Separation of mAbs molecular variants by analytical hydrophobic interaction chromatography HPLC: overview and applications

Biosimilar monoclonal antibodies: a science-based regulatory challenge

(2013) Paul J Declerck   EXPERT OPINION ON BIOLOGICAL THERAPY

Comparison of the in vitro and in vivo stability of a succinimide intermediate observed on a therapeutic IgG1 molecule

(2013) David Ouellette et al.   mAbs

Developability studies before initiation of process development

(2013) Xiaoyu Yang et al.   mAbs

Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies

(2012) Yi Du et al.   mAbs

Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars

(2012) Steven A. Berkowitz et al.   NATURE REVIEWS DRUG DISCOVERY

Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions

(2012) J. M. Perchiacca et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Impact of short range hydrophobic interactions and long range electrostatic forces on the aggregation kinetics of a monoclonal antibody and a dual-variable domain immunoglobulin at low and high concentrations

(2011) Vineet Kumar et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Classification and Characterization of Therapeutic Antibody Aggregates

(2011) Marisa K. Joubert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIC resolution of an IgG1 with an oxidized Trp in a complementarity determining region

(2011) Daniel Boyd et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Developability Index: A Rapid In Silico Tool for the Screening of Antibody Aggregation Propensity

(2011) Timothy M. Lauer et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Conformational stability and aggregation of therapeutic monoclonal antibodies studied with ANS and Thioflavin T binding

(2011) Veysel Kayser et al.   mAbs

Analytical methods for physicochemical characterization of antibody drug conjugates

(2011) Aditya Wakankar et al.   mAbs

Separation of oxidized variants of a monoclonal antibody by anion-exchange

(2010) Glen Teshima et al.   JOURNAL OF CHROMATOGRAPHY A

Structure-based engineering of a monoclonal antibody for improved solubility

(2010) S.-J. Wu et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Aggregation-Prone Motifs in Human Immunoglobulin G

(2009) Naresh Chennamsetty et al.   JOURNAL OF MOLECULAR BIOLOGY

Design of therapeutic proteins with enhanced stability

(2009) N. Chennamsetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Separation and Characterization of an IgG2 Antibody Containing a Cyclic Imide in CDR1 of Light Chain by Hydrophobic Interaction Chromatography and Mass Spectrometry

(2008) John Valliere-Douglass et al.   ANALYTICAL CHEMISTRY

O-Fucosylation of an antibody light chain: Characterization of a modification occurring on an IgG1 molecule

(2008) J. F Valliere-Douglass et al.   GLYCOBIOLOGY

Separation of populations of antibody variants by fine tuning of hydrophobic-interaction chromatography operating conditions

(2008) John Valliere-Douglass et al.   JOURNAL OF CHROMATOGRAPHY A

Liquid chromatography of recombinant proteins and protein drugs

(2008) Xindu Geng et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES