The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels

Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels

(2016) Qiancheng Zhao et al.   NEURON

Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

(2016) Charles D. Cox et al.   Nature Communications

Ankyrin Repeats Convey Force to Gate the NOMPC Mechanotransduction Channel

(2015) Wei Zhang et al.   CELL

The Effect of Detergent, Temperature, and Lipid on the Oligomeric State of MscL Constructs: Insights from Mass Spectrometry

(2015) Eamonn Reading et al.   CHEMISTRY & BIOLOGY

Unidirectional incorporation of a bacterial mechanosensitive channel into liposomal membranes

(2015) Takeshi Nomura et al.   FASEB JOURNAL

Architecture of the mammalian mechanosensitive Piezo1 channel

(2015) Jingpeng Ge et al.   NATURE

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

The role of lipids in mechanosensation

(2015) Christos Pliotas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanically Activated Ion Channels

(2015) Sanjeev S. Ranade et al.   NEURON

Mutations in a Conserved Domain of E. coli MscS to the Most Conserved Superfamily Residue Leads to Kinetic Changes

(2015) Hannah R. Malcolm et al.   PLoS One

L596–W733 bond between the start of the S4–S5 linker and the TRP box stabilizes the closed state of TRPV4 channel

(2015) Jinfeng Teng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical coupling of the multiple structural elements of the large-conductance mechanosensitive channel during expansion

(2015) Jie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

(2015) Y. Y. Dong et al.   SCIENCE

The role of lipids in mechanosensation

(2015) Christos Pliotas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Scanning MscL Channels with Targeted Post-Translational Modifications for Functional Alterations

(2015) Irene Iscla et al.   PLoS One

Membrane proteins bind lipids selectively to modulate their structure and function

(2014) Arthur Laganowsky et al.   NATURE

Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel

(2014) Stephen G. Brohawn et al.   NATURE

Transmembrane Helix Straightening and Buckling Underlies Activation of Mechanosensitive and Thermosensitive K2P Channels

(2014) Marco Lolicato et al.   NEURON

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

The force-from-lipid (FFL) principle of mechanosensitivity, at large and in elements

(2014) Jinfeng Teng et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Force Transduction and Lipid Binding in MscL: A Continuum-Molecular Approach

(2014) Juan M. Vanegas et al.   PLoS One

Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+channels

(2014) Stephen G. Brohawn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biophysical implications of lipid bilayer rheometry for mechanosensitive channels

(2014) N. Bavi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and stability of the C-terminal helical bundle of theE. colimechanosensitive channel of large conductance

(2013) Troy A. Walton et al.   PROTEIN SCIENCE

Bacterial Mechanosensitive Channels—MscS: Evolution's Solution to Creating Sensitivity in Function

(2012) James H. Naismith et al.   Annual Review of Biophysics

Sensing and Responding to Membrane Tension: The Bacterial MscL Channel as a Model System

(2012) Irene Iscla et al.   BIOPHYSICAL JOURNAL

Molecular force transduction by ion channels – diversity and unifying principles

(2012) Sergei Sukharev et al.   JOURNAL OF CELL SCIENCE

Differential effects of lipids and lyso-lipids on the mechanosensitivity of the mechanosensitive channels MscL and MscS

(2012) T. Nomura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel

(2012) S. G. Brohawn et al.   SCIENCE

Mechanosensitive Channels: What Can They Do and How Do They Do It?

(2011) Elizabeth S. Haswell et al.   STRUCTURE

An improved open-channel structure of MscL determined from FRET confocal microscopy and simulation

(2010) Ben Corry et al.   JOURNAL OF GENERAL PHYSIOLOGY

The Membrane-Bound State of K2PPotassium Channels

(2010) Werner Treptow et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biophysics and Structure of the Patch and the Gigaseal

(2009) Thomas M. Suchyna et al.   BIOPHYSICAL JOURNAL

Emerging roles for lipids in shaping membrane-protein function

(2009) Rob Phillips et al.   NATURE

On the Structure of the N-Terminal Domain of the MscL Channel: Helical Bundle or Membrane Interface

(2008) Irene Iscla et al.   BIOPHYSICAL JOURNAL

Gating Mechanisms of Mechanosensitive Channels of Large Conductance, I: A Continuum Mechanics-Based Hierarchical Framework

(2008) Xi Chen et al.   BIOPHYSICAL JOURNAL

Mechanosensitive Channels: Insights from Continuum-Based Simulations

(2008) Yuye Tang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

A Structural Mechanism for MscS Gating in Lipid Bilayers

(2008) V. Vasquez et al.   SCIENCE