The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors

PERK inhibition attenuates the abnormalities of the secretory pathway and the increased apoptotic rate induced by SIL1 knockdown in HeLa cells

(2018) Vanessa Capone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PERK Regulates Glioblastoma Sensitivity to ER Stress While Promoting Radiation Resistance

(2018) David YA Dadey et al.   MOLECULAR CANCER RESEARCH

Effects of PERK eIF2α kinase inhibitor against Toxoplasma gondii

(2018) Leonardo Augusto et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The EGFR odyssey – from activation to destruction in space and time

(2017) Jeroen Bakker et al.   JOURNAL OF CELL SCIENCE

Molecular and functional characterization of a new 3′ end KIT juxtamembrane deletion in a duodenal GIST treated with neoadjuvant Imatinib

(2017) Vittorio Perfetti et al.   Oncotarget

Targeting c-KIT (CD117) by dasatinib and radotinib promotes acute myeloid leukemia cell death

(2017) Sook-Kyoung Heo et al.   Scientific Reports

An unfolded protein-induced conformational switch activates mammalian IRE1

(2017) G Elif Karagöz et al.   eLife

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma

(2016) Dariusz Pytel et al.   PLoS Genetics

C-kit mutations determine dasatinib mechanism of action in HMC-1 neoplastic mast cells: dasatinib differently regulates PKCδtranslocation in HMC-1560and HMC-1560,816cell lines

(2015) Araceli Tobío et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Discovery of 1H-Pyrazol-3(2H)-ones as Potent and Selective Inhibitors of Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK)

(2015) Adrian L. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

(2015) M Halliday et al.   Cell Death & Disease

Long-term outcome with dasatinib after imatinib failure in chronic-phase chronic myeloid leukemia: follow-up of a phase 3 study

(2014) N. P. Shah et al.   BLOOD

Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

(2014) Rajarshi Ghosh et al.   CELL

C-KIT Signaling in Cancer Treatment

(2014) Karmen Stankov et al.   CURRENT PHARMACEUTICAL DESIGN

Synthesis of Novel Tricyclic Chromenone-Based Inhibitors of IRE-1 RNase Activity

(2014) Sujeewa Ranatunga et al.   JOURNAL OF MEDICINAL CHEMISTRY

Clathrin Assembly Protein CALM Plays a Critical Role in KIT Signaling by Regulating Its Cellular Transport from Early to Late Endosomes in Hematopoietic Cells

(2014) Shinya Rai et al.   PLoS One

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor

(2013) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

(2012) Jeffrey M. Axten et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of a pivotal endocytosis motif in c-Met and selective modulation of HGF-dependent aggressiveness of cancer using the 16-mer endocytic peptide

(2012) K-W Cho et al.   ONCOGENE

Intracellular Retention of ABL Kinase Inhibitors Determines Commitment to Apoptosis in CML Cells

(2012) Daniel B. Lipka et al.   PLoS One

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Met Receptor: A Moving Target

(2011) M. J. Clague   Science Signaling

Agonist-induced internalization and downregulation of gonadotropin-releasing hormone receptors

(2009) Ann R. Finch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY