Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole–Indole Conjugates as Anticancer CDK Inhibitors

Recent advances in isatin hybrids as potential anticancer agents

(2020) Zhen Ding et al.   ARCHIV DER PHARMAZIE

New Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity

(2020) Reem I. Al-Wabli et al.   Drug Design Development and Therapy

Marine-Inspired Bis-indoles Possessing Antiproliferative Activity against Breast Cancer; Design, Synthesis, and Biological Evaluation

(2020) Wagdy M. Eldehna et al.   Marine Drugs

New thiazol-hydrazono-coumarin hybrids targeting human cervical cancer cells: Synthesis, CDK2 inhibition, QSAR and molecular docking studies

(2019) Somaia S. Abd El-Karim et al.   BIOORGANIC CHEMISTRY

Recent development of CDK inhibitors: An overview of CDK/inhibitor co-crystal structures

(2019) Weiyan Cheng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors

(2019) Natalia A. Lozinskaya et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Updates on the CDK4/6 Inhibitory Strategy and Combinations in Breast Cancer

(2019) Sobhani et al.   Cells

Isatin–azole hybrids and their anticancer activities

(2019) Yani Hou et al.   ARCHIV DER PHARMAZIE

3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights

(2019) Mahmoud F. Abo-Ashour et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Isatin, an endogenous nonpeptide biofactor: A review of its molecular targets, mechanisms of actions, and their biomedical implications

(2018) Alexei Medvedev et al.   BIOFACTORS

Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus

(2018) Gilda Giancotti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of certain hydrazonoindolin-2-one derivatives as new potent anti-proliferative agents

(2018) Wagdy M. Eldehna et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies

(2018) Ahmed Sabt et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation

(2018) Wagdy M. Eldehna et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Novel Thiazolidinone/Thiazolo[3,2-a]Benzimidazolone-Isatin Conjugates as Apoptotic Anti-proliferative Agents Towards Breast Cancer: One-Pot Synthesis and In Vitro Biological Evaluation

(2018) Mohamed El-Naggar et al.   MOLECULES

Role of cyclin-dependent kinase 4/6 inhibitors in the current and future eras of cancer treatment

(2018) S Parylo et al.   JOURNAL OF ONCOLOGY PHARMACY PRACTICE

Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards colon cancer

(2018) Wagdy M. Eldehna et al.   BIOORGANIC CHEMISTRY

Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents

(2018) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell proliferation and metastasis

(2018) Babita Aneja et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Type IIA - Type IIB protein tyrosine kinase inhibitors hybridization as an efficient approach for potent multikinase inhibitor development: Design, synthesis, anti-proliferative activity, multikinase inhibitory activity and molecular modeling of novel indolinone-based ureides and amides

(2018) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting CDK4/6 pathways and beyond in breast cancer

(2018) Domen Ribnikar et al.   BREAST

Fusion of Structure and Ligand Based Methods for Identification of Novel CDK2 Inhibitors

(2017) Priya Mahajan et al.   Journal of Chemical Information and Modeling

Cell-Cycle Therapeutics Come of Age

(2017) Matthew Ingham et al.   JOURNAL OF CLINICAL ONCOLOGY

Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents

(2017) Wagdy M. Eldehna et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling

(2017) Hatem Abdel-Aziz et al.   Drug Design Development and Therapy

New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres

(2017) Mohamed I. Attia et al.   PLoS One

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

CDK4/6 Inhibitors: Promising Opportunities beyond Breast Cancer

(2016) J. S. J. Lim et al.   Cancer Discovery

Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment

(2015) T. VanArsdale et al.   CLINICAL CANCER RESEARCH

Indoline ureas as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro biological evaluation and molecular docking

(2015) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

POSIT: Flexible Shape-Guided Docking For Pose Prediction

(2015) Brian P. Kelley et al.   Journal of Chemical Information and Modeling

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting CDK4 and CDK6: From Discovery to Therapy

(2015) C. J. Sherr et al.   Cancer Discovery

Endpoint of Cancer Treatment: Targeted Therapies

(2014) Mehmet Topcul et al.   Asian Pacific Journal of Cancer Prevention

Novel acylureidoindolin-2-one derivatives as dual Aurora B/FLT3 inhibitors for the treatment of acute myeloid leukemia

(2014) Ajit Dhananjay Jagtap et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Analogue-based design, synthesis and biological evaluation of 3-substituted-(methylenehydrazono)indolin-2-ones as anticancer agents

(2014) Haytham E. Dweedar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bioisosteric replacement of an acylureido moiety attached to an indolin-2-one scaffold with a malonamido or a 2/4-pyridinoylamido moiety produces a selectively potent Aurora-B inhibitor

(2014) Hsiao-Chun Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Crystal Structure, and Biological Activity ofcis/transAmide Rotomers of (Z)-N′-(2-Oxoindolin-3-ylidene)formohydrazide

(2014) Hatem A. Abdel-Aziz et al.   Journal of Chemistry

Substituted indolin-2-ones as p90 ribosomal S6 protein kinase 2 (RSK2) inhibitors: Molecular docking simulation and structure–activity relationship analysis

(2013) Ye Zhong et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

(2013) S. Lim et al.   DEVELOPMENT

Advances in the development of hybrid anticancer drugs

(2013) Sébastien Fortin et al.   Expert Opinion on Drug Discovery

The Discovery of PLK4 Inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as Novel Antiproliferative Agents

(2013) Radoslaw Laufer et al.   JOURNAL OF MEDICINAL CHEMISTRY

A series of 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles as potent cytotoxic agents

(2012) Dalip Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

FRED and HYBRID docking performance on standardized datasets

(2012) Mark McGann   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

FRED Pose Prediction and Virtual Screening Accuracy

(2011) Mark McGann   Journal of Chemical Information and Modeling

Conformer Generation with OMEGA: Algorithm and Validation Using High Quality Structures from the Protein Databank and Cambridge Structural Database

(2010) Paul C. D. Hawkins et al.   Journal of Chemical Information and Modeling

Drawing the PDB: Protein−Ligand Complexes in Two Dimensions

(2010) Katrin Stierand et al.   ACS Medicinal Chemistry Letters

Cell cycle kinases as therapeutic targets for cancer

(2009) Silvia Lapenna et al.   NATURE REVIEWS DRUG DISCOVERY

Crystal structure of human CDK4 in complex with a D-type cyclin

(2009) P. J. Day et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A History of Cancer Chemotherapy

(2008) Vincent T. DeVita et al.   CANCER RESEARCH