Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors

PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz

(2017) Ana Crespillo-Casado et al.   eLife

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

(2016) Ying-Nan P. Chen et al.   NATURE

Surviving protein quality control catastrophes - from cells to organisms

(2015) K. Schneider et al.   JOURNAL OF CELL SCIENCE

An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α

(2015) Margarito Rojas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

(2015) I. Das et al.   SCIENCE

Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase

(2015) Meng S. Choy et al.   Cell Reports

Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction

(2014) Aidan G Gilmartin et al.   Nature Chemical Biology

Targeting the disordered C terminus of PTP1B with an allosteric inhibitor

(2014) Navasona Krishnan et al.   Nature Chemical Biology

Advances in kinase targeting: current clinical use and clinical trials

(2014) Mathias Rask-Andersen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

An enhanced integrated stress response ameliorates mutant SOD1-induced ALS

(2013) L. Wang et al.   HUMAN MOLECULAR GENETICS

Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice

(2013) Maurizio D’Antonio et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Challenges and Opportunities in the Development of Protein Phosphatase-Directed Therapeutics

(2012) Sofie De Munter et al.   ACS Chemical Biology

Exploiting the selectivity of protein phosphatase 1 for pharmacological intervention

(2012) Pavel Tsaytler et al.   FEBS Journal

Structural basis for protein phosphatase 1 regulation and specificity

(2012) Wolfgang Peti et al.   FEBS Journal

Protein Ser/ Thr phosphatases - the ugly ducklings of cell signalling

(2012) David L. Brautigan   FEBS Journal

The PP1 binding code: a molecular-lego strategy that governs specificity

(2012) Ewald Heroes et al.   FEBS Journal

Protein tyrosine phosphatases - from housekeeping enzymes to master regulators of signal transduction

(2012) Nicholas K. Tonks   FEBS Journal

Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition

(2012) R. Wilcken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

(2011) P. Tsaytler et al.   SCIENCE

Docking Motif-Guided Mapping of the Interactome of Protein Phosphatase-1

(2009) Annick Hendrickx et al.   CHEMISTRY & BIOLOGY

From Promiscuity to Precision: Protein Phosphatases Get a Makeover

(2009) David M. Virshup et al.   MOLECULAR CELL

Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development

(2009) Heather P. Harding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cracking the Phosphatase Code: Docking Interactions Determine Substrate Specificity

(2009) J. Roy et al.   Science Signaling

Ablation of the UPR-Mediator CHOP Restores Motor Function and Reduces Demyelination in Charcot-Marie-Tooth 1B Mice

(2008) Maria Pennuto et al.   NEURON

Antihypertensive Drug Guanabenz Is Active In Vivo against both Yeast and Mammalian Prions

(2008) Déborah Tribouillard-Tanvier et al.   PLoS One

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE