Design and optimization of (3-aryl-1 H -indazol-6-yl)spiro[cyclopropane-1,3′-indolin]-2′-ones as potent PLK4 inhibitors with oral antitumor efficacy

Authors

Keywords

Polo-like kinase 4, PLK4 inhibitors, Spiro[cyclopropane-1,3′-indolin]-2′-ones, (1, H, -Indazol-6-yl)-methylene)indolin-2-ones, Antitumor agent

Journal

Volume 26, Issue 19, Pages 4625-4630

Publisher

Elsevier BV

Online

2016-08-26

DOI

10.1016/j.bmcl.2016.08.063

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