K2P2.1 (TREK-1)–activator complexes reveal a cryptic selectivity filter binding site

Development of the First Two-Pore Domain Potassium Channel TWIK-Related K+ Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity

(2017) Delphine Vivier et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels

(2016) Marcus Schewe et al.   CELL

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states

(2016) Conor McClenaghan et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs

(2016) Lin Tang et al.   NATURE

Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs

(2016) Maria V. Yelshanskaya et al.   NEURON

Novel cell-free high-throughput screening method for pharmacological tools targeting K+channels

(2016) Zhenwei Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial Voltage-Gated Sodium Channels (BacNaVs) from the Soil, Sea, and Salt Lakes Enlighten Molecular Mechanisms of Electrical Signaling and Pharmacology in the Brain and Heart

(2015) Jian Payandeh et al.   JOURNAL OF MOLECULAR BIOLOGY

The family of K2Pchannels: salient structural and functional properties

(2015) Sylvain Feliciangeli et al.   JOURNAL OF PHYSIOLOGY-LONDON

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

(2015) Y. Y. Dong et al.   SCIENCE

Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel

(2014) Stephen G. Brohawn et al.   NATURE

Transmembrane Helix Straightening and Buckling Underlies Activation of Mechanosensitive and Thermosensitive K2P Channels

(2014) Marco Lolicato et al.   NEURON

Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism

(2014) C. Bagneris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cation-π interactions of methylated ammonium ions: A quantum mechanical study

(2014) Chaya Rapp et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels

(2013) Sviatoslav N. Bagriantsev et al.   ACS Chemical Biology

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Better models by discarding data?

(2013) K. Diederichs et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel

(2013) S. G. Brohawn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of TREK-1 by morphine results in analgesia without adverse side effects

(2013) Maïly Devilliers et al.   Nature Communications

Metabolic and thermal stimuli control K2P2.1 (TREK-1) through modular sensory and gating domains

(2012) Sviatoslav N Bagriantsev et al.   EMBO JOURNAL

Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel

(2012) S. G. Brohawn et al.   SCIENCE

Crystal Structure of the Human Two-Pore Domain Potassium Channel K2P1

(2012) A. N. Miller et al.   SCIENCE

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

The pore structure and gating mechanism of K2P channels

(2011) Paula L Piechotta et al.   EMBO JOURNAL

Multiple modalities converge on a common gate to control K2Pchannel function

(2011) Sviatoslav N Bagriantsev et al.   EMBO JOURNAL

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins

(2011) D. Shaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Modulation of protein properties in living cells using nanobodies

(2009) Axel Kirchhofer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue

(2009) G. Sandoz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Mechanism for Human K2P2.1 Channel Gating

(2008) Asi Cohen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GFP-based optimization scheme for the overexpression and purification of eukaryotic membrane proteins in Saccharomyces cerevisiae

(2008) David Drew et al.   Nature Protocols