Synthesis and Evaluation of Novel 2-Pyrrolidone-Fused (2-Oxoindolin-3-ylidene)methylpyrrole Derivatives as Potential Multi-Target Tyrosine Kinase Receptor Inhibitors

Efficient extravasation of tumor-repopulating cells depends on cell deformability

(2016) Junjian Chen et al.   Scientific Reports

FDA-approved small-molecule kinase inhibitors

(2015) Peng Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Curcumin enhances the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells

(2014) Shu-Mei Lee et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Regorafenib Inhibits Colorectal Tumor Growth through PUMA-Mediated Apoptosis

(2014) D. Chen et al.   CLINICAL CANCER RESEARCH

Aurora Kinase Inhibition Induces PUMA via NF- B to Kill Colon Cancer Cells

(2014) J. Sun et al.   MOLECULAR CANCER THERAPEUTICS

Anticancer activity of SAHA, a potent histone deacetylase inhibitor, in NCI-H460 human large-cell lung carcinoma cells in vitro and in vivo

(2013) YANXIA ZHAO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Crizotinib Induces PUMA-Dependent Apoptosis in Colon Cancer Cells

(2013) X. Zheng et al.   MOLECULAR CANCER THERAPEUTICS

Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6

(2013) Jia Gao et al.   PLoS One

On DABAL-Me3 promoted formation of amides

(2013) Nathalie Dubois et al.   TETRAHEDRON

Positron emission tomography imaging of tumor angiogenesis and monitoring of antiangiogenic efficacy using the novel tetrameric peptide probe 64Cu-cyclam-RAFT-c(-RGDfK-)4

(2012) Zhao-Hui Jin et al.   ANGIOGENESIS

Radioiodinated sunitinib as a potential radiotracer for imaging angiogenesis—radiosynthesis and first radiopharmacological evaluation of 5-[125I]Iodo-sunitinib

(2012) Manuela Kuchar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growth

(2012) C Dudgeon et al.   ONCOGENE

Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors

(2012) M. McTigue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sunitinib inhibits papillary thyroid carcinoma with RET/PTC rearrangement but not BRAF mutation

(2011) Woo-Jin Jeong et al.   CANCER BIOLOGY & THERAPY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Synthesis and Biological Evaluation of 3-Substituted-indolin-2-one Derivatives Containing Chloropyrrole Moieties

(2011) Yun-Zhou Jin et al.   MOLECULES

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

(2011) Theonie Anastassiadis et al.   NATURE BIOTECHNOLOGY

AlMe3-Promoted Formation of Amides from Acids and Amines

(2011) Jianqing Li et al.   ORGANIC LETTERS

Suppression of SOCS3 increases susceptibility of renal cell carcinoma to interferon-α

(2010) Shintaro Tomita et al.   CANCER SCIENCE

Novel Potent Orally Active Multitargeted Receptor Tyrosine Kinase Inhibitors: Synthesis, Structure−Activity Relationships, and Antitumor Activities of 2-Indolinone Derivatives

(2010) Peng Cho Tang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Pyrrole−Indoline-2-ones as Aurora Kinase Inhibitors with a Different Inhibition Profile

(2010) Chao-Cheng Chiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Angiogenesis with Multitargeted Tyrosine Kinase Inhibitors in the Treatment of Non-Small Cell Lung Cancer

(2010) G. Scagliotti et al.   ONCOLOGIST

FerriBRIGHT: A Rationally Designed Fluorescent Probe for Redox Active Metals

(2009) Daniel P. Kennedy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients

(2009) K. S. Gajiwala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

5-Substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor tyrosine kinases

(2008) Naparat Kammasud et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS