Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors
Authors
Keywords
-
Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 24, Issue 9, Pages 708-716
Publisher
Springer Nature
Online
2017-07-31
DOI
10.1038/nsmb.3443
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz
- (2017) Ana Crespillo-Casado et al. eLife
- Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
- (2016) Ying-Nan P. Chen et al. NATURE
- Surviving protein quality control catastrophes - from cells to organisms
- (2015) K. Schneider et al. JOURNAL OF CELL SCIENCE
- An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α
- (2015) Margarito Rojas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit
- (2015) I. Das et al. SCIENCE
- Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase
- (2015) Meng S. Choy et al. Cell Reports
- Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction
- (2014) Aidan G Gilmartin et al. Nature Chemical Biology
- Targeting the disordered C terminus of PTP1B with an allosteric inhibitor
- (2014) Navasona Krishnan et al. Nature Chemical Biology
- Advances in kinase targeting: current clinical use and clinical trials
- (2014) Mathias Rask-Andersen et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- An enhanced integrated stress response ameliorates mutant SOD1-induced ALS
- (2013) L. Wang et al. HUMAN MOLECULAR GENETICS
- Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice
- (2013) Maurizio D’Antonio et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Challenges and Opportunities in the Development of Protein Phosphatase-Directed Therapeutics
- (2012) Sofie De Munter et al. ACS Chemical Biology
- Exploiting the selectivity of protein phosphatase 1 for pharmacological intervention
- (2012) Pavel Tsaytler et al. FEBS Journal
- Structural basis for protein phosphatase 1 regulation and specificity
- (2012) Wolfgang Peti et al. FEBS Journal
- Protein Ser/ Thr phosphatases - the ugly ducklings of cell signalling
- (2012) David L. Brautigan FEBS Journal
- The PP1 binding code: a molecular-lego strategy that governs specificity
- (2012) Ewald Heroes et al. FEBS Journal
- Protein tyrosine phosphatases - from housekeeping enzymes to master regulators of signal transduction
- (2012) Nicholas K. Tonks FEBS Journal
- Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition
- (2012) R. Wilcken et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis
- (2011) P. Tsaytler et al. SCIENCE
- Docking Motif-Guided Mapping of the Interactome of Protein Phosphatase-1
- (2009) Annick Hendrickx et al. CHEMISTRY & BIOLOGY
- From Promiscuity to Precision: Protein Phosphatases Get a Makeover
- (2009) David M. Virshup et al. MOLECULAR CELL
- Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development
- (2009) Heather P. Harding et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cracking the Phosphatase Code: Docking Interactions Determine Substrate Specificity
- (2009) J. Roy et al. Science Signaling
- Ablation of the UPR-Mediator CHOP Restores Motor Function and Reduces Demyelination in Charcot-Marie-Tooth 1B Mice
- (2008) Maria Pennuto et al. NEURON
- Antihypertensive Drug Guanabenz Is Active In Vivo against both Yeast and Mammalian Prions
- (2008) Déborah Tribouillard-Tanvier et al. PLoS One
- Adapting Proteostasis for Disease Intervention
- (2008) William E. Balch et al. SCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search