Respiratory protease/antiprotease balance determines susceptibility to viral infection and can be modified by nutritional antioxidants

A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation

(2015) Meike Dittmann et al.   CELL

Surfactant Protein A Enhances Production of Secretory Leukoprotease Inhibitor and Protects It from Cleavage by Matrix Metalloproteinases

(2014) R. A. Ramadas et al.   JOURNAL OF IMMUNOLOGY

TMPRSS2 Is a Host Factor That Is Essential for Pneumotropism and Pathogenicity of H7N9 Influenza A Virus in Mice

(2014) C. Tarnow et al.   JOURNAL OF VIROLOGY

DESC1 and MSPL Activate Influenza A Viruses and Emerging Coronaviruses for Host Cell Entry

(2014) P. Zmora et al.   JOURNAL OF VIROLOGY

The Host Protease TMPRSS2 Plays a Major Role in In Vivo Replication of Emerging H7N9 and Seasonal Influenza Viruses

(2014) K. Sakai et al.   JOURNAL OF VIROLOGY

Nrf1 and Nrf2 Transcription Factors Regulate Androgen Receptor Transactivation in Prostate Cancer Cells

(2014) Michelle A. Schultz et al.   PLoS One

Effect of Broccoli Sprouts on Nasal Response to Live Attenuated Influenza Virus in Smokers: A Randomized, Double-Blind Study

(2014) Terry L. Noah et al.   PLoS One

Terminal sialic acid linkages determine different cell infectivities of human parainfluenza virus type 1 and type 3

(2014) Keijo Fukushima et al.   VIROLOGY

Regulation and activity of secretory leukoprotease inhibitor (SLPI) is altered in smokers

(2013) Megan Meyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Serpins, Immunity and Autoimmunity: Old Molecules, New Functions

(2013) Mariele Gatto et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

The role of the antileukoprotease SLPI in smoking-induced human papillomavirus-independent head and neck squamous cell carcinomas

(2013) Elgar Susanne Quabius et al.   INTERNATIONAL JOURNAL OF CANCER

Middle East Respiratory Syndrome Coronavirus Infection Mediated by the Transmembrane Serine Protease TMPRSS2

(2013) Kazuya Shirato et al.   JOURNAL OF VIROLOGY

Matriptase Proteolytically Activates Influenza Virus and Promotes Multicycle Replication in the Human Airway Epithelium

(2013) A. Beaulieu et al.   JOURNAL OF VIROLOGY

TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

(2013) A. Heurich et al.   JOURNAL OF VIROLOGY

TMPRSS2 Is an Activating Protease for Respiratory Parainfluenza Viruses

(2013) M. Abe et al.   JOURNAL OF VIROLOGY

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Human papillomavirus infection in head and neck cancer: The role of the secretory leukocyte protease inhibitor

(2013) MARKUS HOFFMANN et al.   ONCOLOGY REPORTS

Influenza A virus induction of oxidative stress and MMP-9 is associated with severe lung pathology in a mouse model

(2013) Yu-Hsiang Lee et al.   VIRUS RESEARCH

Tmprss2 Is Essential for Influenza H1N1 Virus Pathogenesis in Mice

(2013) Bastian Hatesuer et al.   PLoS Pathogens

Influenza HA Subtypes Demonstrate Divergent Phenotypes for Cleavage Activation and pH of Fusion: Implications for Host Range and Adaptation

(2013) Summer E. Galloway et al.   PLoS Pathogens

Amelioration of influenza virus-induced reactive oxygen species formation by epigallocatechin gallate derived from green tea

(2012) Jia-xin Ling et al.   ACTA PHARMACOLOGICA SINICA

Secretory Leukocyte Protease Inhibitor Binds to Neisseria gonorrhoeae Outer Membrane Opacity Protein and is Bactericidal

(2012) Morris D. Cooper et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Rhinovirus Infection Induces Degradation of Antimicrobial Peptides and Secondary Bacterial Infection in Chronic Obstructive Pulmonary Disease

(2012) Patrick Mallia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

(2012) Daniele Del Rio et al.   ANTIOXIDANTS & REDOX SIGNALING

SLPI and elafin: multifunctional antiproteases of the WFDC family

(2012) Aaron Scott et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cleavage Activation of the Human-Adapted Influenza Virus Subtypes by Matriptase Reveals both Subtype and Strain Specificities

(2012) B. S. Hamilton et al.   JOURNAL OF VIROLOGY

Matriptase, HAT, and TMPRSS2 Activate the Hemagglutinin of H9N2 Influenza A Viruses

(2012) Joanna Baron et al.   JOURNAL OF VIROLOGY

Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents

(2012) Sadagopan Magesh et al.   MEDICINAL RESEARCH REVIEWS

Exposure to Ozone Modulates Human Airway Protease/Antiprotease Balance Contributing to Increased Influenza A Infection

(2012) Matthew J. Kesic et al.   PLoS One

Influenza and SARS-Coronavirus Activating Proteases TMPRSS2 and HAT Are Expressed at Multiple Sites in Human Respiratory and Gastrointestinal Tracts

(2012) Stephanie Bertram et al.   PLoS One

In Vivo Anti-HIV Activity of the Heparin-Activated Serine Protease Inhibitor Antithrombin III Encapsulated in Lymph-Targeting Immunoliposomes

(2012) Mohammed Asmal et al.   PLoS One

Sulforaphane induces SLPI secretion in the nasal mucosa

(2012) Megan Meyer et al.   RESPIRATORY MEDICINE

Nectin 4 is the epithelial cell receptor for measles virus

(2012) Ryan S. Noyce et al.   TRENDS IN MICROBIOLOGY

A Review of α1-Antitrypsin Deficiency

(2011) James K. Stoller et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mecanismos moleculares de inflamación durante las agudizaciones de la enfermedad pulmonar obstructiva crónica

(2011) Ana L. Kersul et al.   ARCHIVOS DE BRONCONEUMOLOGIA

Matrix metalloproteinases in acute lung injury: mediators of injury and drivers of repair

(2011) A. Davey et al.   EUROPEAN RESPIRATORY JOURNAL

Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells

(2011) Matthew J. Kesic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sulforaphane inhibitsde novosynthesis of IL-8 and MCP-1 in human epithelial cells generated by cigarette smoke extract

(2011) Warren Starrett et al.   Journal of Immunotoxicology

Sulforaphane Induces Antioxidative and Antiproliferative Responses by Generating Reactive Oxygen Species in Human Bronchial Epithelial BEAS-2B Cells

(2011) Yoon-Jin Lee et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease

(2011) S. Bertram et al.   JOURNAL OF VIROLOGY

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

(2011) I. Glowacka et al.   JOURNAL OF VIROLOGY

Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model

(2011) C. J. Harvey et al.   Science Translational Medicine

Tumor Cell Marker PVRL4 (Nectin 4) Is an Epithelial Cell Receptor for Measles Virus

(2011) Ryan S. Noyce et al.   PLoS Pathogens

TMPRSS2, a Serine Protease Expressed in the Prostate on the Apical Surface of Luminal Epithelial Cells and Released into Semen in Prostasomes, Is Misregulated in Prostate Cancer Cells

(2010) Ya-Wen Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Secretory Leukocyte Protease Inhibitor and Elafin/Trappin-2

(2010) Jean-Michel Sallenave   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment

(2010) Toni M. Antalis et al.   BIOCHEMICAL JOURNAL

The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity

(2010) Keith Brew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Respiratory epithelial cells in innate immunity to influenza virus infection

(2010) Catherine J. Sanders et al.   CELL AND TISSUE RESEARCH

Candidate Dietary Phytochemicals Modulate Expression of Phase II Enzymes GSTP1 and NQO1 in Human Lung Cells

(2010) Xiang-Lin Tan et al.   JOURNAL OF NUTRITION

TMPRSS2 and TMPRSS4 Facilitate Trypsin-Independent Spread of Influenza Virus in Caco-2 Cells

(2010) S. Bertram et al.   JOURNAL OF VIROLOGY

Cleavage of Influenza Virus Hemagglutinin by Airway Proteases TMPRSS2 and HAT Differs in Subcellular Localization and Susceptibility to Protease Inhibitors

(2010) E. Bottcher-Friebertshauser et al.   JOURNAL OF VIROLOGY

Influenza Vaccines for the Future

(2010) Linda C. Lambert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel insights into proteolytic cleavage of influenza virus hemagglutinin

(2010) Stephanie Bertram et al.   REVIEWS IN MEDICAL VIROLOGY

Human Rhinovirus Infection Up-Regulates MMP-9 Production in Airway Epithelial Cells via NF-κB

(2009) Claire E. Tacon et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Moraxella catarrhalisacquisition, airway inflammation and protease-antiprotease balance in chronic obstructive pulmonary disease

(2009) Ganapathi I Parameswaran et al.   BMC INFECTIOUS DISEASES

Proteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery

(2009) Catherine M Greene et al.   BRITISH JOURNAL OF PHARMACOLOGY

Trappin-2/Elafin: a novel innate anti-human immunodeficiency virus-1 molecule of the human female reproductive tract

(2009) Mimi Ghosh et al.   IMMUNOLOGY

Preclinical development of the green tea catechin, epigallocatechin gallate, as an HIV-1 therapy

(2009) Christina L. Nance et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Type II Transmembrane Serine Proteases

(2009) Thomas H. Bugge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased Levels of Secretory Leucoprotease Inhibitor in the Pseudomonas-Infected Cystic Fibrosis Lung Are Due to Neutrophil Elastase Degradation

(2009) S. Weldon et al.   JOURNAL OF IMMUNOLOGY

Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic

(2009) Gavin J. D. Smith et al.   NATURE

Integrin  v 1 promotes infection by human metapneumovirus

(2009) G. Cseke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6

(2009) A. Gibbs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 protects against airway disorders

(2009) Hye-Youn Cho et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition

(2009) Eva Böttcher et al.   VACCINE

Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients

(2009) Say Li Kong et al.   VIRUS RESEARCH

Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1

(2008) Deepti Malhotra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Antiviral Activity of Nrf2 in a Murine Model of Respiratory Syncytial Virus Disease

(2008) Hye-Youn Cho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cleaved SLPI, a novel biomarker of chymase activity

(2008) Stanley M. Belkowski et al.   BIOLOGICAL CHEMISTRY

Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway

(2008) Marc A. Riedl et al.   CLINICAL IMMUNOLOGY

Delivery of rSLPI in a liposomal carrier for inhalation provides protection against cathepsin L degradation

(2008) Aileen M. Gibbons et al.   JOURNAL OF MICROENCAPSULATION

Efficient Multiplication of Human Metapneumovirus in Vero Cells Expressing the Transmembrane Serine Protease TMPRSS2

(2008) Y. Shirogane et al.   JOURNAL OF VIROLOGY

Cathepsin L Functionally Cleaves the Severe Acute Respiratory Syndrome Coronavirus Class I Fusion Protein Upstream of Rather than Adjacent to the Fusion Peptide

(2008) B. J. Bosch et al.   JOURNAL OF VIROLOGY

The diet-derived sulforaphane inhibits matrix metalloproteinase-9-activated human brain microvascular endothelial cell migration and tubulogenesis

(2008) Borhane Annabi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Flavan-3-ols: Nature, occurrence and biological activity

(2007) Patricia M. Aron et al.   MOLECULAR NUTRITION & FOOD RESEARCH