Fc-fusion proteins: new developments and future perspectives

Abnormalities in IgA and IgM are associated with treatment-resistant ITP

(2012) J. E. Arnason et al.   BLOOD

Detection of weak receptor-ligand interactions using IgM and J-chain-based fusion proteins

(2012) Johannes U. Ammann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1

(2012) Inessa Schwab et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Natural IgM in Immune Equilibrium and Harnessing Their Therapeutic Potential

(2012) S. V. Kaveri et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Human FcRL4 and FcRL5 Are Receptors for IgA and IgG

(2012) T. J. Wilson et al.   JOURNAL OF IMMUNOLOGY

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

(2012) Barton F. Haynes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mouse model recapitulating human Fc  receptor structural and functional diversity

(2012) P. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A secreted protein microarray platform for extracellular protein interaction discovery

(2011) Sree R. Ramani et al.   ANALYTICAL BIOCHEMISTRY

Intracellular antibody-mediated immunity and the role of TRIM21

(2011) William A. McEwan et al.   BIOESSAYS

Rituximab infusion induces NK activation in lymphoma patients with the high-affinity CD16 polymorphism

(2011) S. Veeramani et al.   BLOOD

The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP119)

(2011) Jianguo Shi et al.   BMC BIOTECHNOLOGY

Non-immunoglobulin based protein scaffolds

(2011) John Löfblom et al.   CURRENT OPINION IN BIOTECHNOLOGY

Strategies for extended serum half-life of protein therapeutics

(2011) Roland E Kontermann   CURRENT OPINION IN BIOTECHNOLOGY

Polymer–drug conjugates as nano-sized medicines

(2011) Fabiana Canal et al.   CURRENT OPINION IN BIOTECHNOLOGY

CD22 serves as a receptor for soluble IgM

(2011) Takahiro Adachi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Introduction to current and future protein therapeutics: A protein engineering perspective

(2011) Paul J. Carter   EXPERIMENTAL CELL RESEARCH

Monocyte Subsets Responsible for Immunoglobulin G-Dependent Effector Functions In Vivo

(2011) Markus Biburger et al.   IMMUNITY

TNF receptor II fusion protein with tandemly repeated Fc domains

(2011) H. Nagashima et al.   JOURNAL OF BIOCHEMISTRY

Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors

(2011) Lela Kardava et al.   JOURNAL OF CLINICAL INVESTIGATION

TOSO, the Fcμ Receptor, Is Highly Expressed on Chronic Lymphocytic Leukemia B Cells, Internalizes upon IgM Binding, Shuttles to the Lysosome, and Is Downregulated in Response to TLR Activation

(2011) Bérengère Vire et al.   JOURNAL OF IMMUNOLOGY

An Antitumor Cellular Vaccine Based on a Mini-Membrane IgE

(2011) E. A. Nigro et al.   JOURNAL OF IMMUNOLOGY

Targeting Fc RI on Polymorphonuclear Cells Induces Tumor Cell Killing through Autophagy

(2011) J. E. Bakema et al.   JOURNAL OF IMMUNOLOGY

Recombinant Dimeric IgA Antibodies against the Epidermal Growth Factor Receptor Mediate Effective Tumor Cell Killing

(2011) S. Lohse et al.   JOURNAL OF IMMUNOLOGY

A Novel Human IgA Monoclonal Antibody Protects against Tuberculosis

(2011) S. Balu et al.   JOURNAL OF IMMUNOLOGY

Single-Chain Fv-Based Anti-HIV Proteins: Potential and Limitations

(2011) A. P. West et al.   JOURNAL OF VIROLOGY

A Neonatal Fc Receptor-Targeted Mucosal Vaccine Strategy Effectively Induces HIV-1 Antigen-Specific Immunity to Genital Infection

(2011) L. Lu et al.   JOURNAL OF VIROLOGY

Immunoglobulin A

(2011) Jantine E. Bakema et al.   mAbs

Therapeutic Fc-fusion proteins and peptides as successful alternatives to antibodies

(2011) Alain Beck et al.   mAbs

Antibody-based therapeutics to watch in 2011

(2011) Janice M. Reichert   mAbs

Mannose-Functionalized “Pathogen-like” Polyanhydride Nanoparticles Target C-Type Lectin Receptors on Dendritic Cells

(2011) Brenda Carrillo-Conde et al.   MOLECULAR PHARMACEUTICS

The human immunoglobulin A Fc receptor FcαRI: a multifaceted regulator of mucosal immunity

(2011) J E Bakema et al.   Mucosal Immunology

Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway

(2011) Robert M. Anthony et al.   NATURE

Efficient mucosal vaccination mediated by the neonatal Fc receptor

(2011) Lilin Ye et al.   NATURE BIOTECHNOLOGY

Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells

(2011) K. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic assessment of SEED: a new engineered antibody platform designed to generate mono- and bispecific antibodies

(2011) M. Muda et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Inhibitory Fc  Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 Antibodies

(2011) F. Li et al.   SCIENCE

Inhibitory ITAM Signaling Traps Activating Receptors with the Phosphatase SHP-1 to Form Polarized "Inhibisome" Clusters

(2011) S. Pfirsch-Maisonnas et al.   Science Signaling

Do regulatory antibodies offer an alternative mechanism to explain the hygiene hypothesis?

(2011) David N.A. Mekhaiel et al.   TRENDS IN PARASITOLOGY

Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential

(2011) Nigel M. Stapleton et al.   Nature Communications

Polymeric human Fc-fusion proteins with modified effector functions

(2011) David N. A. Mekhaiel et al.   Scientific Reports

IVIg modulates BCR signaling through CD22 and promotes apoptosis in mature human B lymphocytes

(2010) J.-F. Seite et al.   BLOOD

Fusion Partners as a Tool for the Expression of Difficult Proteins in Mammalian Cells

(2010) Jue Zhang et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

FCRLA is a resident endoplasmic reticulum protein that associates with intracellular Igs, IgM, IgG and IgA

(2010) T. Santiago et al.   INTERNATIONAL IMMUNOLOGY

Conserved natural IgM antibodies mediate innate and adaptive immunity against the opportunistic fungusPneumocystis murina

(2010) Rekha R. Rapaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fc Receptor-Like A Associates with Intracellular IgG and IgM but Is Dispensable for Antigen-Specific Immune Responses

(2010) T. J. Wilson et al.   JOURNAL OF IMMUNOLOGY

Neonatal FcR Overexpression Boosts Humoral Immune Response in Transgenic Mice

(2010) J. Cervenak et al.   JOURNAL OF IMMUNOLOGY

Importance of Neonatal FcR in Regulating the Serum Half-Life of Therapeutic Proteins Containing the Fc Domain of Human IgG1: A Comparative Study of the Affinity of Monoclonal Antibodies and Fc-Fusion Proteins to Human Neonatal FcR

(2010) Takuo Suzuki et al.   JOURNAL OF IMMUNOLOGY

IgM, Fc Rs, and Malarial Immune Evasion

(2010) D. M. Czajkowsky et al.   JOURNAL OF IMMUNOLOGY

Antibody fragments

(2010) Aaron L. Nelson   mAbs

Enhanced antibody half-life improves in vivo activity

(2010) Jonathan Zalevsky et al.   NATURE BIOTECHNOLOGY

Novel GLP-1 Fusion Chimera as Potent Long Acting GLP-1 Receptor Agonist

(2010) Qinghua Wang et al.   PLoS One

SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies†

(2010) Jonathan H. Davis et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Transmembrane TNF- : structure, function and interaction with anti-TNF agents

(2010) T. Horiuchi et al.   RHEUMATOLOGY

Rituximab: Mechanism of Action

(2010) George J. Weiner   SEMINARS IN HEMATOLOGY

Unmet needs in modern vaccinology

(2010) Geert Leroux-Roels   VACCINE

Hexavalent bispecific antibodies represent a new class of anticancer therapeutics: 1. Properties of anti-CD20/CD22 antibodies in lymphoma

(2009) E. A. Rossi et al.   BLOOD

Discovery and development of biopharmaceuticals: current issues

(2009) William R Strohl et al.   CURRENT OPINION IN BIOTECHNOLOGY

Receptor-Fc fusion therapeutics, traps, and MIMETIBODY™ technology

(2009) Chichi Huang   CURRENT OPINION IN BIOTECHNOLOGY

Optimization of Fc-mediated effector functions of monoclonal antibodies

(2009) William R Strohl   CURRENT OPINION IN BIOTECHNOLOGY

Profiling Carbohydrate-Receptor Interaction with Recombinant Innate Immunity Receptor-Fc Fusion Proteins

(2009) Tsui-Ling Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineering Human IgG1 Affinity to Human Neonatal Fc Receptor: Impact of Affinity Improvement on Pharmacokinetics in Primates

(2009) Y. A. Yeung et al.   JOURNAL OF IMMUNOLOGY

Targeting a Mimotope Vaccine to Activating Fc  Receptors Empowers Dendritic Cells to Prime Specific CD8+ T Cell Responses in Tumor-Bearing Mice

(2009) M. Gil et al.   JOURNAL OF IMMUNOLOGY

Signal initiation in biological systems: the properties and detection of transient extracellular protein interactions

(2009) Gavin J. Wright   Molecular BioSystems

Development trends for therapeutic antibody fragments

(2009) Aaron L Nelson et al.   NATURE BIOTECHNOLOGY

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Toll-Like Receptor 4 Decoy, TOY, Attenuates Gram-Negative Bacterial Sepsis

(2009) Keehoon Jung et al.   PLoS One

Efficacy and safety of rilonacept (interleukin-1 trap) in patients with cryopyrin-associated periodic syndromes: Results from two sequential placebo-controlled studies

(2008) Hal M. Hoffman et al.   ARTHRITIS AND RHEUMATISM

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

Entry of herpesviruses into mammalian cells

(2008) E. E. Heldwein et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Systemic administration of an Fcγ–Fcε-fusion protein in house dust mite sensitive nonhuman primates

(2008) Michael R. Van Scott et al.   CLINICAL IMMUNOLOGY

Effector mechanisms of therapeutic antibodies against ErbB receptors

(2008) Matthias Peipp et al.   CURRENT OPINION IN IMMUNOLOGY

Antigen-specific humoral tolerance or immune augmentation induced by intramuscular delivery of adeno-associated viruses encoding CTLA4-Ig-antigen fusion molecules

(2008) G J Logan et al.   GENE THERAPY

Bifunctional CD22 Ligands Use Multimeric Immunoglobulins as Protein Scaffolds in Assembly of Immune Complexes on B Cells

(2008) Mary K. O’Reilly et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

“Accentuate the negative, eliminate the positive”: Engineering allergy therapeutics to block allergic reactivity through negative signaling

(2007) Andrew Saxon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY