Post-translational modification: nature's escape from genetic imprisonment and the basis for dynamic information encoding

Some lessons about models from Michaelis and Menten

(2012) Jeremy Gunawardena   MOLECULAR BIOLOGY OF THE CELL

A Linear Framework for Time-Scale Separation in Nonlinear Biochemical Systems

(2012) Jeremy Gunawardena   PLoS One

The methylproteome and the intracellular methylation network

(2012) Melissa A. Erce et al.   PROTEOMICS

A SUMO-Phospho tag team for wrestling with potassium channel gating: Figure 1.

(2011) Danielle Mandikian et al.   JOURNAL OF GENERAL PHYSIOLOGY

SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neurons

(2011) Leigh D. Plant et al.   JOURNAL OF GENERAL PHYSIOLOGY

Ubiquitin Homeostasis Is Critical for Synaptic Development and Function

(2011) P.-C. Chen et al.   JOURNAL OF NEUROSCIENCE

Human Protein Reference Database and Human Proteinpedia as resources for phosphoproteome analysis

(2011) Renu Goel et al.   Molecular BioSystems

Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation

(2011) Jung-Mao Hsu et al.   NATURE CELL BIOLOGY

Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions

(2011) Carsten Janke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation Barcoding as a Mechanism of Directing GPCR Signaling

(2011) S. B. Liggett   Science Signaling

Distinct Phosphorylation Sites on the  2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of  -Arrestin

(2011) K. N. Nobles et al.   Science Signaling

UniProt Knowledgebase: a hub of integrated protein data

(2011) M. Magrane et al.   Database-The Journal of Biological Databases and Curation

Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database

(2011) George A. Khoury et al.   Scientific Reports

NMR spectroscopy of the neuronal tau protein: normal function and implication in Alzheimer's disease

(2010) Isabelle Landrieu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

High-Affinity Interaction of Poly(ADP-ribose) and the Human DEK Oncoprotein Depends upon Chain Length

(2010) Jörg Fahrer et al.   BIOCHEMISTRY

Greasing Their Way: Lipid Modifications Determine Protein Association with Membrane Rafts

(2010) Ilya Levental et al.   BIOCHEMISTRY

A Family of Protein-Deglutamylating Enzymes Associated with Neurodegeneration

(2010) Krzysztof Rogowski et al.   CELL

Human TUBB3 Mutations Perturb Microtubule Dynamics, Kinesin Interactions, and Axon Guidance

(2010) Max A. Tischfield et al.   CELL

Influence of Combinatorial Histone Modifications on Antibody and Effector Protein Recognition

(2010) Stephen M. Fuchs et al.   CURRENT BIOLOGY

Regulatory mechanisms involved in the control of ubiquitin homeostasis

(2010) Y. Kimura et al.   JOURNAL OF BIOCHEMISTRY

Differential G-protein-coupled Receptor Phosphorylation Provides Evidence for a Signaling Bar Code

(2010) Adrian J. Butcher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Tubulin Deglutamylase amongCaenorhabditis elegansand Mammalian Cytosolic Carboxypeptidases (CCPs)

(2010) Yoshishige Kimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Steroid Receptor Coactivator (SRC) Family: Masters of Systems Biology

(2010) Brian York et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mining recent brain proteomic databases for ion channel phosphosite nuggets

(2010) Oscar Cerda et al.   JOURNAL OF GENERAL PHYSIOLOGY

Phospho.ELM: a database of phosphorylation sites--update 2011

(2010) H. Dinkel et al.   NUCLEIC ACIDS RESEARCH

PHOSIDA 2011: the posttranslational modification database

(2010) F. Gnad et al.   NUCLEIC ACIDS RESEARCH

CPLA 1.0: an integrated database of protein lysine acetylation

(2010) Zexian Liu et al.   NUCLEIC ACIDS RESEARCH

Reprogramming the posttranslational code of SRC-3 confers a switch in mammalian systems biology

(2010) B. York et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton

(2010) Carsten Janke et al.   TRENDS IN NEUROSCIENCES

The regulation of protein phosphorylation

(2009) Louise N. Johnson   BIOCHEMICAL SOCIETY TRANSACTIONS

Multisite protein phosphorylation - from molecular mechanisms to kinetic models

(2009) Carlos Salazar et al.   FEBS Journal

Protein Arginine Methylation in Mammals: Who, What, and Why

(2009) Mark T. Bedford et al.   MOLECULAR CELL

Unlimited multistability in multisite phosphorylation systems

(2009) Matthew Thomson et al.   NATURE

Ubiquitin-binding domains — from structures to functions

(2009) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PhosPhAt: the Arabidopsis thaliana phosphorylation site database. An update

(2009) Pawel Durek et al.   NUCLEIC ACIDS RESEARCH

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Posttranslational Modification of p53: Cooperative Integrators of Function

(2009) D. W. Meek et al.   Cold Spring Harbor Perspectives in Biology

G-Protein-Coupled Receptors: From Classical Modes of Modulation to Allosteric Mechanisms

(2008) Thomas M. Bridges et al.   ACS Chemical Biology

Control of AMPK-related kinases by USP9X and atypical Lys29/Lys33-linked polyubiquitin chains

(2008) Abdallah K. Al-Hakim et al.   BIOCHEMICAL JOURNAL

G-protein-coupled receptor phosphorylation: where, when and by whom

(2008) A B Tobin   BRITISH JOURNAL OF PHARMACOLOGY

The emerging field of dynamic lysine methylation of non-histone proteins

(2008) Jing Huang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS

Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but not binding to microtubules

(2008) Laziza Amniai et al.   FASEB JOURNAL

Coupled Phosphatase and Kinase Switches Produce the Tristability Required for Long-Term Potentiation and Long-Term Depression

(2008) H. J. Pi et al.   JOURNAL OF NEUROSCIENCE

PhosphoPep—a database of protein phosphorylation sites in model organisms

(2008) Bernd Bodenmiller et al.   NATURE BIOTECHNOLOGY

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

(2008) Scott A Yuzwa et al.   Nature Chemical Biology

A complex barcode underlies the heterogeneous response of p53 to stress

(2008) Fiona Murray-Zmijewski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Is there a code embedded in proteins that is based on post-translational modifications?

(2008) Robert J. Sims et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

P3DB: a plant protein phosphorylation database

(2008) J. Gao et al.   NUCLEIC ACIDS RESEARCH

Cross-talk between GlcNAcylation and phosphorylation: Site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc

(2008) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cracking the RNA polymerase II CTD code

(2008) Sylvain Egloff et al.   TRENDS IN GENETICS