Article
Biochemistry & Molecular Biology
Milena Sleczkowska, Rowida Almomani, Margherita Marchi, Erika Salvi, Bianca T. A. de Greef, Maurice Sopacua, Janneke G. J. Hoeijmakers, Patrick Lindsey, Stephen G. Waxman, Giuseppe Lauria, Catharina G. Faber, Hubert J. M. Smeets, Monique M. Gerrits
Summary: This study assessed the role of fifteen ion channel genes in neuropathic pain. Variants in ion channel genes were identified in SFN patients, with TRP genes being the most frequent. Patients with these variants reported more severe pain. This study provides promising gene candidates for future research on neuropathic pain etiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Jackie Elliott, Gordon Sloan, Lynda Stevens, Dinesh Selvarajah, Giorgio Cruccu, Rajiv A. Gandhi, Peter Kempler, John H. Fuller, Nishi Chaturvedi, Solomon Tesfaye
Summary: This study analyzed the EURODIAB Prospective Complications Study data to investigate the incidence and risk factors of painful DPN. It found that female sex was a risk factor for painful DPN and there was less evidence of diabetic nephropathy in painful DPN cases.
Article
Neurosciences
Laura Behrendt, Christian Hoischen, Christoph Kaether
Summary: Mutations in the ER-network forming GTPase atlastin3 (ATL3) can cause axon degeneration of sensory neurons. The mutated ATL3 is excluded from distal axons by a selective barrier at the axon initial segment. Actin-depolymerization partially restores the transport of mutated ATL3 into distal axons.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Milena Sleczkowska, Rowida Almomani, Margherita Marchi, Bianca T. A. de Greef, Maurice Sopacua, Janneke G. J. Hoeijmakers, Patrick Lindsey, Erika Salvi, Gidon J. Boenhof, Dan Ziegler, Rayaz A. Malik, Stephen G. Waxman, Giuseppe Lauria, Catharina G. Faber, Hubert J. M. Smeets, Monique M. Gerrits
Summary: Neuropathic pain is common in diabetic peripheral neuropathy (DN), and it may be caused by pathogenic ion channel gene variants. Variants in ion channel genes were found in DN patients with and without pain, suggesting their role in pain generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
Lian Jingxuan, Ma Litian, Fu Jianfang
Summary: The study found that drugs like pregabalin and duloxetine have significant pain relief effects on painful diabetic peripheral neuropathy, but with significant adverse events. Meanwhile, ABT-894 and gabapentin showed unclear effects, and drugs like buprenorphine and tanezumab require further research.
FRONTIERS IN NEUROLOGY
(2021)
Article
Cell Biology
Zizhen Wu, Gabor Toro, Guoying Xu, Danny Dang, Charmaine Prater, Qing Yang
Summary: Paclitaxel-induced peripheral neuropathy (PIPN), a common complication in cancer patients undergoing paclitaxel treatment, has no effective therapy currently available. The study found that acute hyperexcitability of primary sensory neurons in PIPN is caused by the inhibition of KCNQ2 potassium channels by paclitaxel. Further experiments demonstrated that administration of KCNQ channel blocker XE-991 induced PIPN-like alterations in rats, while genetic deletion of KCNQ2 in mice attenuated the development of PIPN. These findings provide insights into the pathogenesis of PIPN and may lead to the development of new therapeutic approaches targeting KCNQ channels.
Review
Neurosciences
Th. Hornemann
Summary: Neurons are polarized cells responsible for receiving, conducting, and transmitting signals. The peripheral nervous system serves as a relay between the central nervous system and limbs/organs, and is vulnerable to genetic, metabolic, and environmental factors. Lipids play a crucial role in nerves, but their involvement in peripheral nervous system disorders is not well understood.
NEUROSCIENCE LETTERS
(2021)
Review
Clinical Neurology
Josianna Henson, Narayana C. Varhabhatla, Zvonimir Bebic, Alan D. Kaye, R. Jason Yong, Richard D. Urman, Justin S. Merkow
Summary: Painful diabetic neuropathy is a common disease causing significant pain and disability. Spinal cord stimulation has shown moderate-quality evidence for safety and efficacy in treating this condition. Further high-quality research, including large-scale randomized controlled trials, is needed to confirm its effectiveness.
Article
Clinical Neurology
Alaa A. Abd-Elsayed, Lizandra P. Marcondes, Zachary B. Loris, Daniel Reilly
Summary: An online survey was conducted in the USA to obtain information about the knowledge and experiences of patients with painful diabetic peripheral neuropathy (pDPN). The results showed that patients have a good understanding of their pain and trust their doctors, but they are unsatisfied with their current treatment and struggle to find a lasting solution for their pain. Early identification and diagnosis of pain in diabetics, and education about treatments, is important to minimize the impact of pain on quality of life and emotional well-being.
JOURNAL OF PAIN RESEARCH
(2023)
Review
Endocrinology & Metabolism
Frank G. Preston, David R. Riley, Shazli Azmi, Uazman Alam
Summary: Painful diabetic peripheral neuropathy (PDPN) affects a significant number of people with diabetes and has a negative impact on their daily functioning and quality of life. Despite its prevalence, it is often underdiagnosed and undertreated. PDPN is a complex pain phenomenon that is associated with sleep disturbances and low mood. It requires a holistic approach to treatment, along with pharmacological therapy.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Review
Medicine, General & Internal
Jamie Burgess, Bernhard Frank, Andrew Marshall, Rashaad S. Khalil, Georgios Ponirakis, Ioannis N. Petropoulos, Daniel J. Cuthbertson, Rayaz A. Malik, Uazman Alam
Summary: Diabetic peripheral neuropathy is a common complication of diabetes that significantly impacts quality of life and healthcare burden. Current screening methods for early detection of DPN have limitations, highlighting the need for further research and clinical practices to improve accuracy and early detection.
Review
Clinical Neurology
Luolin Zhou, Tong Wu, Zhishan Zhong, Lichen Yi, Yuemei Li
Summary: This systematic review and meta-analysis evaluated the efficacy and safety of acupuncture in combination with conventional treatment for pain relief in patients with diabetic peripheral neuropathy. The results showed that acupuncture therapy combined with conventional treatment was more effective in improving pain compared to conventional treatment alone, especially when acupoints were located in the limbs.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Felix Javier Jimenez-Jimenez, Hortensia Alonso-Navarro, Elena Garcia-Martin, Jose A. G. Agundez
Summary: The coexistence of peripheral neuropathy (PN) and restless legs syndrome (RLS) is relatively frequent, with RLS reported in 5.2%-53.7% of PN patients, and PN reported in 0%-87.5% of RLS patients, both significantly higher than controls. Variability across studies may be due to differences in diagnostic criteria. RLS is a common clinical complaint in patients with PN of different etiologies.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
Erika A. Petersen, Thomas G. Stauss, James A. Scowcroft, Michael J. Jaasma, Elizabeth S. Brooks, Deborah R. Edgar, Judith L. White, Shawn M. Sills, Kasra Amirdelfan, Maged N. Guirguis, Jijun Xu, Cong Yu, Ali Nairizi, Denis G. Patterson, Kostandinos C. Tsoulfas, Michael J. Creamer, Vincent Galan, Richard H. Bundschu, Neel D. Mehta, Dawood Sayed, Shivanand P. Lad, David J. Dibenedetto, Khalid A. Sethi, Johnathan H. Goree, Matthew T. Bennett, Nathan J. Harrison, Atef F. Israelc, Paul Chang, Paul W. Wu, Charles E. Argoff, Christian E. Nasr, Rod S. Taylor, David L. Caraway, Nagy A. Mekhail
Summary: A study evaluated the long-term efficacy of high-frequency (10 kHz) spinal cord stimulation (SCS) in treating refractory painful diabetic neuropathy (PDN). The results showed that over 24 months, 10 kHz SCS provided significant pain relief, improved quality of life and sleep, and showed neurological improvement in the majority of participants.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Chenxi Li, Weimin Wang, Qiuhe Ji, Xingwu Ran, Hongyu Kuang, Xuefeng Yu, Hui Fang, Jing Yang, Jing Liu, Yaoming Xue, Bo Feng, Minxiang Lei, Dalong Zhu
Summary: This study aimed to investigate the prevalence and risk factors of painful diabetic peripheral neuropathy (PDPN) in mainland China among patients with type 2 diabetes mellitus (T2DM) and diabetic peripheral neuropathy (DPN). A nationwide cross-sectional study was conducted, involving T2DM patients with DPN from 25 provinces in China. The study found that over half of the patients with DPN in mainland China had PDPN. Various factors such as age, education level, duration of diabetes, cholesterol levels, and comorbidities were independently associated with PDPN.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Urology & Nephrology
William S. Chen, Rahul Aggarwal, Li Zhang, Shuang G. Zhao, George Thomas, Tomasz M. Beer, David A. Quigley, Adam Foye, Denise Playdle, Jiaoti Huang, Paul Lloyd, Eric Lu, Duanchen Sun, Xiangnan Guan, Matthew Rettig, Martin Gleave, Christopher P. Evans, Jack Youngren, Lawrence True, Primo N. Lara, Vishal Kothari, Zheng Xia, Kim N. Chi, Robert E. Reiter, Christopher A. Maher, Felix Y. Feng, Eric J. Small, Joshi J. Alumkal
Article
Biology
Guak-Kim Tan, Brian A. Pryce, Anna Stabio, John V. Brigande, ChaoJie Wang, Zheng Xia, Sara F. Tufa, Douglas R. Keene, Ronen Schweitzer
Article
Neurosciences
Vincent N. Marty, Yatendra Mulpuri, Joseph J. Munier, Igor Spigelman
Article
Multidisciplinary Sciences
Joshi J. Alumkal, Duanchen Sun, Eric Lu, Tomasz M. Beer, George V. Thomas, Emile Latour, Rahul Aggarwal, Jeremy Cetnar, Charles J. Ryan, Shaadi Tabatabaei, Shawna Bailey, Claire B. Turina, David A. Quigley, Xiangnan Guan, Adam Foye, Jack F. Youngren, Joshua Urrutia, Jiaoti Huang, Alana S. Weinstein, Verena Friedl, Matthew Rettig, Robert E. Reiter, Daniel E. Spratt, Martin Gleave, Christopher P. Evans, Joshua M. Stuart, Yiyi Chen, Felix Y. Feng, Eric J. Small, Owen N. Witte, Zheng Xia
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Oncology
Xiangnan Guan, Duanchen Sun, Eric Lu, Joshua A. Urrutia, Robert Evan Reiter, Matthew Rettig, Christopher P. Evans, Primo Lara, Martin Gleave, Tomasz M. Beer, George Thomas, Jiaoti Huang, Rahul R. Aggarwal, David A. Quigley, Adam Foye, William S. Chen, Jack Youngren, Alana S. Weinstein, Joshua M. Stuart, Felix Y. Feng, Eric J. Small, Zheng Xia, Joshi J. Alumkal
CLINICAL CANCER RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Diana C. Cox, Xiangnan Guan, Zheng Xia, Thomas A. Cooper
HUMAN MOLECULAR GENETICS
(2020)
Article
Oncology
Daniel J. Coleman, David A. Sampson, Archana Sehrawat, Anbarasu Kumaraswamy, Duanchen Sun, Yuzhuo Wang, Jacob Schwartzman, Joshua Urrutia, Ahn R. Lee, Ilsa M. Coleman, Peter S. Nelson, Xuesen Dong, Colm Morrissey, Eva Corey, Zheng Xia, Joel A. Yates, Joshi J. Alumkal
Article
Multidisciplinary Sciences
Honey Tavanasefat, Feng Li, Kikuye Koyano, Bahar Khalilian Gourtani, Vincent Marty, Yatendra Mulpuri, Sung Hee Lee, Ki-Hyuk Shin, David T. W. Wong, Xinshu Xiao, Igor Spigelman, Yong Kim
Article
Neurosciences
Vincent N. Marty, Mehdi Farokhnia, Joseph J. Munier, Yatendra Mulpuri, Lorenzo Leggio, Igor Spigelman
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Medicine, Research & Experimental
Ashish N. Rao, Hannah M. Campbell, Xiangnan Guan, Tarah A. Word, Xander H. T. Wehrens, Zheng Xia, Thomas A. Cooper
Summary: The study identified that cardiac involvement in DM1 patients is caused by the expression of CUG repeat expansion RNA, leading to symptoms such as cardiac conduction delays and arrhythmias, including changes in gene expression and alternative splicing of genes related to calcium channels. The phenotypes could be rescued upon elimination of CUG repeat expansion RNA expression.
Article
Anesthesiology
Toru Yamamoto, Yatendra Mulpuri, Mikhail Izraylev, Qianyi Li, Menooa Simonian, Christian Kramme, Brian L. Schmidt, Herbert H. Seltzman, Igor Spigelman
Summary: Migraine affects a significant portion of the global population, with current treatments only effective in a subset of patients. Peripherally restricted cannabinoids (PRCBs) show promise in alleviating chronic pain symptoms, offering a potential therapeutic target for migraine and medication overuse headache.
Article
Oncology
Dae-Hwan Kim, Duanchen Sun, William K. Storck, Katherine Welker Leng, Chelsea Jenkins, Daniel J. Coleman, David Sampson, Xiangnan Guan, Anbarasu Kumaraswamy, Eva S. Rodansky, Joshua A. Urrutia, Jacob A. Schwartzman, Chao Zhang, Himisha Beltran, Mark P. Labrecque, Colm Morrissey, Jared M. Lucas, Ilsa M. Coleman, Peter S. Nelson, Eva Corey, Samuel K. Handelman, Jonathan Z. Sexton, Rahul Aggarwal, Wassim Abida, Felix Y. Feng, Eric J. Small, Daniel E. Spratt, Armand Bankhead, Arvind Rao, Emily M. Gesner, Sarah Attwell, Sanjay Lakhotia, Eric Campeau, Joel A. Yates, Zheng Xia, Joshi J. Alumkal
Summary: NEPC is the most aggressive lineage plasticity in prostate cancer, with limited treatment options. By inhibiting AR and using BET inhibitors, it is possible to block this lineage plasticity, showing promising potential for t-NEPC treatment.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Tingting Liu, Vi Lam, Elana Thieme, Duanchen Sun, Xiaoguang Wang, Fei Xu, Lili Wang, Olga V. Danilova, Zheng Xia, Jeffrey W. Tyner, Stephen E. Kurtz, Alexey V. Danilov
Summary: AZD5991 targets Mcl-1 effectively in lymphoid malignancies and overcomes resistance. Inhibition of Mcl-1 results in mitochondrial dysfunction, with TP53 and oxidative phosphorylation playing crucial roles in resistance to Mcl-1 inhibition.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Erin J. Helms, Mark W. Berry, R. Crystal Chaw, Christopher C. DuFort, Duanchen Sun, M. Kathrina Onate, Chet Oon, Sohinee Bhattacharyya, Hannah Sanford-Crane, Wesley Horton, Jennifer M. Finan, Ariana Sattler, Rosemary Makar, David W. Dawson, Zheng Xia, Sunil R. Hingorani, Mara H. Sherman
Summary: This study reveals the origins and functions of distinct cancer-associated fibroblast (CAF) subtypes in pancreatic ductal adenocarcinoma (PDAC). It shows that the abundant and transcriptionally diverse CAF population in PDAC arises from pancreatic stellate cells (PSC), but only a minor subset is derived from PSCs. These PSC-derived CAFs have unique functions in shaping the PDAC microenvironment.
Article
Biochemistry & Molecular Biology
Qiuchen Guo, Duanchen Sun, Alexander S. Barrett, Sonali Jindal, Nathan D. Pennock, Matthew W. Conklin, Zheng Xia, Elizabeth Mitchell, Ravikant Samatham, Naomi Mirza, Steven Jacques, Sheila Weinmann, Virginia F. Borges, Kirk C. Hansen, Pepper J. Schedin
Summary: Mammographically-detected breast density has an impact on breast cancer risk and progression, and the presence of fibrillar collagen plays a crucial role in breast density. This study investigated the physiological factors influencing collagen production in the breast. Through the analysis of gene expression in female rats, the study revealed a triphasic pattern of collagen gene regulation and reproductive state-dependent composition. The findings were confirmed in human breast tissue from premenopausal women. The study also found a correlation between the collagen gene signature and poor progression-free survival in breast cancer patients. These findings contribute to a better understanding of normal breast function, the etiology of breast density, and breast cancer risk and outcomes.