Type IIA - Type IIB protein tyrosine kinase inhibitors hybridization as an efficient approach for potent multikinase inhibitor development: Design, synthesis, anti-proliferative activity, multikinase inhibitory activity and molecular modeling of novel indolinone-based ureides and amides

Title

Type IIA - Type IIB protein tyrosine kinase inhibitors hybridization as an efficient approach for potent multikinase inhibitor development: Design, synthesis, anti-proliferative activity, multikinase inhibitory activity and molecular modeling of novel indolinone-based ureides and amides

Authors

Keywords

Multikinase inhibitor, Synthesis, Indolinone, Molecular modeling, VEGFR-2, FGFR-1 and PDGFR-b

Journal

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Volume 163, Issue -, Pages 37-53

Publisher

Elsevier BV

Online

2018-11-25

DOI

10.1016/j.ejmech.2018.11.061