Rational selection of building blocks for the assembly of bispecific antibodies

Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab)

(2020) Fernando Garces et al.   Cell Reports

High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry

(2020) William S. Sawyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Native and Denaturing MS Protein Deconvolution for Biopharma: Monoclonal Antibodies and Antibody–Drug Conjugates to Polydisperse Membrane Proteins and Beyond

(2019) Iain D. G. Campuzano et al.   ANALYTICAL CHEMISTRY

Bispecific antibodies: a mechanistic review of the pipeline

(2019) Aran F. Labrijn et al.   NATURE REVIEWS DRUG DISCOVERY

Discovery, characterization, and remediation of a C-terminal Fc-extension in proteins expressed in CHO cells

(2018) Christopher S. Spahr et al.   mAbs

Engineering a bispecific antibody with a common light chain: Identification and optimization of an anti-CD3 epsilon and anti-GPC3 bispecific antibody, ERY974

(2018) Hirotake Shiraiwa et al.   METHODS

Productive common light chain libraries yield diverse panels of high affinity bispecific antibodies

(2017) Thomas Van Blarcom et al.   mAbs

The making of bispecific antibodies

(2017) Ulrich Brinkmann et al.   mAbs

Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia

(2017) Hagop Kantarjian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Generation of human bispecific common light chain antibodies by combining animal immunization and yeast display

(2017) Simon Krah et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Discovery and bio-optimization of human antibody therapeutics using the XenoMouse®transgenic mouse platform

(2016) Ian N. Foltz et al.   IMMUNOLOGICAL REVIEWS

Engineering an IgG Scaffold Lacking Effector Function with Optimized Developability

(2016) Frederick W. Jacobsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells

(2016) Michael Dillon et al.   mAbs

Automated two-step chromatography using an ÄKTA equipped with in-line dilution capability

(2015) Dwight Winters et al.   JOURNAL OF CHROMATOGRAPHY A

Bispecific antibodies and their applications

(2015) Gaowei Fan et al.   Journal of Hematology & Oncology

Alternative molecular formats and therapeutic applications for bispecific antibodies

(2015) Christoph Spiess et al.   MOLECULAR IMMUNOLOGY

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab

(2015) Giovanna Scapin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab

(2015) Giovanna Scapin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human Antibody Production in Transgenic Animals

(2014) Marianne Brüggemann et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Principles and engineering of antibody folding and assembly

(2014) Matthias J. Feige et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Automated high-throughput protein purification using an ÄKTApurifier and a CETAC autosampler

(2014) Daniel Yoo et al.   JOURNAL OF CHROMATOGRAPHY A

Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies

(2011) W. Schaefer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects

(2010) Kannan Gunasekaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies†

(2010) Jonathan H. Davis et al.   PROTEIN ENGINEERING DESIGN & SELECTION

An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies

(2009) Matthias J. Feige et al.   MOLECULAR CELL

How antibodies fold

(2009) Matthias J. Feige et al.   TRENDS IN BIOCHEMICAL SCIENCES

A One Pot, One Step, Precision Cloning Method with High Throughput Capability

(2008) Carola Engler et al.   PLoS One