Design and Synthesis of 5‐Morpholino‐Thiophene‐Indole/ Oxindole Hybrids as Cytotoxic Agents

Revealing quinquennial anticancer journey of morpholine: A SAR based review

(2019) Fatima Arshad et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of DNA-interactive β-carboline-oxindole hybrids as cytotoxic and apoptosis inducing agents

(2018) Shankaraiah Nagula et al.   ChemMedChem

Diverse Targeted Approaches to Battle Multidrug Resistance in Cancer

(2018) Nagula Shankaraiah et al.   CURRENT MEDICINAL CHEMISTRY

Indole in the target-based design of anticancer agents: A versatile scaffold with diverse mechanisms

(2018) Sakineh Dadashpour et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

H2 O-Mediated Epoxide Ring-Opening with Concomitant C-S Bond Formation: A One-Pot Method to 3-Hydroxy-oxindolino-dithiocarbamates as Cytotoxic Agents

(2018) Sonal Bhandari et al.   ChemistrySelect

Synthesis of enamino-2-oxindoles via conjugate addition between α-azido ketones and 3-alkenyl oxindoles: Cytotoxicity evaluation and apoptosis inducing studies

(2018) Niggula Praveen Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and in vitro cytotoxicity evaluation of β-carboline-linked 2,4-thiazolidinedione hybrids: potential DNA intercalation and apoptosis-inducing studies

(2018) Ramya Tokala et al.   NEW JOURNAL OF CHEMISTRY

Synthesis of substituted phenanthrene-9-benzimidazole conjugates: Cytotoxicity evaluation and apoptosis inducing studies

(2017) Niggula Praveen Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advances (2015–2016) in anticancer hybrids

(2017) Nagaraju Kerru et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view

(2017) Navriti Chadha et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An overview of benzo [b] thiophene-based medicinal chemistry

(2017) Rangappa S. Keri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of Novel Bis(indolyl)-hydrazide–Hydrazone Derivatives as Potent Microtubule-Targeting Cytotoxic Agents against A549 Lung Cancer Cells

(2016) Dipanwita Das Mukherjee et al.   BIOCHEMISTRY

Efficient synthesis of new 2,3-dihydrooxazole-spirooxindoles hybrids as antimicrobial agents

(2016) Shailendra Tiwari et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of 4′-O-alkylamino-tethered-benzylideneindolin-2-ones as potent cytotoxic and apoptosis inducing agents

(2016) Kishna Ram Senwar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Osimertinib: First Global Approval

(2016) Sarah L. Greig   DRUGS

Synthesis and anticholinesterase activity of coumarin-3-carboxamides bearing tryptamine moiety

(2016) Samaneh Ghanei-Nasab et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and apoptosis inducing effect of novel (Z)-3-(3′-methoxy-4′-(2-amino-2-oxoethoxy)-benzylidene)indolin-2-ones as potential antitumour agents

(2016) Kishna Ram Senwar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New ( E )-1-alkyl-1 H -benzo[ d ]imidazol-2-yl)methylene)indolin-2-ones: Synthesis, in vitro cytotoxicity evaluation and apoptosis inducing studies

(2016) Pankaj Sharma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and molecular structure of arene ruthenium(ii) benzhydrazone complexes: impact of substitution at the chelating ligand and arene moiety on antiproliferative activity

(2016) Mohamed Kasim Mohamed Subarkhan et al.   NEW JOURNAL OF CHEMISTRY

Synthesis of 2-aryl-1,2,4-oxadiazolo-benzimidazoles: Tubulin polymerization inhibitors and apoptosis inducing agents

(2015) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Spirooxindole-derived morpholine-fused-1,2,3-triazoles: Design, synthesis, cytotoxicity and apoptosis inducing studies

(2015) Kishna Ram Senwar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

H2O-mediated isatin spiro-epoxide ring opening with NaCN: Synthesis of novel 3-tetrazolylmethyl-3-hydroxy-oxindole hybrids and their anticancer evaluation

(2015) Pankaj Sharma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indole Alkaloids from Catharanthus roseus: Bioproduction and Their Effect on Human Health

(2015) Lorena Almagro et al.   MOLECULES

Synthesis and evaluation of the biological activity of N′-[2-oxo-1,2 dihydro-3H-indol-3-ylidene] benzohydrazides as potential anticancer agents

(2015) Arpit Katiyar et al.   RSC Advances

Phosphatidylinositol 3-Kinase (PI3K) and Phosphatidylinositol 3-Kinase-Related Kinase (PIKK) Inhibitors: Importance of the Morpholine Ring

(2014) Martin Andrs et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in the Willgerodt–Kindler reaction

(2013) Daniel L. Priebbenow et al.   CHEMICAL SOCIETY REVIEWS

Elaboration of thorough simplified vinca alkaloids as antimitotic agents based on pharmacophore similarity

(2013) Jing Zheng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

KLIFS: A Knowledge-Based Structural Database To Navigate Kinase–Ligand Interaction Space

(2013) Oscar P. J. van Linden et al.   JOURNAL OF MEDICINAL CHEMISTRY

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

Synthesis and Antiviral Activity of New Indole-Based Heterocycles

(2010) Hassan Abdel-Gawad et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Antioxidant activity of unexplored indole derivatives: Synthesis and screening

(2010) Mónica S. Estevão et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Drug hybridization strategies: before or after lead identification?

(2009) Carlos Alberto Manssour Fraga   Expert Opinion on Drug Discovery

Resistance to chemotherapy: new treatments and novel insights into an old problem

(2008) S Raguz et al.   BRITISH JOURNAL OF CANCER