Piezos thrive under pressure: mechanically activated ion channels in health and disease

Mechanical stretch triggers rapid epithelial cell division through Piezo1

(2017) S. A. Gudipaty et al.   NATURE

Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization

(2017) Adrienne E. Dubin et al.   NEURON

Stressed podocytes—mechanical forces, sensors, signaling and response

(2017) Karlhans Endlich et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Touch, Tension, and Transduction – The Function and Regulation of Piezo Ion Channels

(2017) Jason Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mechanical stress activates NMDA receptors in the absence of agonists

(2017) Mohammad Mehdi Maneshi et al.   Scientific Reports

Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels

(2017) Amanda H. Lewis et al.   Cell Reports

Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes

(2017) M Rocio Servin-Vences et al.   eLife

Piezo2: A Candidate Biomarker for Visceral Hypersensitivity in Irritable Bowel Syndrome?

(2017) Tao Bai et al.   Journal of Neurogastroenterology and Motility

Biallelic Loss of Proprioception-Related PIEZO2 Causes Muscular Atrophy with Perinatal Respiratory Distress, Arthrogryposis, and Scoliosis

(2016) Andrea Delle Vedove et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Loss of the proprioception and touch sensation channel PIEZO2 in siblings with a progressive form of contractures

(2016) A.A. Mahmud et al.   CLINICAL GENETICS

Exome sequencing identifies potential novel candidate genes in patients with unexplained colorectal adenomatous polyposis

(2016) Isabel Spier et al.   Familial Cancer

Regulation of Piezo2 Mechanotransduction by Static Plasma Membrane Tension in Primary Afferent Neurons

(2016) Zhanfeng Jia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin-mediated mechanotransduction

(2016) Zhiqi Sun et al.   JOURNAL OF CELL BIOLOGY

Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

(2016) ShengPeng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

The Hv1 proton channel responds to mechanical stimuli

(2016) Medha M. Pathak et al.   JOURNAL OF GENERAL PHYSIOLOGY

Recessive PIEZO2 stop mutation causes distal arthrogryposis with distal muscle weakness, scoliosis and proprioception defects

(2016) Goknur Haliloglu et al.   JOURNAL OF HUMAN GENETICS

Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces

(2016) Fan Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Native Piezo2 Interactomics Identifies Pericentrin as a Novel Regulator of Piezo2 in Somatosensory Neurons

(2016) Pratibha Narayanan et al.   JOURNAL OF PROTEOME RESEARCH

Piezo2 senses airway stretch and mediates lung inflation-induced apnoea

(2016) Keiko Nonomura et al.   NATURE

Mechanosensory hair cells express two molecularly distinct mechanotransduction channels

(2016) Zizhen Wu et al.   NATURE NEUROSCIENCE

Mechanosensing is critical for axon growth in the developing brain

(2016) David E Koser et al.   NATURE NEUROSCIENCE

Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels

(2016) Qiancheng Zhao et al.   NEURON

Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function

(2016) Gyu-Sang Hong et al.   NEURON

The Role of PIEZO2 in Human Mechanosensation

(2016) Alexander T. Chesler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Piezo1-dependent regulation of urinary osmolarity

(2016) Joana Raquel Martins et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

(2016) Charles D. Cox et al.   Nature Communications

Localized force application reveals mechanically sensitive domains of Piezo1

(2016) Jason Wu et al.   Nature Communications

Piezo1 Channels Are Inherently Mechanosensitive

(2016) Ruhma Syeda et al.   Cell Reports

A critical role for Piezo2 channels in the mechanotransduction of mouse proprioceptive neurons

(2016) Danny Florez-Paz et al.   Scientific Reports

A family of distal arthrogryposis type 5 due to a novelPIEZO2mutation

(2015) Mariko Okubo et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Feeling Force: Physical and Physiological Principles Enabling Sensory Mechanotransduction

(2015) Samata Katta et al.   Annual Review of Cell and Developmental Biology

Ankyrin Repeats Convey Force to Gate the NOMPC Mechanotransduction Channel

(2015) Wei Zhang et al.   CELL

Mammalian touch catches up

(2015) Carolyn M Walsh et al.   CURRENT OPINION IN NEUROBIOLOGY

The elusive mechanotransduction machinery of hair cells

(2015) Bo Zhao et al.   CURRENT OPINION IN NEUROBIOLOGY

Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia

(2015) B. E. Shmukler et al.   HAEMATOLOGICA

Protonation of the Human PIEZO1 Ion Channel Stabilizes Inactivation

(2015) Chilman Bae et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architecture of the mammalian mechanosensitive Piezo1 channel

(2015) Jingpeng Ge et al.   NATURE

Piezo2 is the principal mechanotransduction channel for proprioception

(2015) Seung-Hyun Woo et al.   NATURE NEUROSCIENCE

The role of lipids in mechanosensation

(2015) Christos Pliotas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanically Activated Ion Channels

(2015) Sanjeev S. Ranade et al.   NEURON

Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides

(2015) Istvan Borbiro et al.   Science Signaling

Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons

(2015) Yanmei Qi et al.   Nature Communications

Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia

(2015) Viktor Lukacs et al.   Nature Communications

Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis

(2015) Elisavet Fotiou et al.   Nature Communications

Piezo1 ion channel pore properties are dictated by C-terminal region

(2015) Bertrand Coste et al.   Nature Communications

The role of lipids in mechanosensation

(2015) Christos Pliotas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling

(2015) Kevin Retailleau et al.   Cell Reports

Chemical activation of the mechanotransduction channel Piezo1

(2015) Ruhma Syeda et al.   eLife

Piezo1 links mechanical forces to red blood cell volume

(2015) Stuart M Cahalan et al.   eLife

Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia

(2015) B. E. Shmukler et al.   HAEMATOLOGICA

Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides

(2015) Istvan Borbiro et al.   Science Signaling

Mechanosensitive Gating of Kv Channels

(2015) Catherine E. Morris et al.   PLoS One

Ionic Selectivity and Permeation Properties of Human PIEZO1 Channels

(2015) Radhakrishnan Gnanasambandam et al.   PLoS One

Mutations in PIEZO2 Cause Gordon Syndrome, Marden-Walker Syndrome, and Distal Arthrogryposis Type 5

(2014) Margaret J. McMillin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Merkel Cells Transduce and Encode Tactile Stimuli to Drive Aβ-Afferent Impulses

(2014) Ryo Ikeda et al.   CELL

Epithelial Homeostasis

(2014) Ian G. Macara et al.   CURRENT BIOLOGY

Functional Role for Piezo1 in Stretch-evoked Ca2+Influx and ATP Release in Urothelial Cell Cultures

(2014) Tatsuya Miyamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

(2014) Sanjeev S. Ranade et al.   NATURE

Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors

(2014) Srdjan Maksimovic et al.   NATURE

Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel

(2014) Stephen G. Brohawn et al.   NATURE

Piezo2 is required for Merkel-cell mechanotransduction

(2014) Seung-Hyun Woo et al.   NATURE

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

(2014) Medha M. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

(2014) Whasil Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl

(2014) E. R. Schneider et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of a Conserved Piezo Channel Domain Reveals a Topologically Distinct β Sandwich Fold

(2014) Aron Kamajaya et al.   STRUCTURE

Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch

(2014) Kate Poole et al.   Nature Communications

Human PIEZO1: Removing Inactivation

(2013) Chilman Bae et al.   BIOPHYSICAL JOURNAL

Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1

(2013) I. Andolfo et al.   BLOOD

Mechano-Gated Ion Channels in Sensory Systems

(2013) Patrick Delmas et al.   CELL

Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells

(2013) Rémi Peyronnet et al.   EMBO REPORTS

Piezo1 plays a role in erythrocyte volume homeostasis

(2013) A. Faucherre et al.   HAEMATOLOGICA

piezo2bRegulates Vertebrate Light Touch Response

(2013) Adèle Faucherre et al.   JOURNAL OF NEUROSCIENCE

Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets

(2013) Gary M. Mawe et al.   Nature Reviews Gastroenterology & Hepatology

Identification and Analysis of Putative Homologues of Mechanosensitive Channels in Pathogenic Protozoa

(2013) David L. Prole et al.   PLoS One

Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis

(2013) B. Coste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1

(2013) C. Bae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis

(2012) R. Zarychanski et al.   BLOOD

Gating the mechanical channel Piezo1

(2012) Philip A. Gottlieb et al.   Channels

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia

(2012) George T. Eisenhoffer et al.   NATURE

The role of Drosophila Piezo in mechanical nociception

(2012) Sung Eun Kim et al.   NATURE

Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel

(2012) S. G. Brohawn et al.   SCIENCE

Inflammatory Signals Enhance Piezo2-Mediated Mechanosensitive Currents

(2012) Adrienne E. Dubin et al.   Cell Reports

The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4

(2011) Chilman Bae et al.   BIOCHEMISTRY

More than a feeling: discovering, understanding, and influencing mechanosensing pathways

(2011) Andrew W Holle et al.   CURRENT OPINION IN BIOTECHNOLOGY

A Hitchhiker's Guide to Mechanobiology

(2011) Jeroen Eyckmans et al.   DEVELOPMENTAL CELL

Stomatin-domain proteins

(2011) Liudmilla Lapatsina et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Molecular mechanisms of mechanotransduction in mammalian sensory neurons

(2011) Patrick Delmas et al.   NATURE REVIEWS NEUROSCIENCE

Eukaryotic Mechanosensitive Channels

(2010) Jóhanna Árnadóttir et al.   Annual Review of Biophysics

Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel

(2010) Arthur Beyder et al.   JOURNAL OF PHYSIOLOGY-LONDON

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Neurosensory mechanotransduction

(2008) Martin Chalfie   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction in vascular physiology and atherogenesis

(2008) Cornelia Hahn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY