Pharmacological Manipulation of Translation as a Therapeutic Target for Chronic Pain

Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model

(2020) Simrika Thapa et al.   MOLECULAR NEUROBIOLOGY

Translational Regulations in Response to Endoplasmic Reticulum Stress in Cancers

(2020) Manon Jaud et al.   Cells

Metformin limits osteoarthritis development and progression through activation of AMPK signalling

(2020) Jun Li et al.   ANNALS OF THE RHEUMATIC DISEASES

In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3

(2020) Gerard Callejo et al.   BIOCHEMICAL PHARMACOLOGY

Effects of mTOR inhibitors on neuropathic pain revealed by optical imaging of the insular cortex in rats

(2020) Kyeongmin Kim et al.   BRAIN RESEARCH

Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis

(2020) Jianling Xie et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Retrospective on eIF2A—and Not the Alpha Subunit of eIF2

(2020) Anton A. Komar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Type I Interferons Act Directly on Nociceptors to Produce Pain Sensitization: Implications for Viral Infection-Induced Pain

(2020) Paulino Barragán-Iglesias et al.   JOURNAL OF NEUROSCIENCE

eIF4E phosphorylation modulates pain and neuroinflammation in the aged

(2020) Prapti H. Mody et al.   GeroScience

eIF2B activator prevents neurological defects caused by a chronic integrated stress response

(2019) Yao Liang Wong et al.   eLife

Transcriptome Analysis of the Human Tibial Nerve Identifies Sexually Dimorphic Expression of Genes Involved in Pain, Inflammation, and Neuro-Immunity

(2019) Pradipta R. Ray et al.   Frontiers in Molecular Neuroscience

Targeting super-enhancer-driven oncogenic transcription by CDK7 inhibition in anaplastic thyroid cancer

(2019) Xinyi Cao et al.   THYROID

Small molecule ISRIB suppresses the integrated stress response within a defined window of activation

(2019) Huib H. Rabouw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrophysiological and transcriptomic correlates of neuropathic pain in human dorsal root ganglion neurons

(2019) Robert Y North et al.   BRAIN

A phase II, open label, randomized, noncomparative study of eFT508 (tomivosertib) alone or in combination with avelumab in subjects with relapsed/refractory microsatellite stable colorectal cancer (MSS CRC).

(2019) Joleen Marie Hubbard et al.   JOURNAL OF CLINICAL ONCOLOGY

The Role of Voltage-Gated Sodium Channels in Pain Signaling

(2019) David L. Bennett et al.   PHYSIOLOGICAL REVIEWS

The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors

(2019) Mohamed Mahameed et al.   Cell Death & Disease

First‐in‐Human, Healthy Volunteers Integrated Protocol of ETC‐206, an Oral Mnk 1/2 Kinase Inhibitor Oncology Drug

(2019) Vincenzo Teneggi et al.   CTS-Clinical and Translational Science

Differences between dorsal root and trigeminal ganglion nociceptors in mice revealed by translational profiling

(2019) Salim Megat et al.   JOURNAL OF NEUROSCIENCE

Indirect AMPK activators prevent incision-induced hyperalgesia and block hyperalgesic priming while positive allosteric modulators only block priming in mice

(2019) Kufreobong Inyang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pharmacological targeting of the unfolded protein response for disease intervention

(2019) Claudio Hetz et al.   Nature Chemical Biology

Structural basis for the inhibition of translation through eIF2α phosphorylation

(2019) Yuliya Gordiyenko et al.   Nature Communications

Discovery of novel Mnk inhibitors using mutation‐based induced‐fit virtual high‐throughput screening

(2019) Rama K. Mishra et al.   Chemical Biology & Drug Design

Local translation in neuronal processes

(2019) Anne Biever et al.   CURRENT OPINION IN NEUROBIOLOGY

Structural insights into ISRIB, a memory‐enhancing inhibitor of the integrated stress response

(2019) Aditya A. Anand et al.   FEBS Journal

Transcription Repressor Hes1 Contributes to Neuropathic Pain Development by Modifying CDK9/RNAPII-Dependent Spinal mGluR5 Transcription

(2019) Ming-Chun Hsieh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metformin reduces c-Fos and ATF3 expression in the dorsal root ganglia and protects against oxaliplatin-induced peripheral sensory neuropathy in mice

(2019) Anamaria Falcão Pereira et al.   NEUROSCIENCE LETTERS

AMP-activated protein kinase (AMPK) activator drugs reduce mechanical allodynia in a mouse model of low back pain

(2019) Vaskar Das et al.   REGIONAL ANESTHESIA AND PAIN MEDICINE

Specialized cutaneous Schwann cells initiate pain sensation

(2019) Hind Abdo et al.   SCIENCE

Reversal of peripheral nerve injury-induced neuropathic pain and cognitive dysfunction via genetic and tomivosertib targeting of MNK

(2019) Stephanie Shiers et al.   NEUROPSYCHOPHARMACOLOGY

Stereotyped transcriptomic transformation of somatosensory neurons in response to injury

(2019) Minh Q Nguyen et al.   eLife

Endoplasmic Reticulum Stress Contributes to Nociception via Neuroinflammation in a Murine Bone Cancer Pain Model

(2019) Yanting Mao et al.   ANESTHESIOLOGY

Hyperactive Akt-mTOR pathway as a therapeutic target for pain hypersensitivity in Cntnap2-deficient mice

(2019) Xiaoliang Xing et al.   NEUROPHARMACOLOGY

Spinal Circuits for Touch, Pain, and Itch

(2018) Stephanie C. Koch et al.   Annual Review of Physiology

Brain-derived neurotrophic factor derived from sensory neurons plays a critical role in chronic pain

(2018) Shafaq Sikandar et al.   BRAIN

Beyond symptomatic relief for chemotherapy-induced peripheral neuropathy: Targeting the source

(2018) Jiacheng Ma et al.   CANCER

Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism

(2018) Rong Ke et al.   CELL BIOLOGY INTERNATIONAL

eIF2A, an initiator tRNA carrier refractory to eIF2α kinases, functions synergistically with eIF5B

(2018) Eunah Kim et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Blocking Mammalian Target of Rapamycin (mTOR) Alleviates Neuropathic Pain Induced by Chemotherapeutic Bortezomib

(2018) Zongsheng Duan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Kinetic analyses of phosphorylated and non-phosphorylated eIFiso4E binding to mRNA cap analogues

(2018) Mateen A. Khan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Role of metformin in oxaliplatin-induced peripheral neuropathy in patients with stage III colorectal cancer: randomized, controlled study

(2018) Basma Mahrous El-fatatry et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

The Inside Story of Adenosine

(2018) Marcella Camici et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The luminal domain of the ER stress sensor protein PERK binds misfolded proteins and thereby triggers PERK oligomerization

(2018) Peng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Sephin1-insensitive tripartite holophosphatase dephosphorylates translation initiation factor 2α

(2018) Ana Crespillo-Casado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-based Design of Pyridone–Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition

(2018) Siegfried H. Reich et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia

(2018) Haiyan Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Loss of eIF4E phosphorylation engenders depression-like behaviors via selective mRNA translation

(2018) Inês Silva Amorim et al.   JOURNAL OF NEUROSCIENCE

Neuropathic pain creates an enduring prefrontal cortex dysfunction corrected by the type II diabetic drug metformin but not by gabapentin

(2018) Stephanie Shiers et al.   JOURNAL OF NEUROSCIENCE

Signaling Pathways Involved in the Regulation of mRNA Translation

(2018) Philippe P. Roux et al.   MOLECULAR AND CELLULAR BIOLOGY

Pain-Relieving Effects of mTOR Inhibitor in the Anterior Cingulate Cortex of Neuropathic Rats

(2018) Sun Woo Um et al.   MOLECULAR NEUROBIOLOGY

Transition to chronic pain: opportunities for novel therapeutics

(2018) Theodore J. Price et al.   NATURE REVIEWS NEUROSCIENCE

How central is central poststroke pain? The role of afferent input in poststroke neuropathic pain

(2018) Simon Haroutounian et al.   PAIN

Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B

(2018) Alisa F. Zyryanova et al.   SCIENCE

Locally translated mTOR controls axonal local translation in nerve injury

(2018) Marco Terenzio et al.   SCIENCE

Anti-inflammatory effects of Metformin improve the neuropathic pain and locomotor activity in spinal cord injured rats: introduction of an alternative therapy

(2018) Khashayar Afshari et al.   SPINAL CORD

ER Proteostasis Control of Neuronal Physiology and Synaptic Function

(2018) Gabriela Martínez et al.   TRENDS IN NEUROSCIENCES

Translational Control Mechanisms in Persistent Pain

(2018) Arkady Khoutorsky et al.   TRENDS IN NEUROSCIENCES

eIF4E Phosphorylation Influences Bdnf mRNA Translation in Mouse Dorsal Root Ganglion Neurons

(2018) Jamie K. Moy et al.   Frontiers in Cellular Neuroscience

Principles of Translational Control

(2018) John W.B. Hershey et al.   Cold Spring Harbor Perspectives in Biology

Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice

(2018) Paulino Barragán-Iglesias et al.   Nature Communications

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E

(2018) Argel Aguilar-Valles et al.   Nature Communications

Demonstration of ion channel synthesis by isolated squid giant axon provides functional evidence for localized axonal membrane protein translation

(2018) Chhavi Mathur et al.   Scientific Reports

The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress

(2018) Justine Lebeau et al.   Cell Reports

The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes

(2018) Yao Liang Wong et al.   eLife

A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1

(2018) Yumi Matsui et al.   Acta Crystallographica Section F-Structural Biology Communications

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Translation deregulation in human disease

(2018) Soroush Tahmasebi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of the integrated stress response in nociceptors drives methylglyoxal induced pain

(2018) Paulino Barragán-Iglesias et al.   PAIN

Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults — United States, 2016

(2018) James Dahlhamer et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis

(2018) Yanan Chen et al.   BRAIN

Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold

(2018) Xin Jin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

STIM2 interacts with AMPK and regulates calcium-induced AMPK activation

(2018) Anoop Singh Chauhan et al.   FASEB JOURNAL

Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain

(2018) Salim Megat et al.   JOURNAL OF NEUROSCIENCE

Endoplasmic Reticulum Stress in the Dorsal Root Ganglion Contributes to the Development of Pain Hypersensitivity after Nerve Injury

(2018) Yosuke Yamaguchi et al.   NEUROSCIENCE

The IASP classification of chronic pain for ICD-11

(2018) Michael Nicholas et al.   PAIN

The antidiabetic drug metformin prevents and reverses neuropathic pain and spinal cord microglial activation in male but not female mice

(2018) Kufreobong E. Inyang et al.   PHARMACOLOGICAL RESEARCH

RNA Splicing and Disease: Animal Models to Therapies

(2018) Matías Montes et al.   TRENDS IN GENETICS

The Role of the Eukaryotic Translation Initiation Factor 4E (eIF4E) in Neuropsychiatric Disorders

(2018) Inês S. Amorim et al.   Frontiers in Genetics

Non-AUG translation: a new start for protein synthesis in eukaryotes

(2017) Michael G. Kearse et al.   GENES & DEVELOPMENT

Epiregulin and EGFR interactions are involved in pain processing

(2017) Loren J. Martin et al.   JOURNAL OF CLINICAL INVESTIGATION

Accumulation of methylglyoxal increases the advanced glycation end-product levels in DRG and contributes to lumbar disk herniation-induced persistent pain

(2017) Cui-Cui Liu et al.   JOURNAL OF NEUROPHYSIOLOGY

The MNK–eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain

(2017) Jamie K. Moy et al.   JOURNAL OF NEUROSCIENCE

The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling

(2017) Alexander R. van Vliet et al.   MOLECULAR CELL

Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors

(2017) Marta Carrara et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pharmacological activation of AMPK inhibits incision-evoked mechanical hypersensitivity and the development of hyperalgesic priming in mice

(2017) Michael D. Burton et al.   NEUROSCIENCE

Nerve growth factor locally sensitizes nociceptors in human skin

(2017) Otilia Obreja et al.   PAIN

From Mechanism to Cure: Renewing the Goal to Eliminate the Disease of Pain

(2017) Theodore J. Price et al.   PAIN MEDICINE

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

(2017) Robert W. Myers et al.   SCIENCE

Nociceptor Sensory Neuron–Immune Interactions in Pain and Inflammation

(2017) Felipe A. Pinho-Ribeiro et al.   TRENDS IN IMMUNOLOGY

Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase

(2017) Danqing Feng et al.   ACS Medicinal Chemistry Letters

Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors

(2017) Marta Carrara et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz

(2017) Ana Crespillo-Casado et al.   eLife

Inhibition of Mammalian Target of Rapamycin (mTOR) Signaling in the Insular Cortex Alleviates Neuropathic Pain after Peripheral Nerve Injury

(2017) Minjee Kwon et al.   Frontiers in Molecular Neuroscience

Aberrant plasticity of peripheral sensory axons in a painful neuropathy

(2017) Takashi Hirai et al.   Scientific Reports

Activation of the EIF2AK4-EIF2A/eIF2α-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasiveEscherichia coliinfection

(2016) Alexis Bretin et al.   Autophagy

Recent progress in the identification of adenosine monophosphate-activated protein kinase (AMPK) activators

(2016) Kimberly O. Cameron et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Endoplasmic reticulum stress and the unfolded protein response in disorders of myelinating glia

(2016) Benjamin L.L. Clayton et al.   BRAIN RESEARCH

The eIF2A knockout mouse

(2016) Andrei Golovko et al.   CELL CYCLE

mRNA length-sensing in eukaryotic translation: reconsidering the “closed loop” and its implications for translational control

(2016) Mary K. Thompson et al.   CURRENT GENETICS

The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress

(2016) W. Rozpedek et al.   CURRENT MOLECULAR MEDICINE

Origin of axonal proteins: Is the axon-schwann cell unit a functional syncytium?

(2016) Rodrigo López-Leal et al.   Cytoskeleton

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Ribosome Elongation Stall Directs Gene-specific Translation in the Integrated Stress Response

(2016) Sara K. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Upstream Open Reading Frames Differentially Regulate Gene-specific Translation in the Integrated Stress Response

(2016) Sara K. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

(2016) Hi-Jai R. Shin et al.   NATURE

An mRNA-specific tRNAicarrier eIF2A plays a pivotal role in cell proliferation under stress conditions: stress-resistant translation of c-Src mRNA is mediated by eIF2A

(2016) Oh Sung Kwon et al.   NUCLEIC ACIDS RESEARCH

Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis

(2016) J Musa et al.   ONCOGENE

Targeted overexpression of tumor necrosis factor-α increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neurons

(2016) Pablo Rozas et al.   PAIN

eIF2α phosphorylation controls thermal nociception

(2016) Arkady Khoutorsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translation from the 5' untranslated region shapes the integrated stress response

(2016) S. R. Starck et al.   SCIENCE

Metformin increases pressure pain threshold in lean women with polycystic ovary syndrome

(2016) Marta Kialka et al.   Drug Design Development and Therapy

Adenosine Monophosphate–activated Protein Kinase Regulates Interleukin-1β Expression and Glial Glutamate Transporter Function in Rodents with Neuropathic Pain

(2015) Dylan W. Maixner et al.   ANESTHESIOLOGY

Mechanisms and Regulation of Alternative Pre-mRNA Splicing

(2015) Yeon Lee et al.   Annual Review of Biochemistry

Differential regulation by AMP and ADP of AMPK complexes containing different   subunit isoforms

(2015) F. A. Ross et al.   BIOCHEMICAL JOURNAL

Mnks, eIF4E phosphorylation and cancer

(2015) Christopher G. Proud   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients

(2015) Elísabet Alcocer-Gómez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

(2015) D Grahame Hardie   CURRENT OPINION IN CELL BIOLOGY

Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia

(2015) Jiao Liu et al.   EXPERIMENTAL NEUROLOGY

mTOR Inhibition Induces EGFR Feedback Activation in Association with Its Resistance to Human Pancreatic Cancer

(2015) Feng Wei et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery of 1H-Pyrazol-3(2H)-ones as Potent and Selective Inhibitors of Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK)

(2015) Adrian L. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Accounting for the Delay in the Transition from Acute to Chronic Pain: Axonal and Nuclear Mechanisms

(2015) L. F. Ferrari et al.   JOURNAL OF NEUROSCIENCE

Distinct Terminal and Cell Body Mechanisms in the Nociceptor Mediate Hyperalgesic Priming

(2015) Luiz F. Ferrari et al.   JOURNAL OF NEUROSCIENCE

The S6K protein family in health and disease

(2015) Mariana R. Tavares et al.   LIFE SCIENCES

The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK

(2015) Jeng Yie Chan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation

(2015) Xiaodi Su et al.   NATURE IMMUNOLOGY

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

Metformin: Potential Analgesic?

(2015) Brett Smith et al.   PAIN MEDICINE

Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching

(2015) Yu Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain

(2015) Bora Inceoglu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

(2015) I. Das et al.   SCIENCE

Mutations in a translation initiation factor identify the target of a memory-enhancing compound

(2015) Y. Sekine et al.   SCIENCE

Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic

(2015) Sharon W. Way et al.   Nature Communications

Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma

(2015) Stacey L. Lehman et al.   Scientific Reports

Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase

(2015) Meng S. Choy et al.   Cell Reports

mTOR Kinase: A Possible Pharmacological Target in the Management of Chronic Pain

(2015) Lucia Lisi et al.   Biomed Research International

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

(2015) Carmela Sidrauski et al.   eLife

Translation of 5′ leaders is pervasive in genes resistant to eIF2 repression

(2015) Dmitry E Andreev et al.   eLife

mLST8 Promotes mTOR-Mediated Tumor Progression

(2015) Kyoko Kakumoto et al.   PLoS One

Targeting Mnks for Cancer Therapy

(2015) Jinqiang Hou et al.   Oncotarget

A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake

(2014) Aurélie D. Timmermans et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

AMPK—Sensing Energy while Talking to Other Signaling Pathways

(2014) D. Grahame Hardie   Cell Metabolism

Nociceptive Sensitization Reduces Predation Risk

(2014) Robyn J. Crook et al.   CURRENT BIOLOGY

Resveratrol reduces morphine tolerance by inhibiting microglial activation via AMPK signalling

(2014) Y. Han et al.   EUROPEAN JOURNAL OF PAIN

Opioid receptor–triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia

(2014) Ji-Tian Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Control of Paip1-Eukayrotic Translation Initiation Factor 3 Interaction by Amino Acids through S6 Kinase

(2014) Y. Martineau et al.   MOLECULAR AND CELLULAR BIOLOGY

PERK-Dependent Activation of JAK1 and STAT3 Contributes to Endoplasmic Reticulum Stress-Induced Inflammation

(2014) G. P. Meares et al.   MOLECULAR AND CELLULAR BIOLOGY

Local Translation and Retrograde Axonal Transport of CREB Regulates IL-6-Induced Nociceptive Plasticity

(2014) Ohannes K Melemedjian et al.   Molecular Pain

Peripheral nervous system origin of phantom limb pain

(2014) Apostol Vaso et al.   PAIN

Primary afferent input critical for maintaining spontaneous pain in peripheral neuropathy

(2014) Simon Haroutounian et al.   PAIN

The Anti-Diabetic Drug Metformin Protects against Chemotherapy-Induced Peripheral Neuropathy in a Mouse Model

(2014) Qi-Liang Mao-Ying et al.   PLoS One

Pharmacogenetic Inhibition of eIF4E-Dependent Mmp9 mRNA Translation Reverses Fragile X Syndrome-like Phenotypes

(2014) Christos G. Gkogkas et al.   Cell Reports

Involvement of Endoplasmic Reticulum Stress Response in Orofacial Inflammatory Pain

(2014) Eun Sun Yang et al.   Experimental Neurobiology

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014

(2013) Kurt G. Pike et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

mTOR and its downstream pathway are activated in the dorsal root ganglion and spinal cord after peripheral inflammation, but not after nerve injury

(2013) Lingli Liang et al.   BRAIN RESEARCH

Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a)

(2013) Rebecca L. Stead et al.   FEBS LETTERS

Schwann cell-derived exosomes enhance axonal regeneration in the peripheral nervous system

(2013) María Alejandra Lopez-Verrilli et al.   GLIA

Peripheral Administration of Translation Inhibitors Reverses Increased Hyperalgesia in a Model of Chronic Pain in the Rat

(2013) Luiz F. Ferrari et al.   JOURNAL OF PAIN

Phosphorylation of BRAF by AMPK Impairs BRAF-KSR1 Association and Cell Proliferation

(2013) Che-Hung Shen et al.   MOLECULAR CELL

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program

(2013) C Chauvin et al.   ONCOGENE

The fundamental unit of pain is the cell

(2013) David B. Reichling et al.   PAIN

mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK

(2013) Ohannes K. Melemedjian et al.   PAIN

Deletion of the eIF2α Kinase GCN2 Fails to Rescue the Memory Decline Associated with Alzheimer’s Disease

(2013) Latha Devi et al.   PLoS One

Structural basis of AMPK regulation by small molecule activators

(2013) Bing Xiao et al.   Nature Communications

Gene Expression Regulation by Upstream Open Reading Frames and Human Disease

(2013) Cristina Barbosa et al.   PLoS Genetics

Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

Role of PRAS40 in Akt and mTOR signaling in health and disease

(2012) Claudia Wiza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Heme-regulated eIF2  kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis

(2012) R. N. V. S. Suragani et al.   BLOOD

Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes

(2012) Subir K. Roy Chowdhury et al.   BRAIN

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern

(2012) D. Grahame Hardie et al.   CHEMISTRY & BIOLOGY

Tissue-Specific Coupling between Insulin/IGF and TORC1 Signaling via PRAS40 in Drosophila

(2012) Cristina Pallares-Cartes et al.   DEVELOPMENTAL CELL

The Economic Costs of Pain in the United States

(2012) Darrell J. Gaskin et al.   JOURNAL OF PAIN

Resveratrol Engages AMPK to Attenuate ERK and mTOR Signaling in Sensory Neurons and Inhibits Incision-Induced Acute and Chronic Pain

(2012) Dipti V Tillu et al.   Molecular Pain

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

(2012) Angelika Bierhaus et al.   NATURE MEDICINE

The Elongation, Termination, and Recycling Phases of Translation in Eukaryotes

(2012) T. E. Dever et al.   Cold Spring Harbor Perspectives in Biology

Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism

(2012) Thomas D. Baird et al.   Advances in Nutrition

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

Biphasic Activation of Extracellular Signal-regulated Kinase in Anterior Cingulate Cortex Distinctly Regulates the Development of Pain-related Anxiety and Mechanical Hypersensitivity in Rats after Incision

(2011) Ru-Ping Dai et al.   ANESTHESIOLOGY

Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases

(2011) B. W. Konicek et al.   CANCER RESEARCH

ATP-Competitive Inhibitors of mTOR: An Update

(2011) S. Schenone et al.   CURRENT MEDICINAL CHEMISTRY

NaV1.7 accumulates and co-localizes with phosphorylated ERK1/2 within transected axons in early experimental neuromas

(2011) Anna-Karin Persson et al.   EXPERIMENTAL NEUROLOGY

Autophosphorylation of heme-regulated eukaryotic initiation factor 2α kinase and the role of the modification in catalysis

(2011) Jotaro Igarashi et al.   FEBS Journal

Morphological evidence for a transport of ribosomes from Schwann cells to regenerating axons

(2011) Felipe A. Court et al.   GLIA

Relationship of Axonal Voltage-gated Sodium Channel 1.8 (NaV1.8) mRNA Accumulation to Sciatic Nerve Injury-induced Painful Neuropathy in Rats

(2011) Supanigar Ruangsri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to EnhanceCHOPTranslation

(2011) Lakshmi Reddy Palam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into the Allosteric Effects of 4EBP1 on the Eukaryotic Translation Initiation Factor eIF4E

(2011) Nadeem Siddiqui et al.   JOURNAL OF MOLECULAR BIOLOGY

Spinal Phosphinositide 3-Kinase-Akt-Mammalian Target of Rapamycin Signaling Cascades in Inflammation-Induced Hyperalgesia

(2011) Q. Xu et al.   JOURNAL OF NEUROSCIENCE

Everolimus-based, calcineurin-inhibitor-free regimen in recipients of de-novo kidney transplants: an open-label, randomised, controlled trial

(2011) Klemens Budde et al.   LANCET

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Targeting Adenosine Monophosphate-Activated Protein Kinase (AMPK) in Preclinical Models Reveals a Potential Mechanism for the Treatment of Neuropathic Pain

(2011) Ohannes K Melemedjian et al.   Molecular Pain

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis

(2011) Francis X. McCormack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2/mTOR

(2011) M Rosner et al.   ONCOGENE

Systemic inhibition of the mammalian target of rapamycin (mTOR) pathway reduces neuropathic pain in mice

(2011) Ilona Obara et al.   PAIN

Microneurographic identification of spontaneous activity in C-nociceptors in neuropathic pain states in humans and rats

(2011) Jordi Serra et al.   PAIN

Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

(2011) P. Tsaytler et al.   SCIENCE

Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1

(2010) Emmani B.M. Nascimento et al.   CELLULAR SIGNALLING

Recent advances in the discovery of small molecule mTOR inhibitors

(2010) Abhijit Roychowdhury et al.   Future Medicinal Chemistry

Discovery of Mitogen-Activated Protein Kinase-Interacting Kinase 1 Inhibitors by a Comprehensive Fragment-Oriented Virtual Screening Approach

(2010) Julen Oyarzabal et al.   JOURNAL OF MEDICINAL CHEMISTRY

IL-6- and NGF-Induced Rapid Control of Protein Synthesis and Nociceptive Plasticity via Convergent Signaling to the eIF4F Complex

(2010) O. K. Melemedjian et al.   JOURNAL OF NEUROSCIENCE

Mammalian Target of Rapamycin Signaling in the Spinal Cord Is Required for Neuronal Plasticity and Behavioral Hypersensitivity Associated With Neuropathy in the Rat

(2010) Curtis O. Asante et al.   JOURNAL OF PAIN

Postnatal Deamidation of 4E-BP2 in Brain Enhances Its Association with Raptor and Alters Kinetics of Excitatory Synaptic Transmission

(2010) Michael Bidinosti et al.   MOLECULAR CELL

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mammalian target of rapamycin in spinal cord neurons mediates hypersensitivity induced by peripheral inflammation

(2010) E. Norsted Gregory et al.   NEUROSCIENCE

 -Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

(2010) J. S. Oakhill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

(2010) L. Furic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity

(2009) C. M. Chresta et al.   CANCER RESEARCH

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Recent mechanistic insights into eukaryotic ribosomes

(2009) Marina V Rodnina et al.   CURRENT OPINION IN CELL BIOLOGY

Translating nociceptor sensitivity: the role of axonal protein synthesis in nociceptor physiology

(2009) Theodore J. Price et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Reflex sympathetic dystrophy in patients with metastatic renal cell carcinoma treated with Everolimus

(2009) Christophe Massard et al.   INVESTIGATIONAL NEW DRUGS

Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser863and Multisite Phosphorylation

(2009) Kathryn G. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Rapamycin-Sensitive Signaling Pathway Is Essential for the Full Expression of Persistent Pain States

(2009) S. M. Geranton et al.   JOURNAL OF NEUROSCIENCE

mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling

(2009) L.-A. Julien et al.   MOLECULAR AND CELLULAR BIOLOGY

Increased Peripheral Nerve Excitability and Local Nav1.8 RNA Up-Regulation in Painful Neuropathy

(2009) Devang Kashyap Thakor et al.   Molecular Pain

Formalin-Induced Behavioural Hypersensitivity and Neuronal Hyperexcitability are Mediated by Rapid Protein Synthesis at the Spinal Level

(2009) Curtis O Asante et al.   Molecular Pain

AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply

(2009) S. Hoppe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sympathetic Dystrophy Associated With Sirolimus Therapy

(2009) Miguel Gonzalez Molina et al.   TRANSPLANTATION

Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas

(2008) Joel A. Black et al.   ANNALS OF NEUROLOGY

Oxidative stress induces PKR-dependent apoptosis via IFN-γ activation signaling in Jurkat T cells

(2008) Chul-Woong Pyo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Cytoprotective mechanisms of carbonyl scavenging drugs in isolated rat hepatocytes

(2008) Rhea Mehta et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A chemical compound commonly used to inhibit PKR, {8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one}, protects neurons by inhibiting cyclin-dependent kinase

(2008) Hsin-Mei Chen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)

(2008) Maria Buxade   Frontiers in Bioscience-Landmark

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

(2008) Arkaitz Carracedo et al.   JOURNAL OF CLINICAL INVESTIGATION

Schwann Cell to Axon Transfer of Ribosomes: Toward a Novel Understanding of the Role of Glia in the Nervous System

(2008) F. A. Court et al.   JOURNAL OF NEUROSCIENCE

Control of Cellular GADD34 Levels by the 26S Proteasome

(2008) M. H. Brush et al.   MOLECULAR AND CELLULAR BIOLOGY

Poly(A)-Binding Protein-Interacting Protein 1 Binds to Eukaryotic Translation Initiation Factor 3 To Stimulate Translation

(2008) Y. Martineau et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Activation of Erk in the Anterior Cingulate Cortex During the Induction and Expression of Chronic Pain

(2008) Feng Wei et al.   Molecular Pain

Local Translation in Primary Afferent Fibers Regulates Nociception

(2008) Lydia Jiménez-Díaz et al.   PLoS One