PIM1 kinase as a target for cancer therapy

Pim-1 Kinase Expression Predicts Radiation Response in Squamocellular Carcinoma of Head and Neck and Is under the Control of Epidermal Growth Factor Receptor

(2015) Katriina Peltola et al.   NEOPLASIA

7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: A novel class of Pim kinase inhibitors with potent cell antiproliferative activity

(2011) Fabrice Pierre et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors

(2011) Yibin Xiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia

(2011) L. S. Chen et al.   BLOOD

Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma

(2011) D Mahalingam et al.   BRITISH JOURNAL OF CANCER

Review on clinical trials of targeted treatments in malignant mesothelioma

(2011) Jan Nyrop Jakobsen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells

(2011) D. Xu et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

High-Throughput Kinase Profiling: A More Efficient Approach toward the Discovery of New Kinase Inhibitors

(2011) Chandrasekhar V. Miduturu et al.   CHEMISTRY & BIOLOGY

Targeting mTOR Signaling Pathway in Ovarian Cancer

(2011) S. Mabuchi et al.   CURRENT MEDICINAL CHEMISTRY

Using Insights into Pim1 Structure to Design New Anticancer Drugs

(2011) Silvia Schenone et al.   CURRENT PHARMACEUTICAL DESIGN

Targeted Therapies for Metastatic Esophagogastric Cancer

(2011) Deepa Reddy et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

PLK1 as an oncology target: current status and future potential

(2011) Campbell McInnes et al.   DRUG DISCOVERY TODAY

Discovery of Novel Pim-1 Kinase Inhibitors by a Hierarchical Multistage Virtual Screening Approach Based on SVM Model, Pharmacophore, and Molecular Docking

(2011) Ji-Xia Ren et al.   Journal of Chemical Information and Modeling

Overexpression of Pim-1 in bladder cancer

(2011) Shengjie Guo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors

(2011) Li Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted therapies for thyroid tumors

(2011) Steven I Sherman   MODERN PATHOLOGY

The proto-oncogene Pim-1 is a target of miR-33a

(2011) M Thomas et al.   ONCOGENE

ERG Deregulation Induces PIM1 Over-Expression and Aneuploidy in Prostate Epithelial Cells

(2011) Vera Magistroni et al.   PLoS One

PIM1-Activated PRAS40 Regulates Radioresistance in Non-small Cell Lung Cancer Cells through Interplay with FOXO3a, 14-3-3 and Protein Phosphatases

(2011) Wanyeon Kim et al.   RADIATION RESEARCH

Aurora kinase inhibitors as anticancer molecules

(2010) Hiroshi Katayama et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Identification and structure–activity relationship of 8-hydroxy-quinoline-7-carboxylic acid derivatives as inhibitors of Pim-1 kinase

(2010) Faten Sliman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cancer Statistics, 2010

(2010) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma

(2010) Carolin Reiser-Erkan et al.   CANCER BIOLOGY & THERAPY

PIM1 Protein Kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells

(2010) Fengxue Zhang et al.   CANCER BIOLOGY & THERAPY

Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition

(2010) Carmen Blanco-Aparicio et al.   CANCER LETTERS

Drugging the PI3 Kinome: From Chemical Tools to Drugs in the Clinic

(2010) P. Workman et al.   CANCER RESEARCH

miR-328 Functions as an RNA Decoy to Modulate hnRNP E2 Regulation of mRNA Translation in Leukemic Blasts

(2010) Anna M. Eiring et al.   CELL

Targeted Cancer Therapies in the Twenty-First Century: Lessons From Imatinib

(2010) F Stegmeier et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

(2010) Miriam López-Ramos et al.   FASEB JOURNAL

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Why target PIM1 for cancer diagnosis and treatment?

(2010) Nancy S Magnuson et al.   Future Oncology

PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

(2010) L. Brault et al.   HAEMATOLOGICA

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Regulation of Skp2 Levels by the Pim-1 Protein Kinase

(2010) Bo Cen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of Pim-1 is associated with poor prognosis in patients with esophageal squamous cell carcinoma

(2010) Hong-Tao Liu et al.   JOURNAL OF SURGICAL ONCOLOGY

Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion

(2010) Niina M Santio et al.   Molecular Cancer

p53-Dependent Induction of Prostate Cancer Cell Senescence by the PIM1 Protein Kinase

(2010) M. Zemskova et al.   MOLECULAR CANCER RESEARCH

Aurora Kinase Inhibitors - Rising Stars in Cancer Therapeutics?

(2010) A. A. Dar et al.   MOLECULAR CANCER THERAPEUTICS

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

(2010) Klaus Strebhardt   NATURE REVIEWS DRUG DISCOVERY

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

(2010) C A Sparks et al.   ONCOGENE

Hypoxia-Mediated Up-Regulation of Pim-1 Contributes to Solid Tumor Formation

(2009) Jian Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase

(2009) Ron Grey et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

(2009) L. S. Chen et al.   BLOOD

Dissection of PIM serine/threonine kinases in FLT3-ITD–induced leukemogenesis reveals PIM1 as regulator of CXCL12–CXCR4-mediated homing and migration

(2009) Rebekka Grundler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases

(2009) Zhi-Fu Tao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Kinase Inhibitory Potencies, and in Vitro Antiproliferative Evaluation of New Pim Kinase Inhibitors

(2009) Rufine Akué-Gédu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Tumor-associated Autoantigens for the Diagnosis of Colorectal Cancer in Serum Using High Density Protein Microarrays

(2009) Ingrid Babel et al.   MOLECULAR & CELLULAR PROTEOMICS

Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes

(2009) S. M. Mumenthaler et al.   MOLECULAR CANCER THERAPEUTICS

Pim-1 plays a pivotal role in hypoxia-induced chemoresistance

(2009) J Chen et al.   ONCOGENE

PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis

(2009) J J Gu et al.   ONCOGENE

Crystal Structure of the PIM2 Kinase in Complex with an Organoruthenium Inhibitor

(2009) Alex N. Bullock et al.   PLoS One

Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling

(2008) Yunsong Tong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular therapy for the treatment of hepatocellular carcinoma

(2008) T F Greten et al.   BRITISH JOURNAL OF CANCER

Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels

(2008) D. Morishita et al.   CANCER RESEARCH

Extremely Tight Binding of a Ruthenium Complex to Glycogen Synthase Kinase 3

(2008) G. Ekin Atilla-Gokcumen et al.   CHEMBIOCHEM

Similar Biological Activities of Two Isostructural Ruthenium and Osmium Complexes

(2008) Jasna Maksimoska et al.   CHEMISTRY-A EUROPEAN JOURNAL

Potential roles for the PIM1 kinase in human cancer – A molecular and therapeutic appraisal

(2008) Nilesh Shah et al.   EUROPEAN JOURNAL OF CANCER

The PIM1 Kinase Is a Critical Component of a Survival Pathway Activated by Docetaxel and Promotes Survival of Docetaxel-treated Prostate Cancer Cells

(2008) Marina Zemskova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulation of Micro-RNA-1 (miR-1) in Lung Cancer

(2008) Mohd W. Nasser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated Levels of Oncogenic Protein Kinase Pim-1 Induce the p53 Pathway in Cultured Cells and Correlate with Increased Mdm2 in Mantle Cell Lymphoma

(2008) Carol Hogan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primary Cutaneous Marginal Zone B-Cell Lymphomas Are Targeted by Aberrant Somatic Hypermutation

(2008) Alexander J.A. Deutsch et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Docking Study Yields Four Novel Inhibitors of the Protooncogene Pim-1 Kinase†

(2008) Albert C. Pierce et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases

(2008) Zuping Xia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ki67 and PIM1 expression predict outcome in mantle cell lymphoma treated with high dose therapy, stem cell transplantation and rituximab: a Cancer and Leukemia Group B 59909 correlative science study

(2008) Eric D. Hsi et al.   LEUKEMIA & LYMPHOMA

Real-time quantitative RT-PCR assessment of PIM-1 and hK2 mRNA expression in benign prostate hyperplasia and prostate cancer

(2008) Hui-chan He et al.   MEDICAL ONCOLOGY