Structural insights of oxindole based kinase inhibitors as anticancer agents: Recent advances

Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole–Indole Conjugates as Anticancer CDK Inhibitors

(2020) Tarfah Al-Warhi et al.   MOLECULES

Design and Synthesis of 5‐Morpholino‐Thiophene‐Indole/ Oxindole Hybrids as Cytotoxic Agents

(2020) Upasana Yadav et al.   ChemistrySelect

Structural modifications of indolinones bearing a pyrrole moiety and discovery of a multi-kinase inhibitor with potent antitumor activity

(2020) Mingze Qin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors

(2020) Christopher J. Matheson et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dual Targeting of VEGFR2 and C-Met Kinases via the Design and Synthesis of Substituted 3-(Triazolo-thiadiazin-3-yl)indolin-2-one Derivatives as Angiogenesis Inhibitors

(2020) Samy Mohamady et al.   ACS Omega

A comprehensive insight on the recent development of Cyclic Dependent Kinase inhibitors as anticancer agents

(2020) Brilliant N. Marak et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel quinazoline-based EGFR kinase inhibitors: A review focussing on SAR and molecular docking studies (2015-2019)

(2020) Parth Bhatia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies

(2020) Wagdy M. Eldehna et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

How selective are clinical CDK4/6 inhibitors?

(2020) Denisa Hendrychová et al.   MEDICINAL RESEARCH REVIEWS

Design, synthesis, and in vitro and in vivo anti-angiogenesis study of a novel vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor based on 1,2,3-triazole scaffold

(2020) De-pu Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Molecular diversity of trimethoxyphenyl-1,2,3-triazole hybrids as novel colchicine site tubulin polymerization inhibitors

(2019) Dong-Jun Fu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Curcumin as tyrosine kinase inhibitor in cancer treatment

(2019) A. Golonko et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Reliability of Click Chemistry on Drug Discovery: A Personal Account

(2019) Nagula Shankaraiah et al.   CHEMICAL RECORD

Natural products as important tyrosine kinase inhibitors

(2019) Bo Yin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advance in the development of novel, selective and potent FGFR inhibitors

(2019) Feng-Tao Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Properties of FDA-approved small molecule protein kinase inhibitors: A 2020 update

(2019) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Design, synthesis, structure-activity relationships study and X-ray crystallography of 3-substituted-indolin-2-one-5-carboxamide derivatives as PAK4 inhibitors

(2018) Jing Guo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Kinase-targeted cancer therapies: progress, challenges and future directions

(2018) Khushwant S. Bhullar et al.   Molecular Cancer

Kinase inhibitors: the road ahead

(2018) Fleur M. Ferguson et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of a novel 2-oxindole fluorinated derivative as in vivo antitumor agent for prostate cancer acting via AMPK activation

(2018) Alicia Bort et al.   Scientific Reports

Synthesis of enamino-2-oxindoles via conjugate addition between α-azido ketones and 3-alkenyl oxindoles: Cytotoxicity evaluation and apoptosis inducing studies

(2018) Niggula Praveen Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

1,2,3-triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 & tubulin: Their anti-proliferative & anti-inflammatory activity

(2018) Fatima Naaz et al.   BIOORGANIC CHEMISTRY

Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell proliferation and metastasis

(2018) Babita Aneja et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Type IIA - Type IIB protein tyrosine kinase inhibitors hybridization as an efficient approach for potent multikinase inhibitor development: Design, synthesis, anti-proliferative activity, multikinase inhibitory activity and molecular modeling of novel indolinone-based ureides and amides

(2018) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

PLK4: a link between centriole biogenesis and cancer

(2017) Radhika Radha Maniswami et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells

(2017) Wagdy M. Eldehna et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis and Evaluation of Novel 2-Pyrrolidone-Fused (2-Oxoindolin-3-ylidene)methylpyrrole Derivatives as Potential Multi-Target Tyrosine Kinase Receptor Inhibitors

(2017) Ting-Hsuan Yang et al.   MOLECULES

Design, Synthesis and Preliminary Biological Evaluation of Novel Benzyl Sulfoxide 2-Indolinone Derivatives as Anticancer Agents

(2017) Lin Tang et al.   MOLECULES

Synthesis and Evaluation of Novel 2-Pyrrolidone-Fused (2-Oxoindolin-3-ylidene)methylpyrrole Derivatives as Potential Multi-Target Tyrosine Kinase Receptor Inhibitors

(2017) Ting-Hsuan Yang et al.   MOLECULES

The c-Met receptor: Implication for targeted therapies in colorectal cancer

(2017) Elmira Safaie Qamsari et al.   TUMOR BIOLOGY

Dual Inhibition of PDK1 and Aurora Kinase A: An Effective Strategy to Induce Differentiation and Apoptosis of Human Glioblastoma Multiforme Stem Cells

(2016) Simona Daniele et al.   ACS Chemical Neuroscience

Novel triazolothiadiazines act as potent anticancer agents in liver cancer cells through Akt and ASK-1 proteins

(2016) Peri S. Aytaç et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of 4′-O-alkylamino-tethered-benzylideneindolin-2-ones as potent cytotoxic and apoptosis inducing agents

(2016) Kishna Ram Senwar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of novel pyrrolo[2,3-b]pyridine derivatives bearing 1,2,3-triazole moiety as c-Met kinase inhibitors

(2016) Qidong Tang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and optimization of (3-aryl-1 H -indazol-6-yl)spiro[cyclopropane-1,3′-indolin]-2′-ones as potent PLK4 inhibitors with oral antitumor efficacy

(2016) Sze-Wan Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of C3-tethered 1,2,3-triazolo-β-carboline derivatives: Anticancer activity, DNA-binding ability, viscosity and molecular modeling studies

(2016) Nagula Shankaraiah et al.   BIOORGANIC CHEMISTRY

Recent advances in the development of dual VEGFR and c-Met small molecule inhibitors as anticancer drugs

(2016) Jin Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of pyrrolospirooxindole derivatives as novel cyclin dependent kinase 4 (CDK4) inhibitors by catalyst-free, green approach

(2016) Ahmed Kamal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma

(2016) Simona Sestito et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and apoptosis inducing effect of novel (Z)-3-(3′-methoxy-4′-(2-amino-2-oxoethoxy)-benzylidene)indolin-2-ones as potential antitumour agents

(2016) Kishna Ram Senwar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Investigation of triazole-linked indole and oxindole glycoconjugates as potential anticancer agents: novel Akt/PKB signaling pathway inhibitors

(2016) Atulya Nagarsenkar et al.   MedChemComm

Synthesis of 1,2-benzisoxazole tethered 1,2,3-triazoles that exhibit anticancer activity in acute myeloid leukemia cell lines by inhibiting histone deacetylases, and inducing p21 and tubulin acetylation

(2015) Nanjundaswamy Ashwini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme

(2015) Simona Sestito et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of 3-ylideneoxindole acetamides as potent anticancer agents

(2015) Chun-Tang Chiou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Spirooxindole-derived morpholine-fused-1,2,3-triazoles: Design, synthesis, cytotoxicity and apoptosis inducing studies

(2015) Kishna Ram Senwar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

H2O-mediated isatin spiro-epoxide ring opening with NaCN: Synthesis of novel 3-tetrazolylmethyl-3-hydroxy-oxindole hybrids and their anticancer evaluation

(2015) Pankaj Sharma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indoline ureas as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro biological evaluation and molecular docking

(2015) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Spirooxindoles: Promising scaffolds for anticancer agents

(2015) Bin Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nintedanib: From Discovery to the Clinic

(2015) Gerald J. Roth et al.   JOURNAL OF MEDICINAL CHEMISTRY

A one-pot ‘click’ reaction from spiro-epoxides catalyzed by Cu(i)-pyrrolidinyl-oxazole-carboxamide

(2015) Kishna Ram Senwar et al.   NEW JOURNAL OF CHEMISTRY

Design, synthesis and biological evaluation of novel C3-functionalized oxindoles as potential Pim-1 kinase inhibitors

(2015) Hong-bao Sun et al.   RSC Advances

Aurora Kinase Inhibitors: Current Status and Outlook

(2015) Vassilios Bavetsias et al.   Frontiers in Oncology

Synthesis and biological evaluation of novel oxindole-based RTK inhibitors as anti-cancer agents

(2014) Gaozhi Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases

(2014) Sandra W Cowan-Jacob et al.   Future Medicinal Chemistry

The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent

(2014) Peter B. Sampson et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Discovery of Polo-Like Kinase 4 Inhibitors: Design and Optimization of Spiro[cyclopropane-1,3′[3H]indol]-2′(1′H)-ones as Orally Bioavailable Antitumor Agents

(2014) Peter B. Sampson et al.   JOURNAL OF MEDICINAL CHEMISTRY

AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?

(2013) Madhumita Dandapani et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Microtubule Affinity-Regulating Kinase 4: Structure, Function, and Regulation

(2013) Farha Naz et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

The Discovery of PLK4 Inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as Novel Antiproliferative Agents

(2013) Radoslaw Laufer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cyclin-Dependent Kinases as Drug Targets for Cell Growth and Proliferation Disorders. A Role for Systems Biology Approach in Drug Development. Part II—CDKs as Drug Targets in Hypertrophic Cell Growth. Modelling of Drugs Targeting CDKs

(2012) Michael A. Idowu   BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT

Identification of an Aurora Kinase Inhibitor Specific for the Aurora B Isoform

(2012) H. Xie et al.   CANCER RESEARCH

Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

(2012) Girija S. Singh et al.   CHEMICAL REVIEWS

PIM1 kinase as a target for cancer therapy

(2012) Anna Lena Merkel et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The secret life of kinases: functions beyond catalysis

(2011) Jens Rauch et al.   Cell Communication and Signaling

Synthesis and anticancer activity of chalcone-pyrrolobenzodiazepine conjugates linked via 1,2,3-triazole ring side-armed with alkane spacers

(2011) Ahmed Kamal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cyclin-Dependent Kinase Inhibitors as Anticancer Drugs

(2010) Vladimir Krystof et al.   CURRENT DRUG TARGETS

Novel Potent Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitors: Synthesis, Structure−Activity Relationships, and Antitumor Activities of 2-Indolinone Derivatives

(2010) Peng Cho Tang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

(2010) B. W. Murray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

(2009) Jorg Hartmann et al.   CURRENT DRUG METABOLISM

Promise and challenges in drug discovery and development of hybrid anticancer drugs

(2009) Lalji K Gediya et al.   Expert Opinion on Drug Discovery

Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice

(2009) Adam D. Judge et al.   JOURNAL OF CLINICAL INVESTIGATION

1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin

(2008) Kristin Odlo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing ‘click’ chemistry: DNA-binding affinity and anticancer activity

(2008) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Advances of AKT Pathway in Human Oncogenesis and as a Target for Anti-Cancer Drug Discovery

(2008) Lu-Hai Wang et al.   CURRENT CANCER DRUG TARGETS

Potential roles for the PIM1 kinase in human cancer – A molecular and therapeutic appraisal

(2008) Nilesh Shah et al.   EUROPEAN JOURNAL OF CANCER

The Pak4 Protein Kinase Plays a Key Role in Cell Survival and Tumorigenesis in Athymic Mice

(2008) Y. Liu et al.   MOLECULAR CANCER RESEARCH