Journal
IMMUNOLOGICAL REVIEWS
Volume 280, Issue 1, Pages 41-56Publisher
WILEY
DOI: 10.1111/imr.12577
Keywords
alarmin; damage-associated molecular pattern; dendritic cells; immune response; tumor immunity
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Funding
- Intramural Research Program of NIH
- Frederick National Lab
- Center for Cancer Research, Cancer and Inflammation Program
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More than a decade has passed since the conceptualization of the alarmin hypothesis. The alarmin family has been expanding in terms of both number and the concept. It has recently become clear that alarmins play important roles as initiators and participants in a diverse range of physiological and pathophysiological processes such as host defense, regulation of gene expression, cellular homeostasis, wound healing, inflammation, allergy, autoimmunity, and oncogenesis. Here, we provide a general view on the participation of alarmins in the induction of innate and adaptive immune responses, as well as their contribution to tumor immunity.
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