Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis

Crosstalks between translation and metabolism in cancer

(2018) Stefano Biffo et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Structure-based Design of Pyridone–Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition

(2018) Siegfried H. Reich et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold

(2018) Xin Jin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

mTOR as a central hub of nutrient signalling and cell growth

(2018) Joungmok Kim et al.   NATURE CELL BIOLOGY

Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment

(2018) Maxim Mogilevsky et al.   NUCLEIC ACIDS RESEARCH

mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation

(2017) Stephen Fitter et al.   MOLECULAR AND CELLULAR BIOLOGY

The androgen receptor is a negative regulator of eIF4E phosphorylation at S209: implications for the use of mTOR inhibitors in advanced prostate cancer

(2017) L S D'Abronzo et al.   ONCOGENE

MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1

(2017) Michael C. Brown et al.   Cell Reports

Tuning Specific Translation in Cancer Metastasis and Synaptic Memory: Control at the MNK–eIF4E Axis

(2016) Clive R. Bramham et al.   TRENDS IN BIOCHEMICAL SCIENCES

The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding

(2015) James E. Beggs et al.   BIOCHEMICAL JOURNAL

Mnks, eIF4E phosphorylation and cancer

(2015) Christopher G. Proud   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Molecular Mechanism for the Control of Eukaryotic Elongation Factor 2 Kinase by pH: Role in Cancer Cell Survival

(2015) Jianling Xie et al.   MOLECULAR AND CELLULAR BIOLOGY

Brief Report: The Differential Roles of mTORC1 and mTORC2 in Mesenchymal Stem Cell Differentiation

(2015) Sally K. Martin et al.   STEM CELLS

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells

(2015) Frank Eckerdt et al.   Oncotarget

MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas

(2014) Michal Grzmil et al.   JOURNAL OF CLINICAL INVESTIGATION

Exendin-4 stimulates islet cell replication via the IGF1 receptor activation of mTORC1/S6K1

(2014) J. Xie et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Eukaryotic Elongation Factor 2 Kinase Activity Is Controlled by Multiple Inputs from Oncogenic Signaling

(2014) X. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting RAS–ERK signalling in cancer: promises and challenges

(2014) Ahmed A. Samatar et al.   NATURE REVIEWS DRUG DISCOVERY

Renal tumours in a Tsc2+/− mouse model do not show feedback inhibition of Akt and are effectively prevented by rapamycin

(2014) J Yang et al.   ONCOGENE

Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3

(2014) N Robichaud et al.   ONCOGENE

Mnk2 Alternative Splicing Modulates the p38-MAPK Pathway and Impacts Ras-Induced Transformation

(2014) Avraham Maimon et al.   Cell Reports

Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014

(2013) Kurt G. Pike et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a)

(2013) Rebecca L. Stead et al.   FEBS LETTERS

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

(2013) S. A. Kang et al.   SCIENCE

Stable isotope-labelling analysis of the impact of inhibition of the mammalian target of rapamycin on protein synthesis

(2012) Yilin Huo et al.   BIOCHEMICAL JOURNAL

Evidence for Efficacy of New Hsp90 Inhibitors Revealed by Ex Vivo Culture of Human Prostate Tumors

(2012) M. M. Centenera et al.   CLINICAL CANCER RESEARCH

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Insights into the regulation of eukaryotic elongation factor 2 kinase and the interplay between its domains

(2011) Craig R. Pigott et al.   BIOCHEMICAL JOURNAL

cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity

(2011) Jianling Xie et al.   CELLULAR SIGNALLING

Discovery of 9-(6-Aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a Potent, Selective, and Orally Available Mammalian Target of Rapamycin (mTOR) Inhibitor for Treatment of Cancer

(2011) Qingsong Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Simultaneous Inhibition of mTOR-Containing Complex 1 (mTORC1) and MNK Induces Apoptosis of Cutaneous T-Cell Lymphoma (CTCL) Cells

(2011) Michal Marzec et al.   PLoS One

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

Epigenetic regulator MLL2 shows altered expression in cancer cell lines and tumors from human breast and colon

(2010) Thanemozhi G Natarajan et al.   Cancer Cell International

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

(2010) L. Furic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells

(2010) Nathalie Carayol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity

(2009) C. M. Chresta et al.   CANCER RESEARCH

Identification of cAMP-Dependent Kinase as a Third in Vivo Ribosomal Protein S6 Kinase in Pancreatic β-Cells

(2009) Claire E.J. Moore et al.   JOURNAL OF MOLECULAR BIOLOGY

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)

(2008) Maria Buxade   Frontiers in Bioscience-Landmark

Regulation of Proline-rich Akt Substrate of 40 kDa (PRAS40) Function by Mammalian Target of Rapamycin Complex 1 (mTORC1)-mediated Phosphorylation

(2008) Lifu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Multicolor Panel of Novel Lentiviral “Gene Ontology” (LeGO) Vectors for Functional Gene Analysis

(2008) Kristoffer Weber et al.   MOLECULAR THERAPY