PERK-Dependent Activation of JAK1 and STAT3 Contributes to Endoplasmic Reticulum Stress-Induced Inflammation

KDEL-Retained Antigen in B Lymphocytes Induces a Proinflammatory Response: A Possible Role for Endoplasmic Reticulum Stress in Adaptive T Cell Immunity

(2014) M. C. Wheeler et al.   JOURNAL OF IMMUNOLOGY

Activating Transcription Factor 4 Links Metabolic Stress to Interleukin-6 Expression in Macrophages

(2013) Y. Iwasaki et al.   DIABETES

Roles of STAT3 in Protein Secretion Pathways during the Acute-Phase Response

(2013) Ayele-Nati N. Ahyi et al.   INFECTION AND IMMUNITY

Oligodendrocyte-Specific Activation of PERK Signaling Protects Mice against Experimental Autoimmune Encephalomyelitis

(2013) W. Lin et al.   JOURNAL OF NEUROSCIENCE

NF-κB-Induced IL-6 Ensures STAT3 Activation and Tumor Aggressiveness in Glioblastoma

(2013) Braden C. McFarland et al.   PLoS One

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

(2013) J. A. Moreno et al.   Science Translational Medicine

ER stress upregulated PGE2/IFNγ-induced IL-6 expression and down-regulated iNOS expression in glial cells

(2013) Toru Hosoi et al.   Scientific Reports

The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway

(2012) Y. Wang et al.   CANCER RESEARCH

The Role of ER Stress-Induced Apoptosis in Neurodegeneration

(2012) Ioanna C. Stefani et al.   Current Alzheimer Research

Regulation of CCL20 expression in astrocytes by IL-6 and IL-17

(2012) Gordon P. Meares et al.   GLIA

JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

(2012) John J. O'Shea et al.   IMMUNITY

Interleukin-6, a Major Cytokine in the Central Nervous System

(2012) María Erta et al.   International Journal of Biological Sciences

AMP-Activated Protein Kinase Restricts IFN-  Signaling

(2012) G. P. Meares et al.   JOURNAL OF IMMUNOLOGY

Endoplasmic Reticulum Stress Regulates the Innate Immunity Critical Transcription Factor IRF3

(2012) Yi-Ping Liu et al.   JOURNAL OF IMMUNOLOGY

Endoplasmic reticulum dysfunction in neurological disease

(2012) Benoit D Roussel et al.   LANCET NEUROLOGY

Cytoplasmic STAT3 Represses Autophagy by Inhibiting PKR Activity

(2012) Shensi Shen et al.   MOLECULAR CELL

Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation

(2012) H. Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TH17 cytokines in autoimmune neuro-inflammation

(2011) Burkhard Becher et al.   CURRENT OPINION IN IMMUNOLOGY

Glycogen synthase kinase-3 regulates endoplasmic reticulum (ER) stress-induced CHOP expression in neuronal cells

(2011) Gordon P. Meares et al.   EXPERIMENTAL CELL RESEARCH

Neuroinflammation and Endoplasmic Reticulum Stress Are Coregulated by Crocin To Prevent Demyelination and Neurodegeneration

(2011) A. M. Deslauriers et al.   JOURNAL OF IMMUNOLOGY

The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies

(2011) Diana AT Nijholt et al.   JOURNAL OF PATHOLOGY

Therapeutic Potential of AZD1480 for the Treatment of Human Glioblastoma

(2011) B. C. McFarland et al.   MOLECULAR CANCER THERAPEUTICS

Expression profiles of endoplasmic reticulum stress-related molecules in demyelinating lesions and multiple sclerosis

(2011) Paula Cunnea et al.   Multiple Sclerosis Journal

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

NF-κB and STAT3 cooperatively induce IL6 in starved cancer cells

(2011) S Yoon et al.   ONCOGENE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Oncostatin M up-regulates the ER chaperone Grp78/BiP in liver cells

(2010) Stefan Vollmer et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum

(2010) Fabio Martinon et al.   CURRENT OPINION IN IMMUNOLOGY

IL-17 Enhancement of the IL-6 Signaling Cascade in Astrocytes

(2010) X. Ma et al.   JOURNAL OF IMMUNOLOGY

Discovery of 5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a Novel Inhibitor of the Jak/Stat Pathway

(2010) Stephanos Ioannidis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanism of ER Stress-Induced Brain Damage by IP3 Receptor

(2010) Takayasu Higo et al.   NEURON

Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression

(2010) Jane C. Goodall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

(2009) Michael Hedvat et al.   CANCER CELL

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

(2009) Sergei I. Grivennikov et al.   CYTOKINE & GROWTH FACTOR REVIEWS

ERp57 Modulates STAT3 Signaling from the Lumen of the Endoplasmic Reticulum

(2009) Helen Coe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Expression of Endoplasmic Reticulum Stress-Related Signaling Pathway Molecules in Multiple Sclerosis Lesions

(2009) Aoife Ní Mháille et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Involvement of CHOP, an ER-stress apoptotic mediator, in both human sporadic ALS and ALS model mice

(2009) Yasushi Ito et al.   NEUROBIOLOGY OF DISEASE

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE