Mutations in a translation initiation factor identify the target of a memory-enhancing compound

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

(2015) Carmela Sidrauski et al.   eLife

Insights into the Architecture of the eIF2Bα/β/δ Regulatory Subcomplex

(2014) Andrew M. Bogorad et al.   BIOCHEMISTRY

Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool

(2014) Carlotta Ronda et al.   BIOTECHNOLOGY AND BIOENGINEERING

Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation

(2014) Noel C. Wortham et al.   FASEB JOURNAL

Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α

(2014) Gonzalo Viana Di Prisco et al.   NATURE NEUROSCIENCE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases

(2012) Xun Shang et al.   CHEMISTRY & BIOLOGY

Uncoupling Proteostasis and Developmentin Vitrowith a Small Molecule Inhibitor of the Pancreatic Endoplasmic Reticulum Kinase, PERK

(2012) Heather P. Harding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

(2012) Jeffrey M. Axten et al.   JOURNAL OF MEDICINAL CHEMISTRY

Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism

(2012) Thomas D. Baird et al.   Advances in Nutrition

Interaction of Mycobacterium tuberculosis Elongation Factor Tu with GTP Is Regulated by Phosphorylation

(2011) A. Sajid et al.   JOURNAL OF BACTERIOLOGY

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS