of endogenous protein complexes with native proteomics

(2017) Owen S Skinner et al.   Nature Chemical Biology

HMDB 4.0: the human metabolome database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Translocator Protein 18 kDa (TSPO): An Old Protein with New Functions?

(2016) Fei Li et al.   BIOCHEMISTRY

Crystal Structure of the Human Cannabinoid Receptor CB 1

(2016) Tian Hua et al.   CELL

Negative Ions Enhance Survival of Membrane Protein Complexes

(2016) Idlir Liko et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Simultaneous Metabolite, Protein, Lipid Extraction (SIMPLEX): A Combinatorial Multimolecular Omics Approach for Systems Biology

(2016) Cristina Coman et al.   MOLECULAR & CELLULAR PROTEOMICS

High-resolution mass spectrometry of small molecules bound to membrane proteins

(2016) Joseph Gault et al.   NATURE METHODS

New supercharging reagents produce highly charged protein ions in native mass spectrometry

(2015) Catherine C. Going et al.   ANALYST

The Role of the Detergent Micelle in Preserving the Structure of Membrane Proteins in the Gas Phase

(2015) Eamonn Reading et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CHARMM-GUI Martini Maker for Coarse-Grained Simulations with the Martini Force Field

(2015) Yifei Qi et al.   Journal of Chemical Theory and Computation

Comment on "Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism"

(2015) J. Wang   SCIENCE

Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism

(2015) F. Li et al.   SCIENCE

Charge Reduction Stabilizes Intact Membrane Protein Complexes for Mass Spectrometry

(2014) Shahid Mehmood et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Membrane proteins bind lipids selectively to modulate their structure and function

(2014) Arthur Laganowsky et al.   NATURE

Structures of bacterial homologues of SWEET transporters in two distinct conformations

(2014) Yan Xu et al.   NATURE

Novel Parallelized Quadrupole/Linear Ion Trap/Orbitrap Tribrid Mass Spectrometer Improving Proteome Coverage and Peptide Identification Rates

(2013) Michael W. Senko et al.   ANALYTICAL CHEMISTRY

Characterization and Modeling of the Oligomeric State and Ligand Binding Behavior of Purified Translocator Protein 18 kDa from Rhodobacter sphaeroides

(2013) Fei Li et al.   BIOCHEMISTRY

Shorthand notation for lipid structures derived from mass spectrometry

(2013) Gerhard Liebisch et al.   JOURNAL OF LIPID RESEARCH

Mass spectrometry of intact membrane protein complexes

(2013) Arthur Laganowsky et al.   Nature Protocols

The Binding of Antibiotics in OmpF Porin

(2012) Brigitte K. Ziervogel et al.   STRUCTURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Directed epitope delivery across the Escherichia coli outer membrane through the porin OmpF

(2010) N. G. Housden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

electronic Ligand Builder and Optimization Workbench(eLBOW): a tool for ligand coordinate and restraint generation

(2009) Nigel W. Moriarty et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Development and crystallization of a minimal thermostabilised G protein-coupled receptor

(2009) Tony Warne et al.   PROTEIN EXPRESSION AND PURIFICATION