One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells

Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies

(2017) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cancer stem cells CD133 inhibition and cytotoxicity of certain 3-phenylthiazolo[3,2-a]benzimidazoles: design, direct synthesis, crystal study and in vitro biological evaluation

(2017) Ghada H. Al-Ansary et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents

(2017) Wagdy M. Eldehna et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling

(2017) Hatem Abdel-Aziz et al.   Drug Design Development and Therapy

New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres

(2017) Mohamed I. Attia et al.   PLoS One

Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors

(2016) Madeline E. Kavanagh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis andIn VitroAntiproliferative Activity of Novel Isatin-Quinazoline Hybrids

(2015) Mohamed Fares et al.   ARCHIV DER PHARMAZIE

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Design, synthesis and in vitro antitumor activity of novel N-substituted-4-phenyl/benzylphthalazin-1-ones

(2015) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Spirooxindoles: Promising scaffolds for anticancer agents

(2015) Bin Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel spiropyrazoline oxindoles and evaluation of cytotoxicity in cancer cell lines

(2014) Ângelo Monteiro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Potent Small-Molecule Inhibitor of the MDM2–p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice

(2013) Yujun Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

TTK/hMPS1 Is an Attractive Therapeutic Target for Triple-Negative Breast Cancer

(2013) Virginie Maire et al.   PLoS One

Core Scaffold-Inspired Concise Synthesis of Chiral Spirooxindole-Pyranopyrimidines with Broad-Spectrum Anticancer Potency

(2012) Xianxing Jiang et al.   ADVANCED SYNTHESIS & CATALYSIS

Emerging targeted therapies in triple-negative breast cancer

(2012) J. Crown et al.   ANNALS OF ONCOLOGY

Role of epidermal growth factor receptor in breast cancer

(2012) Hiroko Masuda et al.   BREAST CANCER RESEARCH AND TREATMENT

Targeting EGFR in Triple Negative Breast Cancer

(2012) Naoto T. Ueno et al.   Journal of Cancer

Synthesis and in vitro biological evaluation of new polyamine conjugates as potential anticancer drugs

(2010) Marta Szumilak et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY