An overview of the non-canonical inflammasome

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

(2020) Kun Wang et al.   CELL

Caspase-11 promotes allergic airway inflammation

(2020) Zbigniew Zasłona et al.   Nature Communications

HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1α-dependent acyloxyacyl hydrolase expression

(2020) Jiali Liu et al.   CELL DEATH AND DIFFERENTIATION

Toward targeting inflammasomes: insights into their regulation and activation

(2020) Shelbi Christgen et al.   CELL RESEARCH

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

(2020) Jun Jacob Hu et al.   NATURE IMMUNOLOGY

Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming

(2020) Margaret M. McDaniel et al.   Cell Reports

Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions

(2020) Miriam Kutsch et al.   EMBO JOURNAL

Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11

(2020) Betsaida Bibo-Verdugo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-11–mediated enteric neuronal pyroptosis underlies Western diet–induced colonic dysmotility

(2020) Lan Ye et al.   JOURNAL OF CLINICAL INVESTIGATION

Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome

(2020) Sampsa Matikainen et al.   JOURNAL OF IMMUNOLOGY

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

(2020) José Carlos Santos et al.   Nature Communications

Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death

(2020) Daniel Fisch et al.   Cell Reports

Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP3 Inflammasome

(2019) Renan V.H. de Carvalho et al.   Cell Reports

Inflammasome activation: a monocyte lineage privilege

(2019) Pierre Guermonprez et al.   NATURE IMMUNOLOGY

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model

(2019) Ziv Erlich et al.   NATURE IMMUNOLOGY

Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly

(2019) Kaiwen W Chen et al.   EMBO JOURNAL

IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype

(2019) Kimberley A. Wiggins et al.   AGING CELL

Innate immunity to intracellular LPS

(2019) Vijay A. K. Rathinam et al.   NATURE IMMUNOLOGY

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis

(2019) Ruochan Chen et al.   Science Advances

A genome‐wide screen identifies IRF2 as a key regulator of caspase‐4 in human cells

(2019) Sacha Benaoudia et al.   EMBO REPORTS

Caspases in Cell Death, Inflammation, and Disease

(2019) Nina Van Opdenbosch et al.   IMMUNITY

Caspase-11 Mediates Pyroptosis of Tubular Epithelial Cells and Septic Acute Kidney Injury

(2019) Zhiming Ye et al.   KIDNEY & BLOOD PRESSURE RESEARCH

The NLRP2 inflammasome in dorsal root ganglion as a novel molecular platform that produces inflammatory pain hypersensitivity

(2019) Yutaka Matsuoka et al.   PAIN

Pannexin‐1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation

(2019) Kaiwen W. Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Glutathione peroxidase 8 negatively regulates caspase‐4/11 to protect against colitis

(2019) Jye‐Lin Hsu et al.   EMBO Molecular Medicine

Functional crosstalk between non‐canonical caspase‐11 and canonical NLRP3 inflammasomes during infection‐mediated inflammation

(2019) Young‐Su Yi   IMMUNOLOGY

Ethyl pyruvate confers protection against endotoxemia and sepsis by inhibiting caspase-11-dependent cell pyroptosis

(2019) Xianhui Qiu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation

(2019) Kyle Caution et al.   Frontiers in Immunology

T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity

(2019) Aakanksha Jain et al.   NATURE IMMUNOLOGY

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

(2018) Rui Kang et al.   Cell Host & Microbe

LPS targets host guanylate‐binding proteins to the bacterial outer membrane for non‐canonical inflammasome activation

(2018) José Carlos Santos et al.   EMBO JOURNAL

The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice

(2018) Rosalie Heilig et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Membrane vesicles from Pseudomonas aeruginosa activate the non-canonical inflammasome through caspase-5 in human monocytes

(2018) Natalie J Bitto et al.   IMMUNOLOGY AND CELL BIOLOGY

Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1

(2018) Monica L. Gonzalez Ramirez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

COPs and POPs Patrol Inflammasome Activation

(2018) Mohanalaxmi Indramohan et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity

(2018) Sujun Li et al.   MOLECULAR MEDICINE

High-mobility group box 1 protein (HMGB1) operates as an alarmin outside as well as inside cells

(2018) Ulf Andersson et al.   SEMINARS IN IMMUNOLOGY

The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages

(2018) Lan H. Chu et al.   Nature Communications

Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11

(2018) Brice Lagrange et al.   Nature Communications

CASP4/caspase-11 promotes autophagosome formation in response to bacterial infection

(2018) Kathrin Krause et al.   Autophagy

Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation

(2018) Bettina L. Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish

(2018) Dahai Yang et al.   Nature Communications

Dysregulated hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensing

(2018) Shouwen Chen et al.   PLoS Pathogens

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis

(2018) Meihong Deng et al.   IMMUNITY

TRIF signaling is required for caspase-11-dependent immune responses and lethality in sepsis

(2018) Yiting Tang et al.   MOLECULAR MEDICINE

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

(2018) Sebastian Rühl et al.   SCIENCE

Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome

(2018) Jaye M. Platnich et al.   Cell Reports

A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death

(2018) Shigetoshi Yokoyama et al.   eLife

Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer

(2017) Je-Kyung Ryu et al.   IMMUNITY

By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation

(2017) Ivan Zanoni et al.   IMMUNITY

Caspase-11 non-canonical inflammasome: a critical sensor of intracellular lipopolysaccharide in macrophage-mediated inflammatory responses

(2017) Young-Su Yi   IMMUNOLOGY

High-affinity caspase-4 binding to LPS presented as high molecular mass aggregates or in outer membrane vesicles

(2017) Mark A Wacker et al.   Innate Immunity

Caspase-11 deficiency impairs neutrophil recruitment and bacterial clearance in the early stage of pulmonary Klebsiella pneumoniae infection

(2017) Jian Wang et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

(2017) Kwong Tai Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipopolysaccharide Potentiates Insulin-Driven Hypoglycemic Shock

(2017) Jon A. Hagar et al.   JOURNAL OF IMMUNOLOGY

Stearoyl Lysophosphatidylcholine Inhibits Endotoxin-Induced Caspase-11 Activation

(2017) Wenbo Li et al.   SHOCK

Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation

(2017) Yury I. Miller et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins

(2017) Ryan Finethy et al.   mBio

AIM2 Engages Active but Unprocessed Caspase-1 to Induce Noncanonical Activation of the NLRP3 Inflammasome

(2017) Larissa D. Cunha et al.   Cell Reports

Outer Membrane Vesicles Prime and Activate Macrophage Inflammasomes and Cytokine Secretion In Vitro and In Vivo

(2017) Jessica D. Cecil et al.   Frontiers in Immunology

Differential roles of caspase-1 and caspase-11 in infection and inflammation

(2017) Si Ming Man et al.   Scientific Reports

Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

(2016) Sivapriya Kailasan Vanaja et al.   CELL

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

(2016) Si Ming Man et al.   CELL

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Complement pathway amplifies caspase-11–dependent cell death and endotoxin-induced sepsis severity

(2016) Brooke A. Napier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides

(2016) Hana M. Russo et al.   JOURNAL OF IMMUNOLOGY

Ethyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuries

(2016) Runkuan Yang et al.   Journal of Inflammation-London

Oxidized phosphatidylcholine induces the activation of NLRP3 inflammasome in macrophages

(2016) Sang Hyeon Yeon et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells

(2016) M A Pallett et al.   Mucosal Immunology

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Interferon-induced guanylate-binding proteins in inflammasome activation and host defense

(2016) Bae-Hoon Kim et al.   NATURE IMMUNOLOGY

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

Caspase-11 attenuates gastrointestinal inflammation and experimental colitis pathogenesis

(2015) Tere M. Williams et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium

(2015) Youssef Aachoui et al.   Cell Host & Microbe

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+efflux

(2015) Sebastian Rühl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells

(2015) Jonathan L. Schmid-Burgk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

(2015) Dahai Yang et al.   IMMUNITY

Inhibiting the inflammasome: one domain at a time

(2015) Andrea Dorfleutner et al.   IMMUNOLOGICAL REVIEWS

Induction of Caspase-11 by Aspartyl Proteinases of Candida albicans and Implication in Promoting Inflammatory Response

(2015) Elena Gabrielli et al.   INFECTION AND IMMUNITY

Prostaglandin E2Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages

(2015) Milena Sokolowska et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens

(2015) Cierra N. Casson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-11 Plays an Essential Role in Methamphetamine-Induced Dopaminergic Neuron Apoptosis

(2015) Weiye Huang et al.   TOXICOLOGICAL SCIENCES

Single-cell imaging of inflammatory caspase dimerization reveals differential recruitment to inflammasomes

(2015) M G Sanders et al.   Cell Death & Disease

Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes

(2015) Elena Viganò et al.   Nature Communications

Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance

(2015) Kyle Caution et al.   Scientific Reports

An updated view on the structure and function of PYRIN domains

(2014) Lan Hoang Chu et al.   APOPTOSIS

Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis

(2014) J Xu et al.   CELL DEATH AND DIFFERENTIATION

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

(2014) Leigh A. Knodler et al.   Cell Host & Microbe

High Mobility Group Box 1 Protein Binding to Lipopolysaccharide Facilitates Transfer of Lipopolysaccharide to CD14 and Enhances Lipopolysaccharide-Mediated TNF-  Production in Human Monocytes

(2014) J. H. Youn et al.   JOURNAL OF IMMUNOLOGY

Protective Role for Caspase-11 during Acute Experimental Murine Colitis

(2014) Katarzyna Oficjalska et al.   JOURNAL OF IMMUNOLOGY

A Critical Role for Human Caspase-4 in Endotoxin Sensitivity

(2014) Y. Kajiwara et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis

(2014) D Demon et al.   Mucosal Immunology

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

(2014) Etienne Meunier et al.   NATURE

Role of the Inflammasome-Caspase1/11-IL-1/18 Axis in Cigarette Smoke Driven Airway Inflammation: An Insight into the Pathogenesis of COPD

(2014) Suffwan Eltom et al.   PLoS One

Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS

(2014) D. M. Pilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-11 Controls Interleukin-1β Release through Degradation of TRPC1

(2014) Bénédicte F. Py et al.   Cell Reports

The Shigella OspC3 Effector Inhibits Caspase-4, Antagonizes Inflammatory Cell Death, and Promotes Epithelial Infection

(2013) Taira Kobayashi et al.   Cell Host & Microbe

Human astrocytes express a novel NLRP2 inflammasome

(2013) Julia Minkiewicz et al.   GLIA

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

The E. coli Effector Protein NleF Is a Caspase Inhibitor

(2013) Sonja Blasche et al.   PLoS One

Intracellular Shigella remodels its LPS to dampen the innate immune recognition and evade inflammasome activation

(2013) I. Paciello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Caspase-11 Protects Against Bacteria That Escape the Vacuole

(2013) Y. Aachoui et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol

(2013) Cierra N. Casson et al.   PLoS Pathogens

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

IFN-Inducible GTPases in Host Cell Defense

(2012) Bae-Hoon Kim et al.   Cell Host & Microbe

Secreted aspartic proteases ofCandida albicansactivate the NLRP3 inflammasome

(2012) Donatella Pietrella et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization

(2012) Anwari Akhter et al.   IMMUNITY

The NLRP12 Inflammasome Recognizes Yersinia pestis

(2012) Gregory I. Vladimer et al.   IMMUNITY

Caspase-4 Is Required for Activation of Inflammasomes

(2012) G. Sollberger et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

(2012) Petr Broz et al.   NATURE

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

Identification of lipopolysaccharide-binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model

(2011) Ju Ho Youn et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation

(2011) Y. Qu et al.   JOURNAL OF IMMUNOLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

HMGB1 release by inflammasomes

(2011) Lieselotte Vande Walle et al.   Virulence

Oxidized Phospholipids Are More Potent Antagonists of Lipopolysaccharide than Inducers of Inflammation

(2010) O. V. Oskolkova et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NLRC5-Dependent Activation of the Inflammasome

(2010) B. K. Davis et al.   JOURNAL OF IMMUNOLOGY

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

(2010) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Oxidized Phospholipid Inhibition of LPS-Signaling

(2009) Clett Erridge   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Caspases: evolutionary aspects of their functions in vertebrates

(2009) K. Sakamaki et al.   JOURNAL OF FISH BIOLOGY

NLRP3 (NALP3, Cryopyrin) Facilitates In Vivo Caspase-1 Activation, Necrosis, and HMGB1 Release via Inflammasome-Dependent and -Independent Pathways

(2009) S. B. Willingham et al.   JOURNAL OF IMMUNOLOGY

The Evolutionarily Dynamic IFN-Inducible GTPase Proteins Play Conserved Immune Functions in Vertebrates and Cephalochordates

(2009) G. Li et al.   MOLECULAR BIOLOGY AND EVOLUTION