Electron cryo-microscopy structure of the mechanotransduction channel NOMPC

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Assembly and activation of dynein–dynactin by the cargo adaptor protein Hook3

(2016) Courtney M. Schroeder et al.   JOURNAL OF CELL BIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution

(2016) Jianping Wu et al.   NATURE

Crystal structure of the epithelial calcium channel TRPV6

(2016) Kei Saotome et al.   NATURE

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

(2016) Charles D. Cox et al.   Nature Communications

Structure of the full-length TRPV2 channel by cryo-EM

(2016) Kevin W. Huynh et al.   Nature Communications

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ankyrin Repeats Convey Force to Gate the NOMPC Mechanotransduction Channel

(2015) Wei Zhang et al.   CELL

Structure of the TRPA1 ion channel suggests regulatory mechanisms

(2015) Candice E. Paulsen et al.   NATURE

EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy

(2015) Benjamin A Barad et al.   NATURE METHODS

L596–W733 bond between the start of the S4–S5 linker and the TRP box stabilizes the closed state of TRPV4 channel

(2015) Jinfeng Teng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist

(2015) S. Ahuja et al.   SCIENCE

Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel

(2014) Stephen G. Brohawn et al.   NATURE

A robust pipeline for rapid production of versatile nanobody repertoires

(2014) Peter C Fridy et al.   NATURE METHODS

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

(2014) April Goehring et al.   Nature Protocols

Transmembrane Helix Straightening and Buckling Underlies Activation of Mechanosensitive and Thermosensitive K2P Channels

(2014) Marco Lolicato et al.   NEURON

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

A NOMPC-Dependent Membrane-Microtubule Connector Is a Candidate for the Gating Spring in Fly Mechanoreceptors

(2013) Xin Liang et al.   CURRENT BIOLOGY

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Stiffened lipid platforms at molecular force foci

(2013) A. Anishkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PRIME: Probabilistic Initial 3D Model Generation for Single-Particle Cryo-Electron Microscopy

(2013) Hans Elmlund et al.   STRUCTURE

Exome Sequencing Reveals Mutations in TRPV3 as a Cause of Olmsted Syndrome

(2012) Zhimiao Lin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation

(2012) Zhiqiang Yan et al.   NATURE

Prevention of overfitting in cryo-EM structure determination

(2012) Sjors H W Scheres et al.   NATURE METHODS

Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel

(2012) S. G. Brohawn et al.   SCIENCE

CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures

(2012) Eva Chovancova et al.   PLoS Computational Biology

NompC TRP Channel Is Essential for Drosophila Sound Receptor Function

(2011) Thomas Effertz et al.   CURRENT BIOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Eukaryotic Mechanosensitive Channels

(2010) Jóhanna Árnadóttir et al.   Annual Review of Biophysics

The Role of the TRP Channel NompC in Drosophila Larval and Adult Locomotion

(2010) Li E. Cheng et al.   NEURON

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY