Mechanically activated piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis

Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection

(2018) Shang Ma et al.   CELL

The mechanobiology of zebrafish cardiac valve leaflet formation

(2018) Alessio Paolini et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel

(2018) Li He et al.   NATURE

Continuous addition of progenitors forms the cardiac ventricle in zebrafish

(2018) Anastasia Felker et al.   Nature Communications

Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration

(2018) Héctor Sánchez-Iranzo et al.   Nature Communications

Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis

(2018) Stefan Donat et al.   eLife

A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice

(2018) Lorriane Eley et al.   eLife

Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation

(2018) Keiko Nonomura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Laminar flow downregulates Notch activity to promote lymphatic sprouting

(2017) Dongwon Choi et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial Notch signalling limits angiogenesis via control of artery formation

(2017) Sana S. Hasan et al.   NATURE CELL BIOLOGY

Dll4 and Notch signalling couples sprouting angiogenesis and artery formation

(2017) Mara E. Pitulescu et al.   NATURE CELL BIOLOGY

Piezos thrive under pressure: mechanically activated ion channels in health and disease

(2017) Swetha E. Murthy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NOTCH1 is a mechanosensor in adult arteries

(2017) Julia J. Mack et al.   Nature Communications

Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels

(2017) Amanda H. Lewis et al.   Cell Reports

Hemodynamics driven cardiac valve morphogenesis

(2016) Emily Steed et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and MorphogenesisNovelty and Significance

(2016) Donal MacGrogan et al.   CIRCULATION RESEARCH

Real-time 3D visualization of cellular rearrangements during cardiac valve formation

(2016) Jenny Pestel et al.   DEVELOPMENT

Endothelial fluid shear stress sensing in vascular health and disease

(2016) Nicolas Baeyens et al.   JOURNAL OF CLINICAL INVESTIGATION

Evolution of the fish heart by sub/neofunctionalization of an elastin gene

(2016) Yuuta Moriyama et al.   Nature Communications

klf2a couples mechanotransduction and zebrafish valve morphogenesis through fibronectin synthesis

(2016) Emily Steed et al.   Nature Communications

Endocardial Notch Signaling in Cardiac Development and Disease

(2015) Guillermo Luxán et al.   CIRCULATION RESEARCH

Oscillatory Flow Modulates Mechanosensitive klf2a Expression through trpv4 and trpp2 during Heart Valve Development

(2015) Emilie Heckel et al.   CURRENT BIOLOGY

Cardiac contraction activates endocardial Notch signaling to modulate chamber maturation in zebrafish

(2015) L. A. Samsa et al.   DEVELOPMENT

Notch-Tnf signalling is required for development and homeostasis of arterial valves

(2015) Yidong Wang et al.   EUROPEAN HEART JOURNAL

Mutations in DCHS1 cause mitral valve prolapse

(2015) Ronen Durst et al.   NATURE

Lymphatic vessels arise from specialized angioblasts within a venous niche

(2015) J. Nicenboim et al.   NATURE

Genetic association analyses highlight biological pathways underlying mitral valve prolapse

(2015) Christian Dina et al.   NATURE GENETICS

Mechanically Activated Ion Channels

(2015) Sanjeev S. Ranade et al.   NEURON

Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons

(2015) Yanmei Qi et al.   Nature Communications

Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia

(2015) Viktor Lukacs et al.   Nature Communications

Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling

(2015) Kevin Retailleau et al.   Cell Reports

Amotl2a interacts with the Hippo effector Yap1 and the Wnt/β-catenin effector Lef1 to control tissue size in zebrafish

(2015) Sobhika Agarwala et al.   eLife

Establishment of transgenic lines to monitor and manipulate Yap/Taz-Tead activity in zebrafish reveals both evolutionarily conserved and divergent functions of the Hippo pathway

(2014) Joel B. Miesfeld et al.   MECHANISMS OF DEVELOPMENT

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

(2014) Medha M. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

(2014) Whasil Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch

(2014) Kate Poole et al.   Nature Communications

GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development

(2014) Sonia Stefanovic et al.   Nature Communications

Biomechanical factors in the biology of aortic wall and aortic valve diseases

(2013) Magnus Bäck et al.   CARDIOVASCULAR RESEARCH

Heartbeat-Driven Pericardiac Fluid Forces Contribute to Epicardium Morphogenesis

(2013) Marina Peralta et al.   CURRENT BIOLOGY

Pulse propagation by a capacitive mechanism drives embryonic blood flow

(2013) H. Anton et al.   DEVELOPMENT

Filopodia are dispensable for endothelial tip cell guidance

(2013) Li-Kun Phng et al.   DEVELOPMENT

Human haemodynamic frequency harmonics regulate the inflammatory phenotype of vascular endothelial cells

(2013) Ryan E. Feaver et al.   Nature Communications

Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis

(2012) R. Zarychanski et al.   BLOOD

Developmental basis for filamin-A-associated myxomatous mitral valve disease

(2012) Kimberly Sauls et al.   CARDIOVASCULAR RESEARCH

Different levels of Notch signaling regulate quiescence, renewal and differentiation in pancreatic endocrine progenitors

(2012) N. Ninov et al.   DEVELOPMENT

Partitioning the heart: mechanisms of cardiac septation and valve development

(2012) C.-J. Lin et al.   DEVELOPMENT

Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia

(2012) George T. Eisenhoffer et al.   NATURE

Identification and Functional Characterization of Cardiac Pacemaker Cells in Zebrafish

(2012) Federico Tessadori et al.   PLoS One

Loss of Gata5 in mice leads to bicuspid aortic valve

(2011) Brigitte Laforest et al.   JOURNAL OF CLINICAL INVESTIGATION

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling

(2011) Tuomas Tammela et al.   NATURE CELL BIOLOGY

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Polycystin-1 and -2 Dosage Regulates Pressure Sensing

(2009) Reza Sharif-Naeini et al.   CELL

Recurrence of Congenital Heart Defects in Families

(2009) Nina Øyen et al.   CIRCULATION

TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling

(2009) Charles K. Thodeti et al.   CIRCULATION RESEARCH

Heart Valve Development

(2009) Michelle D. Combs et al.   CIRCULATION RESEARCH

Reversing Blood Flows Act through klf2a to Ensure Normal Valvulogenesis in the Developing Heart

(2009) Julien Vermot et al.   PLOS BIOLOGY

High-speed imaging of developing heart valves reveals interplay of morphogenesis and function

(2008) P. J. Scherz et al.   DEVELOPMENT

TRPP2 and TRPV4 form a polymodal sensory channel complex

(2008) Michael Köttgen et al.   JOURNAL OF CELL BIOLOGY

High-resolution in situ hybridization to whole-mount zebrafish embryos

(2007) Christine Thisse et al.   Nature Protocols