Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation

To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps

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Untangling “NETosis” from NETs

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An emerging role of neutrophils and NETosis in chronic inflammation and fibrosis in systemic lupus erythematosus (SLE) and ANCA-associated vasculitides (AAV): Implications for the pathogenesis and treatment

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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

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Gasdermin D Flashes an Exit Signal for IL-1

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The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Caspases-1 and caspase-11 mediate pyroptosis, inflammation, and control of Brucella joint infection

(2018) Carolyn A. Lacey et al.   INFECTION AND IMMUNITY

The expression of Mirc1/Mir17–92 cluster in sputum samples correlates with pulmonary exacerbations in cystic fibrosis patients

(2018) Kathrin Krause et al.   Journal of Cystic Fibrosis

PKD regulates actin polymerization, neutrophil deformability, and transendothelial migration in response to fMLP and trauma

(2018) Christoph Wille et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Necroptosis and neutrophil-associated disorders

(2018) Xiaoliang Wang et al.   Cell Death & Disease

Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11

(2018) Brice Lagrange et al.   Nature Communications

CASP4/caspase-11 promotes autophagosome formation in response to bacterial infection

(2018) Kathrin Krause et al.   Autophagy

Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation

(2018) Bettina L. Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses

(2018) Frank H. Robledo-Avila et al.   JOURNAL OF IMMUNOLOGY

The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection

(2018) Hideki Hara et al.   CELL

Caspase-11 non-canonical inflammasome: a critical sensor of intracellular lipopolysaccharide in macrophage-mediated inflammatory responses

(2017) Young-Su Yi   IMMUNOLOGY

ROS and glutathionylation balance cytoskeletal dynamics in neutrophil extracellular trap formation

(2017) Darko Stojkov et al.   JOURNAL OF CELL BIOLOGY

OUP accepted manuscript

(2017)   RHEUMATOLOGY

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Neutrophil Extracellular Traps and Microcrystals

(2017) Balázs Rada   Journal of Immunology Research

Gout: An old disease in new perspective – A review

(2017) Gaafar Ragab et al.   Journal of Advanced Research

Differential roles of caspase-1 and caspase-11 in infection and inflammation

(2017) Si Ming Man et al.   Scientific Reports

Elevated Mirc1/Mir17-92 cluster expression negatively regulates autophagy and CFTR (cystic fibrosis transmembrane conductance regulator) function in CF macrophages

(2016) Mia F. Tazi et al.   Autophagy

Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

(2016) Sivapriya Kailasan Vanaja et al.   CELL

Macrophage-derived IL-1β enhances monosodium urate crystal-triggered NET formation

(2016) Payel Sil et al.   INFLAMMATION RESEARCH

Complement pathway amplifies caspase-11–dependent cell death and endotoxin-induced sepsis severity

(2016) Brooke A. Napier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New tools to tackle inflammatory arthritis

(2016) Charles A. Dinarello et al.   Nature Reviews Rheumatology

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

Rac signal adaptation controls neutrophil mobilization from the bone marrow

(2016) C. C. Campa et al.   Science Signaling

Neutrophil extracellular traps in health and disease

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Rac signal adaptation controls neutrophil mobilization from the bone marrow

(2016) C. C. Campa et al.   Science Signaling

The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages

(2016) Arwa Abu Khweek et al.   PLoS One

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

A chimeric human–mouse model of Sjögren's syndrome

(2015) Nicholas A. Young et al.   CLINICAL IMMUNOLOGY

PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling

(2015) Jyaysi Desai et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

(2015) Paul J. Baker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NET formation can occur independently of RIPK3 and MLKL signaling

(2015) Poorya Amini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pyroptosis: Caspase-11 Unlocks the Gates of Death

(2015) Aude de Gassart et al.   IMMUNITY

Caspase-11: arming the guards against bacterial infection

(2015) Irma Stowe et al.   IMMUNOLOGICAL REVIEWS

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

How neutrophil extracellular traps orchestrate the local immune response in gout

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Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance

(2015) Kyle Caution et al.   Scientific Reports

Caspase-11 Controls Interleukin-1β Release through Degradation of TRPC1

(2014) Bénédicte F. Py et al.   Cell Reports

Gout

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Clinical next-generation sequencing successfully applied to fine-needle aspirations of pulmonary and pancreatic neoplasms

(2013) Geneva Young et al.   CANCER CYTOPATHOLOGY

Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton

(2013) Yuan He et al.   MOLECULAR BIOLOGY OF THE CELL

Neutrophil extracellular traps as a new paradigm in innate immunity: friend or foe?

(2013) Paul R. Cooper et al.   PERIODONTOLOGY 2000

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization

(2012) Anwari Akhter et al.   IMMUNITY

Depletion of the Ubiquitin-binding Adaptor Molecule SQSTM1/p62 from Macrophages HarboringcftrΔF508 Mutation Improves the Delivery ofBurkholderia cenocepaciato the Autophagic Machinery

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Autophagy stimulation by rapamycin suppresses lung inflammation and infection byBurkholderia cenocepaciain a model of cystic fibrosis

(2011) Basant A. Abdulrahman et al.   Autophagy

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

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Non-canonical inflammasome activation targets caspase-11

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Neutrophil Extracellular Trap Formation Is Associated with IL-1β and Autophagy-Related Signaling in Gout

(2011) Ioannis Mitroulis et al.   PLoS One

Asc-Dependent and Independent Mechanisms Contribute to Restriction of Legionella Pneumophila Infection in Murine Macrophages

(2011) Dalia H. A. Abdelaziz et al.   Frontiers in Microbiology

How interleukin-1β induces gouty arthritis

(2010) Charles A. Dinarello   ARTHRITIS AND RHEUMATISM

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

Differences in MSU-induced Superoxide Responses by Neutrophils from Gout Subjects Compared to Healthy Controls and a Role for Environmental Inflammatory Cytokines and Hyperuricemia in Neutrophil Function and Survival

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A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of inflammation in gout

(2010) Nathalie Busso et al.   ARTHRITIS RESEARCH & THERAPY

Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis

(2009) R Torres et al.   ANNALS OF THE RHEUMATIC DISEASES

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

(2009) Hideyuki Yanai et al.   NATURE

Random versus directionally persistent cell migration

(2009) Ryan J. Petrie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection

(2009) Anwari Akhter et al.   PLoS Pathogens

Moving towards a Better Understanding of Chemotaxis

(2008) Len Stephens et al.   CURRENT BIOLOGY