Outer Membrane Vesicles Prime and Activate Macrophage Inflammasomes and Cytokine Secretion In Vitro and In Vivo

Signal transduction analysis of the NLRP3-inflammasome pathway after cellular damage and its paracrine regulation

(2017) Denise Veltman et al.   JOURNAL OF THEORETICAL BIOLOGY

Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

(2016) Sivapriya Kailasan Vanaja et al.   CELL

Immune response of macrophages induced by Porphyromonas gingivalis requires HmuY protein

(2016) Anna Gmiterek et al.   IMMUNOBIOLOGY

Porphyromonas gingivalis Outer Membrane Vesicles Induce Selective Tumor Necrosis Factor Tolerance in a Toll-Like Receptor 4- and mTOR-Dependent Manner

(2016) Tobias Waller et al.   INFECTION AND IMMUNITY

Porphyromonas gulae Has Virulence and Immunological Characteristics Similar to Those of the Human Periodontal Pathogen Porphyromonas gingivalis

(2016) Jason C. Lenzo et al.   INFECTION AND IMMUNITY

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Differential Responses of Pattern Recognition Receptors to Outer Membrane Vesicles of Three Periodontal Pathogens

(2016) Jessica D. Cecil et al.   PLoS One

Unprimed, M1 and M2 Macrophages Differentially Interact with Porphyromonas gingivalis

(2016) Roselind S. Lam et al.   PLoS One

Monocyte and Macrophage Plasticity in Tissue Repair and Regeneration

(2015) Amitava Das et al.   AMERICAN JOURNAL OF PATHOLOGY

Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling

(2015) Christina Antonopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Outer membrane vesicles ofTannerella forsythia: biogenesis, composition, and virulence

(2015) V. Friedrich et al.   Molecular Oral Microbiology

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

The immune potential and immunopathology of cytokine-producing B cell subsets: A comprehensive review

(2014) Yan Bao et al.   JOURNAL OF AUTOIMMUNITY

Macrophage Polarization in Bacterial Infections

(2014) M. Benoit et al.   JOURNAL OF IMMUNOLOGY

Macrophage Depletion AbatesPorphyromonas gingivalis–Induced Alveolar Bone Resorption in Mice

(2014) Roselind S. Lam et al.   JOURNAL OF IMMUNOLOGY

A Novel Flow Cytometric Method To Assess Inflammasome Formation

(2014) David P. Sester et al.   JOURNAL OF IMMUNOLOGY

Porphyromonas gingivalis Outer Membrane Vesicles Exclusively Contain Outer Membrane and Periplasmic Proteins and Carry a Cargo Enriched with Virulence Factors

(2014) Paul D. Veith et al.   JOURNAL OF PROTEOME RESEARCH

The inflammophilic character of the periodontitis-associated microbiota

(2014) G. Hajishengallis   Molecular Oral Microbiology

Porphyromonas gingivalis and Treponema denticola Exhibit Metabolic Symbioses

(2014) Kheng H. Tan et al.   PLoS Pathogens

Interleukin-10 Inhibits Bone Resorption: A Potential Therapeutic Strategy in Periodontitis and Other Bone Loss Diseases

(2014) Qian Zhang et al.   Biomed Research International

Structure and Immunogenicity of the Rough-Type Lipopolysaccharide from the Periodontal Pathogen Tannerella forsythia

(2013) Gerald Posch et al.   Clinical and Vaccine Immunology

Activation of NLRP3 and AIM2 Inflammasomes by Porphyromonas gingivalis Infection

(2013) Eunjoo Park et al.   INFECTION AND IMMUNITY

Tetra- and Penta-Acylated Lipid A Structures of Porphyromonas gingivalis LPS Differentially Activate TLR4-Mediated NF-κB Signal Transduction Cascade and Immuno-Inflammatory Response in Human Gingival Fibroblasts

(2013) Thanuja D. K. Herath et al.   PLoS One

Porphyromonas gingivalis and Treponema denticola Synergistic Polymicrobial Biofilm Development

(2013) Ying Zhu et al.   PLoS One

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Subversion of inflammasome activation and pyroptosis by pathogenic bacteria

(2013) Larissa D. Cunha et al.   Frontiers in Cellular and Infection Microbiology

Virulence Mechanism of Bacteria in Mixed Infection: Attenuation of Cytokine Levels and Evasion of Polymorphonuclear Leukocyte Phagocytosis

(2012) David Polak et al.   JOURNAL OF PERIODONTOLOGY

Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology

(2012) G. Hajishengallis et al.   Molecular Oral Microbiology

Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement

(2011) George Hajishengallis et al.   Cell Host & Microbe

Elicitation of Epithelial Cell-Derived Immune Effectors by Outer Membrane Vesicles of Nontypeable Haemophilus influenzae

(2011) Samantha W. Sharpe et al.   INFECTION AND IMMUNITY

Synergistic virulence of Porphyromonas gingivalis and Treponema denticola in a murine periodontitis model

(2011) R.K-H. Orth et al.   Molecular Oral Microbiology

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Outer Membrane Vesicles of Porphyromonas gingivalis Elicit a Mucosal Immune Response

(2011) Ryoma Nakao et al.   PLoS One

Hemagglutinin/Adhesin domains ofPorphyromonas gingivalisplay key roles in coaggregation withTreponema denticola

(2010) Rieko Ito et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Selective Sorting of Cargo Proteins into Bacterial Membrane Vesicles

(2010) M. Florencia Haurat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Virulence and Immunomodulatory Roles of Bacterial Outer Membrane Vesicles

(2010) T. N. Ellis et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

NO production in RAW264 cells stimulated with Porphyromonas gingivalis extracellular vesicles

(2010) R Imayoshi et al.   ORAL DISEASES

Inhibition of Apoptosis in Periodontitis

(2009) H. Lucas et al.   JOURNAL OF DENTAL RESEARCH

Progression of chronic periodontitis can be predicted by the levels ofPorphyromonas gingivalisandTreponema denticolain subgingival plaque

(2009) S. J. Byrne et al.   Oral microbiology and immunology

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Porphyromonas gingivalis RgpA-Kgp Proteinase-Adhesin Complexes Penetrate Gingival Tissue and Induce Proinflammatory Cytokines or Apoptosis in a Concentration-Dependent Manner

(2008) N. M. O'Brien-Simpson et al.   INFECTION AND IMMUNITY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY