Opioid receptor–triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia

Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis

(2013) Francesco Ferrini et al.   NATURE NEUROSCIENCE

A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons

(2013) Xiuli Zhao et al.   NATURE NEUROSCIENCE

Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance

(2013) Joshua W. Little et al.   PAIN

Spinal Cord NMDA Receptor-Mediated Activation of Mammalian Target of Rapamycin Is Required for the Development and Maintenance of Bone Cancer-Induced Pain Hypersensitivities in Rats

(2012) Ming-Hung Shih et al.   JOURNAL OF PAIN

Absence of μ opioid receptor mRNA expression in astrocytes and microglia of rat spinal cord

(2012) Sheng-Chin Kao et al.   NEUROREPORT

5-Hydroxytryptamine Type 3 Receptor Modulates Opioid-induced Hyperalgesia and Tolerance in Mice

(2011) De-Yong Liang et al.   ANESTHESIOLOGY

Pancreatic Tumor Suppression by Benzyl Isothiocyanate Is Associated with Inhibition of PI3K/AKT/FOXO Pathway

(2011) S. R. Boreddy et al.   CLINICAL CANCER RESEARCH

mTOR as a therapeutic target in patients with gastric cancer

(2011) Salah-Eddin Al-Batran et al.   INTERNATIONAL JOURNAL OF CANCER

Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-κB pathways in monocytes/macrophages

(2011) Young-Jun Shim et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Spinal Phosphinositide 3-Kinase-Akt-Mammalian Target of Rapamycin Signaling Cascades in Inflammation-Induced Hyperalgesia

(2011) Q. Xu et al.   JOURNAL OF NEUROSCIENCE

Opioid-Induced Hyperalgesia and Tolerance

(2010) Mary Hanna Bekhit   AMERICAN JOURNAL OF THERAPEUTICS

Expression and distribution of mTOR, p70S6K, 4E-BP1, and their phosphorylated counterparts in rat dorsal root ganglion and spinal cord dorsal horn

(2010) Ji-Tain Xu et al.   BRAIN RESEARCH

Mechanisms underlying morphine analgesic tolerance and dependence

(2010) Hiroshi Ueda   Frontiers in Bioscience-Landmark

Involvement of Spinal Microglial P2X7 Receptor in Generation of Tolerance to Morphine Analgesia in Rats

(2010) D. Zhou et al.   JOURNAL OF NEUROSCIENCE

Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behavior

(2010) Jeong Il Choi et al.   PAIN

Making synaptic plasticity and memory last: mechanisms of translational regulation

(2009) J. D. Richter et al.   GENES & DEVELOPMENT

Morphine Enhances Microglial Migration through Modulation of P2X4 Receptor Signaling

(2009) R. J. Horvath et al.   JOURNAL OF NEUROSCIENCE

A Rapamycin-Sensitive Signaling Pathway Is Essential for the Full Expression of Persistent Pain States

(2009) S. M. Geranton et al.   JOURNAL OF NEUROSCIENCE

Translational Control of Long-Lasting Synaptic Plasticity and Memory

(2009) Mauro Costa-Mattioli et al.   NEURON

Expression of p-Akt in Sensory Neurons and Spinal Cord after Peripheral Nerve Injury

(2009) Tie-Jun Sten Shi et al.   NEUROSIGNALS

Activation of TRPV1 Contributes to Morphine Tolerance: Involvement of the Mitogen-Activated Protein Kinase Signaling Pathway

(2008) Y. Chen et al.   JOURNAL OF NEUROSCIENCE

Distinct Expression of Synaptic NR2A and NR2B in the Central Nervous System and Impaired Morphine Tolerance and Physical Dependence in Mice Deficient in Postsynaptic Density-93 Protein

(2008) Wen-Jinn Liaw et al.   Molecular Pain

Kidney Transplant Histology After One Year of Continuous Therapy With Sirolimus Compared With Tacrolimus

(2008) Patrick G. Dean et al.   TRANSPLANTATION