Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Functional relevance of NLRP3 inflammasome-mediated interleukin (IL)-1β during acute allergic airway inflammation

(2014) M. Ritter et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Sulforaphane and prostate cancer interception

(2014) Maria H. Traka et al.   DRUG DISCOVERY TODAY

P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1  in Mouse Macrophage

(2014) P. Pelegrin et al.   JOURNAL OF IMMUNOLOGY

Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function

(2014) Baptiste Guey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anthrax lethal and edema toxins in anthrax pathogenesis

(2014) Shihui Liu et al.   TRENDS IN MICROBIOLOGY

Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii

(2014) G. Gorfu et al.   mBio

Inflammasomes

(2014) M. R. de Zoete et al.   Cold Spring Harbor Perspectives in Biology

Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

(2014) Nina Van Opdenbosch et al.   Nature Communications

Inflammasome Sensor NLRP1 Controls Rat Macrophage Susceptibility to Toxoplasma gondii

(2014) Kimberly M. Cirelli et al.   PLoS Pathogens

NLRP1 Is an Inflammasome Sensor for Toxoplasma gondii

(2013) Sarah E. Ewald et al.   INFECTION AND IMMUNITY

Arsenic Trioxide and Other Arsenical Compounds Inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 Inflammasomes

(2013) N. K. Maier et al.   JOURNAL OF IMMUNOLOGY

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Sulforaphane: translational research from laboratory bench to clinic

(2013) Christine A Houghton et al.   NUTRITION REVIEWS

Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles

(2013) David Heber et al.   Food & Function

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial

(2012) Zahra Bahadoran et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Caspase-1 Has Both Proinflammatory and Regulatory Properties in Helicobacter Infections, Which Are Differentially Mediated by Its Substrates IL-1  and IL-18

(2012) I. Hitzler et al.   JOURNAL OF IMMUNOLOGY

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

(2012) Jakob von Moltke et al.   NATURE

Anthrax Lethal Factor Cleaves Mouse Nlrp1b in Both Toxin-Sensitive and Toxin-Resistant Macrophages

(2012) Kristina A. Hellmich et al.   PLoS One

Glucosinolates and isothiocyanates in health and disease

(2012) Albena T. Dinkova-Kostova et al.   TRENDS IN MOLECULAR MEDICINE

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome

(2012) Jonathan L. Levinsohn et al.   PLoS Pathogens

Deregulated inflammasome signaling in disease

(2011) Mohamed Lamkanfi et al.   IMMUNOLOGICAL REVIEWS

NLRP3/Caspase-1-Independent IL-1  Production Mediates Diesel Exhaust Particle-Induced Pulmonary Inflammation

(2011) S. Provoost et al.   JOURNAL OF IMMUNOLOGY

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

A cautionary note on using N-acetylcysteine as an antagonist to assess isothiocyanate-induced reactive oxygen species-mediated apoptosis

(2010) Lixin Mi et al.   ANALYTICAL BIOCHEMISTRY

Auranofin Protects against Anthrax Lethal Toxin-Induced Activation of the Nlrp1b Inflammasome

(2010) Zachary L. Newman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Why not treat human cancer with interleukin-1 blockade?

(2010) Charles A. Dinarello   CANCER AND METASTASIS REVIEWS

Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing

(2010) Petr Broz et al.   Cell Host & Microbe

Sulforaphane Activates Heat Shock Response and Enhances Proteasome Activity through Up-regulation of Hsp27

(2010) Nanqin Gan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Inflammasome Sensor Nlrp1b-Dependent Resistance to Anthrax Is Mediated by Caspase-1, IL-1 Signaling and Neutrophil Recruitment

(2010) Mahtab Moayeri et al.   PLoS Pathogens

Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout

(2009) William John Martin et al.   ARTHRITIS AND RHEUMATISM

Dietary Sulforaphane-Rich Broccoli Sprouts Reduce Colonization and Attenuate Gastritis in Helicobacter pylori-Infected Mice and Humans

(2009) A. Yanaka et al.   Cancer Prevention Research

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Sulforaphane Suppresses Oligomerization of TLR4 in a Thiol-Dependent Manner

(2009) Hyung Sun Youn et al.   JOURNAL OF IMMUNOLOGY

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

Multi-targeted prevention of cancer by sulforaphane

(2008) John D. Clarke et al.   CANCER LETTERS

Killing of macrophages by anthrax lethal toxin: involvement of the N-end rule pathway

(2008) Katherine E. Wickliffe et al.   CELLULAR MICROBIOLOGY

Heat shock inhibits caspase-1 activity while also preventing its inflammasome-mediated activation by anthrax lethal toxin

(2008) Tera C. Levin et al.   CELLULAR MICROBIOLOGY

Sulforaphane Enhances the Therapeutic Potential of TRAIL in Prostate Cancer Orthotopic Model through Regulation of Apoptosis, Metastasis, and Angiogenesis

(2008) S. Shankar et al.   CLINICAL CANCER RESEARCH

Covalent Binding to Tubulin by Isothiocyanates

(2008) Lixin Mi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

(2008) S. L. Fink et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA