Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1

Structure and mechanogating mechanism of the Piezo1 channel

(2018) Qiancheng Zhao et al.   NATURE

A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel

(2018) Yanfeng Wang et al.   Nature Communications

Mechanical stretch triggers rapid epithelial cell division through Piezo1

(2017) S. A. Gudipaty et al.   NATURE

Structure of the mechanically activated ion channel Piezo1

(2017) Kei Saotome et al.   NATURE

Functional and Molecular Characterization of Mechanoinsensitive “Silent” Nociceptors

(2017) Vincenzo Prato et al.   Cell Reports

Piezo2: A Candidate Biomarker for Visceral Hypersensitivity in Irritable Bowel Syndrome?

(2017) Tao Bai et al.   Journal of Neurogastroenterology and Motility

Biallelic Loss of Proprioception-Related PIEZO2 Causes Muscular Atrophy with Perinatal Respiratory Distress, Arthrogryposis, and Scoliosis

(2016) Andrea Delle Vedove et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Familial Gordon syndrome associated with aPIEZO2mutation

(2016) Franz Alisch et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Loss of the proprioception and touch sensation channel PIEZO2 in siblings with a progressive form of contractures

(2016) A.A. Mahmud et al.   CLINICAL GENETICS

Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

(2016) ShengPeng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Recessive PIEZO2 stop mutation causes distal arthrogryposis with distal muscle weakness, scoliosis and proprioception defects

(2016) Goknur Haliloglu et al.   JOURNAL OF HUMAN GENETICS

Piezo2 senses airway stretch and mediates lung inflation-induced apnoea

(2016) Keiko Nonomura et al.   NATURE

Mechanosensory hair cells express two molecularly distinct mechanotransduction channels

(2016) Zizhen Wu et al.   NATURE NEUROSCIENCE

Intersubunit Concerted Cooperative and cis-Type Mechanisms Modulate Allosteric Gating in Two-Pore-Domain Potassium Channel TREK-2

(2016) Ren-Gong Zhuo et al.   Frontiers in Cellular Neuroscience

Piezo1 Channels Are Inherently Mechanosensitive

(2016) Ruhma Syeda et al.   Cell Reports

Novel Gardos channel mutations linked to dehydrated hereditary stomatocytosis (xerocytosis)

(2015) Immacolata Andolfo et al.   AMERICAN JOURNAL OF HEMATOLOGY

A family of distal arthrogryposis type 5 due to a novelPIEZO2mutation

(2015) Mariko Okubo et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

A combined coarse-grained and all-atom simulation of TRPV1 channel gating and heat activation

(2015) Wenjun Zheng et al.   JOURNAL OF GENERAL PHYSIOLOGY

Contribution of Piezo2 to Endothelium-Dependent Pain

(2015) Luiz F. Ferrari et al.   Molecular Pain

Architecture of the mammalian mechanosensitive Piezo1 channel

(2015) Jingpeng Ge et al.   NATURE

Piezo2 is the principal mechanotransduction channel for proprioception

(2015) Seung-Hyun Woo et al.   NATURE NEUROSCIENCE

Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis

(2015) Elisavet Fotiou et al.   Nature Communications

Piezo1 ion channel pore properties are dictated by C-terminal region

(2015) Bertrand Coste et al.   Nature Communications

Chemical activation of the mechanotransduction channel Piezo1

(2015) Ruhma Syeda et al.   eLife

Piezo1 links mechanical forces to red blood cell volume

(2015) Stuart M Cahalan et al.   eLife

Mutations in PIEZO2 Cause Gordon Syndrome, Marden-Walker Syndrome, and Distal Arthrogryposis Type 5

(2014) Margaret J. McMillin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

(2014) Sanjeev S. Ranade et al.   NATURE

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

(2014) Medha M. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Slower Piezo1 Inactivation in Dehydrated Hereditary Stomatocytosis (Xerocytosis)

(2013) Sophie Demolombe et al.   BIOPHYSICAL JOURNAL

Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1

(2013) I. Andolfo et al.   BLOOD

Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis

(2013) B. Coste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KCNQ1 Channels Do Not Undergo Concerted but Sequential Gating Transitions in Both the Absence and the Presence of KCNE1 Protein

(2012) Eshcar Meisel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia

(2012) George T. Eisenhoffer et al.   NATURE

Inflammatory Signals Enhance Piezo2-Mediated Mechanosensitive Currents

(2012) Adrienne E. Dubin et al.   Cell Reports

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

The opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativity

(2009) Francesco Tombola et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Structural Mechanism for MscS Gating in Lipid Bilayers

(2008) V. Vasquez et al.   SCIENCE