Reliability of Click Chemistry on Drug Discovery: A Personal Account

Synthesis of substituted biphenyl methylene indolinones as apoptosis inducers and tubulin polymerization inhibitors

(2019) Kavitha Donthiboina et al.   BIOORGANIC CHEMISTRY

Ru(II)-Catalyzed Regioselective Hydroxymethylation of β-Carbolines and Isoquinolines via C–H Functionalization: Probing the Mechanism by Online ESI-MS/MS Screening

(2019) Ramya Tokala et al.   JOURNAL OF ORGANIC CHEMISTRY

Sulfamic acid promoted one-pot synthesis of phenanthrene fused-dihydrodibenzo-quinolinones: Anticancer activity, tubulin polymerization inhibition and apoptosis inducing studies

(2018) Niggula Praveen Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of 1,2,4-triazole-linked urea/thiourea conjugates as cytotoxic and apoptosis inducing agents

(2018) Ramya Tokala et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of DNA-interactive β-carboline-oxindole hybrids as cytotoxic and apoptosis inducing agents

(2018) Shankaraiah Nagula et al.   ChemMedChem

Microwave-assisted one-pot synthesis of new phenanthrene fused-tetrahydrodibenzo-acridinones as potential cytotoxic and apoptosis inducing agents

(2018) Niggula Praveen Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of podophyllotoxin linked β-carboline congeners as potential anticancer agents and DNA topoisomerase II inhibitors

(2018) Manda Sathish et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

H2 O-Mediated Epoxide Ring-Opening with Concomitant C-S Bond Formation: A One-Pot Method to 3-Hydroxy-oxindolino-dithiocarbamates as Cytotoxic Agents

(2018) Sonal Bhandari et al.   ChemistrySelect

Synthesis of DNA interactive C3-trans-cinnamide linked β-carboline conjugates as potential cytotoxic and DNA topoisomerase I inhibitors

(2018) Manda Sathish et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of enamino-2-oxindoles via conjugate addition between α-azido ketones and 3-alkenyl oxindoles: Cytotoxicity evaluation and apoptosis inducing studies

(2018) Niggula Praveen Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and in vitro cytotoxicity evaluation of β-carboline-linked 2,4-thiazolidinedione hybrids: potential DNA intercalation and apoptosis-inducing studies

(2018) Ramya Tokala et al.   NEW JOURNAL OF CHEMISTRY

Synthesis of 2,3,6,7-tetramethoxyphenanthren-9-amine: An efficient precursor to access new 4- aza -2,3-dihydropyridophenanthrenes as apoptosis inducing agents

(2017) Niggula Praveen Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Conventional and microwave-assisted synthesis of new 1 H -benzimidazole-thiazolidinedione derivatives: A potential anticancer scaffold

(2017) Pankaj Sharma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of substituted phenanthrene-9-benzimidazole conjugates: Cytotoxicity evaluation and apoptosis inducing studies

(2017) Niggula Praveen Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 1,2,3-Triazolo-fused-tetrahydro-β-carboline Derivatives via 1,3-Dipolar Cycloaddition Reaction: Cytotoxicity Evaluation and DNA-Binding studies

(2017) Shalini Nekkanti et al.   ChemistrySelect

Bioorthogonal Copper Free Click Chemistry for Labeling and Tracking of Chondrocytes In Vivo

(2016) Hwa In Yoon et al.   BIOCONJUGATE CHEMISTRY

Synthesis and biological evaluation of some novel triazole hybrids of curcumin mimics and their selective anticancer activity against breast and prostate cancer cell lines

(2016) Dhanaraju Mandalapu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of 4′-O-alkylamino-tethered-benzylideneindolin-2-ones as potent cytotoxic and apoptosis inducing agents

(2016) Kishna Ram Senwar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of C3-tethered 1,2,3-triazolo-β-carboline derivatives: Anticancer activity, DNA-binding ability, viscosity and molecular modeling studies

(2016) Nagula Shankaraiah et al.   BIOORGANIC CHEMISTRY

Silver catalyzed domino aza-annulation/Diels–Alder cyclization of 2-ene-yne anilines: a facile one-pot access to carbazole, dihydrocarbazole and tetrahydrocarbazole frameworks

(2016) Namballa Hari Krishna et al.   CHEMICAL COMMUNICATIONS

Synthesis and biological evaluation of new benzimidazole-thiazolidinedione hybrids as potential cytotoxic and apoptosis inducing agents

(2016) Pankaj Sharma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and apoptosis inducing effect of novel (Z)-3-(3′-methoxy-4′-(2-amino-2-oxoethoxy)-benzylidene)indolin-2-ones as potential antitumour agents

(2016) Kishna Ram Senwar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Microwave-assisted direct oxidative synthesis of α-ketoamides from aryl methyl ketones and amines by a water soluble Cu(i)-complex

(2016) Shalini Nekkanti et al.   GREEN CHEMISTRY

A recyclable and water soluble copper(i)-catalyst: one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles and their biological evaluation

(2016) Shalini Nekkanti et al.   RSC Advances

TBAI/TBHP-catalyzed [3 + 2]cycloaddition/oxidation/aromatization cascade and online ESI-MS mechanistic studies: synthesis of pyrrolo[2,1-a]isoquinolines and indolizino[8,7-b]indoles

(2016) Shalini Nekkanti et al.   RSC Advances

Silver(i)-catalysed domino alkyne-annulation/Diels–Alder reaction: a mild synthetic approach to tetrahydrospiro[carbazole-4,3′-indoline] scaffolds

(2016) Pankaj Sharma et al.   Organic Chemistry Frontiers

In Vivo Targeting through Click Chemistry

(2015) Yevgeny Brudno et al.   ChemMedChem

Spirooxindole-derived morpholine-fused-1,2,3-triazoles: Design, synthesis, cytotoxicity and apoptosis inducing studies

(2015) Kishna Ram Senwar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

H2O-mediated isatin spiro-epoxide ring opening with NaCN: Synthesis of novel 3-tetrazolylmethyl-3-hydroxy-oxindole hybrids and their anticancer evaluation

(2015) Pankaj Sharma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Brønsted Acid Catalyzed Asymmetric Diels–Alder Reactions: Stereoselective Construction of Spiro[tetrahydrocarbazole-3,3′-oxindole] Framework

(2015) Yang Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

A one-pot ‘click’ reaction from spiro-epoxides catalyzed by Cu(i)-pyrrolidinyl-oxazole-carboxamide

(2015) Kishna Ram Senwar et al.   NEW JOURNAL OF CHEMISTRY

Implantable biomaterial based on click chemistry for targeting small molecules

(2014) José M. Mejía Oneto et al.   Acta Biomaterialia

Asymmetric Michael addition of ketones to nitroolefins: pyrrolidinyl-oxazole-carboxamides as new efficient organocatalysts

(2014) Ahmed Kamal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A powerful combination: recent achievements on using TBAI and TBHP as oxidation system

(2014) Xiao-Feng Wu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Sequence Specific Binding of Beta Carboline Alkaloid Harmalol with Deoxyribonucleotides: Binding Heterogeneity, Conformational, Thermodynamic and Cytotoxic Aspects

(2014) Sarita Sarkar et al.   PLoS One

Total synthesis of phenanthroindolizidine alkaloids via asymmetric deprotonation of N-Boc-pyrrolidine

(2014) Meng Deng et al.   RSC Advances

Palladium-catalyzed, copper-mediated construction of benzene rings from the reactions of indoles with in situ generated enones

(2014) Tenglong Guo et al.   Organic Chemistry Frontiers

Imaging Cell Surface Glycosylation in Vivo Using “Double Click” Chemistry

(2013) André A. Neves et al.   BIOCONJUGATE CHEMISTRY

Click Chemistry for Drug Development and Diverse Chemical–Biology Applications

(2013) Prakasam Thirumurugan et al.   CHEMICAL REVIEWS

AlCl3–NaI assisted cleavage of polymer-bound esters with concomitant amine coupling and azido-reductive cyclization: synthesis of pyrrolobenzodiazepine derivatives

(2013) Ahmed Kamal et al.   TETRAHEDRON LETTERS

One-shot indole-to-carbazole π-extension by a Pd–Cu–Ag trimetallic system

(2013) Kyohei Ozaki et al.   Chemical Science

Bioorthogonal Copper-Free Click Chemistry In Vivo for Tumor-Targeted Delivery of Nanoparticles

(2012) Heebeom Koo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Soluble Copper(I) Source and Stable Salts of Volatile Ligands for Copper-Catalyzed C–X Couplings

(2012) Peter E. Maligres et al.   JOURNAL OF ORGANIC CHEMISTRY

Genetic Encoding of Bicyclononynes and trans-Cyclooctenes for Site-Specific Protein Labeling in Vitro and in Live Mammalian Cells via Rapid Fluorogenic Diels–Alder Reactions

(2012) Kathrin Lang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

AutoClickChem: Click Chemistry in Silico

(2012) Jacob D. Durrant et al.   PLoS Computational Biology

Click Chemistry: 1,2,3-Triazoles as Pharmacophores

(2011) Sandip G. Agalave et al.   Chemistry-An Asian Journal

Synthesis and anticancer activity of chalcone-pyrrolobenzodiazepine conjugates linked via 1,2,3-triazole ring side-armed with alkane spacers

(2011) Ahmed Kamal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antitumor Agents 288: Design, Synthesis, SAR, and Biological Studies of Novel Heteroatom-Incorporated Antofine and Cryptopleurine Analogues as Potent and Selective Antitumor Agents

(2011) Xiaoming Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A One-Pot Azido Reductive Tandem Mono-N-Alkylation Employing Dialkylboron Triflates: Online ESI-MS Mechanistic Investigation

(2011) Nagula Shankaraiah et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly Efficient Hydrogen-Bonding Catalysis of the Diels–Alder Reaction of 3-Vinylindoles and Methyleneindolinones Provides Carbazolespirooxindole Skeletons

(2011) Bin Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Well-defined copper(i) complexes for Click azide–alkyne cycloaddition reactions: one Click beyond

(2011) Silvia Díez-González   Catalysis Science & Technology

In Vivo Chemistry for Pretargeted Tumor Imaging in Live Mice

(2010) Raffaella Rossin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pharmacokinetics, pharmacodynamics and metabolism of the dimeric pyrrolobenzodiazepine SJG-136 in rats

(2010) Joel M. Reid et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Synthesis of novel sulfanilamide-derived 1,2,3-triazoles and their evaluation for antibacterial and antifungal activities

(2010) Xian-Long Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A New Class of Naphthalimide-Based Antitumor Agents That Inhibit Topoisomerase II and Induce Lysosomal Membrane Permeabilization and Apoptosis

(2010) Zhuo Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tailored Ligand Acceleration of the Cu-Catalyzed Azide−Alkyne Cycloaddition Reaction: Practical and Mechanistic Implications

(2010) Stanislav I. Presolski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of bis-1,2,3-triazolo-bridged unsymmetrical pyrrolobenzodiazepine trimers via ‘click’ chemistry and their DNA-binding studies

(2010) Ahmed Kamal et al.   TETRAHEDRON

Efficient Drug Lead Discovery and Optimization

(2009) William L. Jorgensen   ACCOUNTS OF CHEMICAL RESEARCH

Click chemistry under non-classical reaction conditions

(2009) C. Oliver Kappe et al.   CHEMICAL SOCIETY REVIEWS

Chemoselective Aromatic Azido Reduction with Concomitant Aliphatic Azide Employing Al/Gd Triflates/NaI and ESI-MS Mechanistic Studies

(2009) Ahmed Kamal et al.   CHEMISTRY-A EUROPEAN JOURNAL

Clickable fluorophores for biological labeling—with or without copper

(2009) Péter Kele et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Highly Active Catalyst for Huisgen 1,3-Dipolar Cycloadditions Based on the Tris(triazolyl)methanol−Cu(I) Structure

(2009) Salih Özçubukçu et al.   ORGANIC LETTERS

Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing ‘click’ chemistry: DNA-binding affinity and anticancer activity

(2008) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS

Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity†

(2008) Steven Howard et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Efficient Selective Reduction of Aromatic Azides to Amines Employing BF3·OEt2/NaI: Synthesis of Pyrrolobenzodiazepines

(2008) Ahmed Kamal et al.   SYNLETT

Synthesis of C8–C8/C2–C8-linked triazolo pyrrolobenzodiazepine dimers by employing ‘click’ chemistry and their DNA-binding affinity

(2008) Ahmed Kamal et al.   TETRAHEDRON LETTERS

A facile intramolecular azido/amido reductive cyclization approach: synthesis of pyrrolobenzodiazepines and their dimers

(2008) Ahmed Kamal et al.   TETRAHEDRON LETTERS