Discoveries in structure and physiology of mechanically activated ion channels

Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms

(2020) Peng Jin et al.   Annual Review of Neuroscience

TACAN Is an Ion Channel Involved in Sensing Mechanical Pain

(2020) Lou Beaulieu-Laroche et al.   CELL

Inactivation Kinetics and Mechanical Gating of Piezo1 Ion Channels Depend on Subdomains within the Cap

(2020) Amanda H. Lewis et al.   Cell Reports

Interactions between the N- and C-termini of the mechanosensitive ion channel AtMSL10 are consistent with a three-step mechanism for activation

(2020) Debarati Basu et al.   JOURNAL OF EXPERIMENTAL BOTANY

TMIE Defines Pore and Gating Properties of the Mechanotransduction Channel of Mammalian Cochlear Hair Cells

(2020) Christopher L. Cunningham et al.   NEURON

A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel

(2020) Jie Geng et al.   NEURON

A common polymorphism in the mechanosensitive ion channel PIEZO1 is associated with protection from severe malaria in humans

(2020) Christian N. Nguetse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insights into a Plant Mechanosensitive Ion Channel MSL1

(2020) Yawen Li et al.   Cell Reports

TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration

(2020) Amrutha Patkunarajah et al.   eLife

The Mechanosensitive Ion Channel MSL10 Potentiates Responses to Cell Swelling in Arabidopsis Seedlings

(2020) Debarati Basu et al.   CURRENT BIOLOGY

Piezo1 is required for outflow tract and aortic valve development.

(2020) Adèle Faucherre et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

TRP Channels as Sensors of Chemically-Induced Changes in Cell Membrane Mechanical Properties

(2019) Justyna Startek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ultrastructural organization of NompC in the mechanoreceptive organelle of Drosophila campaniform mechanoreceptors

(2019) Landi Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration

(2019) Yuanquan Song et al.   NEURON

A multiscale model of mechanotransduction by the ankyrin chains of the NOMPC channel

(2019) David Argudo et al.   JOURNAL OF GENERAL PHYSIOLOGY

Interaction of the Mechanosensitive Channel, MscS, with the Membrane Bilayer through Lipid Intercalation into Grooves and Pockets

(2019) Tim Rasmussen et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the Mechanosensitive Channel MscS Embedded in the Membrane Bilayer

(2019) Tim Rasmussen et al.   JOURNAL OF MOLECULAR BIOLOGY

Cryo-EM structure of OSCA1.2 fromOryza sativaelucidates the mechanical basis of potential membrane hyperosmolality gating

(2019) Koustav Maity et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-guided examination of the mechanogating mechanism of PIEZO2

(2019) Francisco J. Taberner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mechanosensitive Piezo1 channel is required for bone formation

(2019) Weijia Sun et al.   eLife

Structure and mechanogating of the mammalian tactile channel PIEZO2

(2019) Li Wang et al.   NATURE

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

(2019) Angel G. Solis et al.   NATURE

Force-induced conformational changes in PIEZO1

(2019) Yi-Chih Lin et al.   NATURE

Mechanically activated piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis

(2019) Anne-Laure Duchemin et al.   eLife

Heterozygous Variants in the Mechanosensitive Ion Channel TMEM63A Result in Transient Hypomyelination during Infancy

(2019) Huifang Yan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels

(2019) Dominique Douguet et al.   CELL

Mammalian TRP ion channels are insensitive to membrane stretch

(2019) Yury A. Nikolaev et al.   JOURNAL OF CELL SCIENCE

TMC1 and TMC2 Proteins Are Pore-Forming Subunits of Mechanosensitive Ion Channels

(2019) Yanyan Jia et al.   NEURON

Biophysical Principles of Ion-Channel-Mediated Mechanosensory Transduction

(2019) Charles D. Cox et al.   Cell Reports

Stimulation of Piezo1 by mechanical signals promotes bone anabolism

(2019) Xuehua Li et al.   eLife

The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier

(2019) Stephen G Brohawn et al.   eLife

Shear force sensing of epithelial Na+channel (ENaC) relies onN-glycosylated asparagines in the palm and knuckle domains of αENaC

(2019) Fenja Knoepp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS

(2019) Bharat Reddy et al.   eLife

Bacterial Mechanosensors

(2018) Charles D. Cox et al.   Annual Review of Physiology

Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation

(2018) Elizabeth L Evans et al.   BRITISH JOURNAL OF PHARMACOLOGY

Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection

(2018) Shang Ma et al.   CELL

GPR68 Senses Flow and Is Essential for Vascular Physiology

(2018) Jie Xu et al.   CELL

“Force-from-lipids” gating of mechanosensitive channels modulated by PUFAs

(2018) Pietro Ridone et al.   Journal of the Mechanical Behavior of Biomedical Materials

Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel

(2018) Li He et al.   NATURE

Structure and mechanogating mechanism of the Piezo1 channel

(2018) Qiancheng Zhao et al.   NATURE

Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms

(2018) Zengqin Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1

(2018) Jerome J. Lacroix et al.   Nature Communications

Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms

(2018) Zengqin Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the mechanosensitive OSCA channels

(2018) Mingfeng Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells

(2018) Bifeng Pan et al.   NEURON

Molecular Structure of the Hair Cell Mechanoelectrical Transduction Complex

(2018) Christopher L. Cunningham et al.   Cold Spring Harbor Perspectives in Medicine

Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins

(2018) Angela Ballesteros et al.   eLife

Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5

(2018) Jingpeng Ge et al.   eLife

Structure of the human epithelial sodium channel by cryo-electron microscopy

(2018) Sigrid Noreng et al.   eLife

Piezo1 mediates angiogenesis through activation of MT1-MMP signaling

(2018) Hojin Kang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression

(2018) Xin Chen et al.   NEURON

Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation

(2018) Keiko Nonomura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex

(2018) Wei-Zheng Zeng et al.   SCIENCE

PIEZO2 mediates injury-induced tactile pain in mice and humans

(2018) Marcin Szczot et al.   Science Translational Medicine

The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice

(2018) Swetha E. Murthy et al.   Science Translational Medicine

OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels

(2018) Swetha E Murthy et al.   eLife

Cryo-EM structure of the mechanically activated ion channel OSCA1.2

(2018) Sebastian Jojoa-Cruz et al.   eLife

Piezo’s membrane footprint and its contribution to mechanosensitivity

(2018) Christoph A Haselwandter et al.   eLife

Electron cryo-microscopy structure of the mechanotransduction channel NOMPC

(2017) Peng Jin et al.   NATURE

K2P2.1 (TREK-1)–activator complexes reveal a cryptic selectivity filter binding site

(2017) Marco Lolicato et al.   NATURE

Structure of the mechanically activated ion channel Piezo1

(2017) Kei Saotome et al.   NATURE

Piezos thrive under pressure: mechanically activated ion channels in health and disease

(2017) Swetha E. Murthy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Tension-sensitive Ion Transport Activity of MSL8 is Critical for its Function in Pollen Hydration and Germination

(2017) Eric S. Hamilton et al.   PLANT AND CELL PHYSIOLOGY

Asymmetric mechanosensitivity in a eukaryotic ion channel

(2017) Michael V. Clausen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piezo channels and GsMTx4: Two milestones in our understanding of excitatory mechanosensitive channels and their role in pathology

(2017) Thomas M. Suchyna   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel

(2017) Prafulla Aryal et al.   STRUCTURE

Inactivation of Mechanically Activated Piezo1 Ion Channels Is Determined by the C-Terminal Extracellular Domain and the Inner Pore Helix

(2017) Jason Wu et al.   Cell Reports

Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes

(2017) M Rocio Servin-Vences et al.   eLife

Structure-based membrane dome mechanism for Piezo mechanosensitivity

(2017) Yusong R Guo et al.   eLife

Dynamic regulation of TREK1 gating by Polycystin 2 via a Filamin A-mediated cytoskeletal Mechanism

(2017) Steven Li Fraine et al.   Scientific Reports

A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels

(2016) Marcus Schewe et al.   CELL

Toward a structural blueprint for bilayer-mediated channel mechanosensitivity

(2016) Navid Bavi et al.   Channels

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states

(2016) Conor McClenaghan et al.   JOURNAL OF GENERAL PHYSIOLOGY

The Combined Effect of Hydrophobic Mismatch and Bilayer Local Bending on the Regulation of Mechanosensitive Ion Channels

(2016) Omid Bavi et al.   PLoS One

The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels

(2016) Navid Bavi et al.   Nature Communications

Piezo1 Channels Are Inherently Mechanosensitive

(2016) Ruhma Syeda et al.   Cell Reports

How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2

(2015) Stephen G. Brohawn   Annals of the New York Academy of Sciences

United in Diversity: Mechanosensitive Ion Channels in Plants

(2015) Eric S. Hamilton et al.   Annual Review of Plant Biology

Architecture of the mammalian mechanosensitive Piezo1 channel

(2015) Jingpeng Ge et al.   NATURE

The role of lipids in mechanosensation

(2015) Christos Pliotas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanically Activated Ion Channels

(2015) Sanjeev S. Ranade et al.   NEURON

Mechanical coupling of the multiple structural elements of the large-conductance mechanosensitive channel during expansion

(2015) Jie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subunit composition of a DEG/ENaC mechanosensory channel ofCaenorhabditis elegans

(2015) Yushu Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

(2015) Y. Y. Dong et al.   SCIENCE

Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides

(2015) Istvan Borbiro et al.   Science Signaling

Piezo1 ion channel pore properties are dictated by C-terminal region

(2015) Bertrand Coste et al.   Nature Communications

The role of lipids in mechanosensation

(2015) Christos Pliotas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chemical activation of the mechanotransduction channel Piezo1

(2015) Ruhma Syeda et al.   eLife

Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides

(2015) Istvan Borbiro et al.   Science Signaling

DUF221 proteins are a family of osmosensitive calcium-permeable cation channels conserved across eukaryotes

(2014) Congcong Hou et al.   CELL RESEARCH

The cytoplasmic cage domain of the mechanosensitive channel MscS is a sensor of macromolecular crowding

(2014) Ian Rowe et al.   JOURNAL OF GENERAL PHYSIOLOGY

Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel

(2014) Stephen G. Brohawn et al.   NATURE

OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis

(2014) Fang Yuan et al.   NATURE

Transmembrane Helix Straightening and Buckling Underlies Activation of Mechanosensitive and Thermosensitive K2P Channels

(2014) Marco Lolicato et al.   NEURON

Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+channels

(2014) Stephen G. Brohawn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Feeling the hidden mechanical forces in lipid bilayer is an original sense

(2014) A. Anishkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch

(2014) Kate Poole et al.   Nature Communications

Single molecule FRET reveals pore size and opening mechanism of a mechano-sensitive ion channel

(2014) Yong Wang et al.   eLife

Stiffened lipid platforms at molecular force foci

(2013) A. Anishkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel

(2013) S. G. Brohawn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TMHS Is an Integral Component of the Mechanotransduction Machinery of Cochlear Hair Cells

(2012) Wei Xiong et al.   CELL

The dynamics of protein-protein interactions between domains of MscL at the cytoplasmic-lipid interface

(2012) Irene Iscla et al.   Channels

Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation

(2012) Zhiqiang Yan et al.   NATURE

Differential effects of lipids and lyso-lipids on the mechanosensitivity of the mechanosensitive channels MscL and MscS

(2012) T. Nomura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel

(2012) S. G. Brohawn et al.   SCIENCE

The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4

(2011) Chilman Bae et al.   BIOCHEMISTRY

Eukaryotic Mechanosensitive Channels

(2010) Jóhanna Árnadóttir et al.   Annual Review of Biophysics

Evidence for a protein tether involved in somatic touch

(2010) Jing Hu et al.   EMBO JOURNAL

The Role of the TRP Channel NompC in Drosophila Larval and Adult Locomotion

(2010) Li E. Cheng et al.   NEURON

Drosophila TRPN( = NOMPC) Channel Localizes to the Distal End of Mechanosensory Cilia

(2010) Jeongmi Lee et al.   PLoS One

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Amphipathic helices and membrane curvature

(2009) Guillaume Drin et al.   FEBS LETTERS

Mechanosensitive Channel MscS in the Open State: Modeling of the Transition, Explicit Simulations, and Experimental Measurements of Conductance

(2008) Andriy Anishkin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Neurosensory mechanotransduction

(2008) Martin Chalfie   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Structure of an Open Form of an E. coli Mechanosensitive Channel at 3.45 A Resolution

(2008) W. Wang et al.   SCIENCE

A Structural Mechanism for MscS Gating in Lipid Bilayers

(2008) V. Vasquez et al.   SCIENCE

Pore Mutations of the Escherichia coli MscS Channel Affect Desensitization but Not Ionic Preference

(2007) Michelle D. Edwards et al.   BIOPHYSICAL JOURNAL